Data Engineer - Pharma R&D

F. Hoffmann-La Roche AG; Hyderabad; On-site; INR 1,500,000 - 2,100,000; Full time

Job summary

Roche in Hyderabad is hiring a Data Engineer – Clinical Study Design to build data pipelines and models powering Study Designer, a digital product for designing studies. You will design data models in Aurora and GraphDB, create NLP/embedding pipelines for RAG workflows, and deliver APIs with FastAPI to feed a web frontend, while ensuring regulatory traceability.

Ideal candidates bring 5–8 years of experience with production-grade data platforms, biomedical graphs, and Spark/Databricks, and hold

Qualifications

• Bachelor's degree in Computer Science, Data Engineering, or related discipline.
• 5-8 years of experience building production-grade data platforms and pipelines.
• Experience with biomedical knowledge graphs (e.g., linking drugs -> targets -> diseases -> trials)
• Prior work with PubMed/MEDLINE data, ClinicalTrials.gov API, or EMA/CTIS data
• Apache Spark or Databricks for batch processing of large documents.

Responsibilities

• Build ingestion pipelines for clinical trial protocols, ICF documents, SmPCs, CSRs, and published articles (PubMed, CTIS, ClinicalTrials.gov) - handling PDF parsing, text extraction, and structured data normalization
• Design and implement data models in Amazon Aurora (relational) and GraphDB to represent trial design entities: endpoints, eligibility criteria, study arms, interventions, therapeutic areas, and their relationships
• Develop embedding and vectorization pipelines to prepare extracted clinical text for RAG-based retrieval in LangGraph agentic workflows - chunking strategies, metadata enrichment, and vector store population
• Build and maintain ETL/ELT workflows that transform unstructured clinical content into queryable, linked data across both relational and graph stores
• Implement data quality validation specific to clinical data - protocol section classification accuracy, entity extraction completeness, cross-reference integrity (NCT IDs, EudraCT numbers, MeSH terms)
• Build data serving APIs (Python/FastAPI) that expose curated datasets to the Angular frontend and LangGraph agent layer
• Set up data lineage tracking and audit trails to support regulatory traceability of AI-generated trial design recommendations

Skills

Python

SQL (PostgreSQL/Aurora)

Graph Databases

NLP / Text processing

AWS (Aurora, S3, Lambda)

FastAPI

ETL/ELT pipelines

Spark/Databricks

Education

Bachelor’s degree in Computer Science, Data Engineering, or related discipline

Tools

Neptune / Neo4j

SPARQL / Cypher

OpenSearch / vector stores

pgvector

Terraform / CDK

Job description

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters. The Position Job Description: The Data Engineer – Clinical Study Design sits at the intersection of data architecture, clinical science, and technology delivery, helping build the data foundation behind Study Designer, a digital product transforming how studies are designed. This role combines strong data engineering skills, an understanding of clinical study data and workflows, and technical curiosity to translate complex clinical data structures into reliable, scalable pipelines and models that power the platform's insights. The ideal candidate is curious, collaborative, AI-minded, and passionate about using data to enable smarter, faster, and more effective clinical study design.

Key Responsibilities

• Build ingestion pipelines for clinical trial protocols, ICF documents, SmPCs, CSRs, and published articles (PubMed, CTIS, ClinicalTrials.gov) - handling PDF parsing, text extraction, and structured data normalization
• Design and implement data models in Amazon Aurora (relational) and GraphDB (knowledge graph) to represent trial design entities: endpoints, eligibility criteria, study arms, interventions, therapeutic areas, and their relationships
• Develop embedding and vectorization pipelines to prepare extracted clinical text for RAG-based retrieval in LangGraph agentic workflows - chunking strategies, metadata enrichment, and vector store population
• Build and maintain ETL/ELT workflows that transform unstructured clinical content into queryable, linked data across both relational and graph stores
• Implement data quality validation specific to clinical data - protocol section classification accuracy, entity extraction completeness, cross-reference integrity (NCT IDs, EudraCT numbers, MeSH terms)
• Build data serving APIs (Python/FastAPI) that expose curated datasets to the Angular frontend and LangGraph agent layer
• Set up data lineage tracking and audit trails to support regulatory traceability of AI-generated trial design recommendations

Preferred Qualifications

• Education: Bachelor's degree in Computer Science, Data Engineering, or a related discipline.
• 5-8 years of experience building production grade data platforms and pipelines.
• Experience with biomedical knowledge graphs (e.g., linking drugs -> targets -> diseases -> trials)
• Prior work with PubMed/MEDLINE data, ClinicalTrials.gov API, or EMA/CTIS data
• Apache Spark or Databricks for batch processing of large document

Required Skills

• Python — Primary language; experience with PDF/document parsing libraries (PyMuPDF, pdfplumber, unstructured.io, or similar)
• SQL — Advanced PostgreSQL-compatible SQL (Aurora); schema design, migrations, query optimization, indexing strategies for clinical data volumes
• Graph Databases — Hands-on with Neptune, Neo4j, or similar; SPARQL or Cypher query language; ontology/knowledge graph modeling for biomedical entities
• AWS — Aurora (PostgreSQL), S3, Lambda, Step Functions, SQS/SNS, IAM; infrastructure for data pipeline orchestration
• NLP / Document Processing — Text extraction from PDFs, section classification, named entity recognition for clinical/biomedical text; familiarity with embedding models and vector stores (OpenSearch, pgvector, or Pinecone)
• FastAPI — Building data serving endpoints; async patterns; integration with the application backend
• AI/ML Data Infrastructure — Preparing data for LangChain/LangGraph consumption; RAG pipeline design (chunking, retrieval, reranking); prompt-data integration patterns
• Pipeline Orchestration — Experience with workflow orchestration tools (Airflow, Prefect, Step Functions, or Temporal); designing DAGs for multi-stage data pipelines with dependency management, retry logic, and monitoring
• CI/CD & IaC — Terraform or CDK, Docker, Git; automated pipeline testing and deployment on AWS

Shift

Shift: CET time zone #Hyderabad2026

Who we are

A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products.

We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact. Let’s build a healthier future, together.

Roche is an Equal Opportunity Employer. We believe it’s urgent to deliver medical solutions right now – even as we develop innovations for the future. We are passionate about transforming patients’ lives. We are courageous in both decision and action. And we believe that good business means a better world. That is why we come to work each day. We commit ourselves to scientific rigor, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow. We are proud of who we are, what we do, and how we do it. We are many, working as one across functions, across companies, and across the world. We are Roche.