Global HEOR Evidence Synthesis Senior Manager

Amgen; Hyderabad; On-site; INR 4,000,000 - 6,500,000; Full time

Job summary

Amgen Hyderabad seeks an experienced Global HEOR Evidence Synthesis Manager to lead complex evidence synthesis and health economic analyses that inform HTA decisions. You will collaborate with HEOR product leads to align analyses with product strategy, mentor team members, and drive methodological innovation in Bayesian statistics and AI-enabled approaches.

You will design analyses such as meta-analyses, MAICs, STCs, and cost-effectiveness models, while overseeing data quality and adapt to

Qualifications

• Bachelor’s/Master’s/Doctoral in quantitative field (statistics, biostatistics, mathematics, OR/health economics).
• +12 years for Master’s degree or +14 years for Bachelor’s degree in evidence synthesis/stats role.
• Experience in HTA/cost-effectiveness/cost-utility and budget impact analyses; familiarity with health economics modeling.

Responsibilities

• Provide methodological leadership in advanced evidence synthesis (Pairwise ITCs, NMA, MAIC/STC).
• Design and lead health economic models across product life cycle (cost-effectiveness, budget impact).
• Ensure quality standards across analyses and document statistical/economic methods.

Skills

Evidence synthesis

Statistical analyses

Survival analysis

Meta-analysis

Bayesian statistics

AI techniques

Project management

Communication

Education

Bachelor’s/Master’s/Doctoral in quantitative field

Tools

Excel

WinBUGS/OpenBUGS

JAGS

R

Python

Job description

Career Category

Operations

Job Description

Department: Global Health Economics & Outcomes Research (HEOR)

Job Family: Evidence Synthesis

Job Type: Full-Time

Location: Hyderabad, India

Reports To: Global Value & Access AIN Head

Position Summary

The Global HEOR Evidence Synthesis Manager plays a critical role in supporting Amgen’s global market access and health economics strategy through contributing statistical capabilities and methodological leadership for evidence synthesis methodologies (meta-analyses & ITCs). This role will partner closely with Global HEOR Product Leads to ensure strong alignment with product strategy. The Evidence Synthesis Senior Manager will lead different evidence pooling analyses ranging from meta-analyses, network meta-analyses to population-adjusted indirect treatment comparisons (MAICs and STCs) and health-economic analyses facilitating HTA and payer decision-making.

Educational Qualifications

A Bachelor’s, Master’s or Doctoral-level degree in applied statistics , biostatistics, mathematics, operations research, engineering, health economics, pharmacy, and related quantitative fields

Required experience/ knowledge

• Years of relevant experience in evidence synthesis and statistical analyses in the pharmaceutical, biotech or consulting setting: +12 years for Master’s degree and +14 years for Bachelor’s degree.
• Expertise in research design and statistical methods, including estimating survival, pooled treatment effects and other methods to estimate treatment effect
• Experience in leading health economic analyses such as cost-effectiveness/cost-utility (e.g., markov, partitioned survival model), cost minimization, budget impact, and other techniques, as appropriate
• Proficiency with modeling and statistical tools such as Excel, WinBugs, OpenBugs, JAGS, R or Python.
• Experience in AI/ ML techniques and Bayesian statistics is a plus.

Key Responsibilities

• Design and provide methodological leadership in advanced evidence synthesis and statistical analyses such as Pairwise Meta-Analysis, Surrogate outcome assessment, Survival analysis, External Control Arm (ECA) analysis, Indirect treatment comparison (ITCs), Network Meta-Analysis, Match adjusted indirect treatment analysis(MAIC), Simulated treatment comparison (STC) and Meta-regression
• Design and lead health economic models for products at all stages of development and launch, using cost-effectiveness/cost-utility (e.g., markov, partitioned survival model), cost minimization, budget impact, and other techniques, as appropriate.
• Ensure quality standards are adhered to in all analyses and new methodologies and techniques are adequately assessed and implemented.
• Plan and conduct statistical analyses of clinical trials, RWE and other relevant data sources and develop supporting technical documentation for statistical analyses and economic models.
• Work closely with HEOR Product Leads to ensure analyses and models follow product strategy.
• Monitor and integrate evolving HTA guidelines, payer requirements, and methodological advancements.
• To foster thought leadership opportunities
• To proactively mentor and develop members of the team

Skills & Competencies

• Excellent English oral and written communication, with ability to tailor content to different stakeholders.
• Strong quantitative and analytical skills with attention to detail.
• Strong project management and time-management abilities.
• Innovative use of artificial intelligence to boost efficiency.

Organizational Behaviors

• Effective cross-functional collaboration and interpersonal skills.
• Proactive, independent, and detail-oriented approach to problem-solving.
• Comfortable working in a global team across time zones and cultures.

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