BBRC - Associate Scientific Director - Downstream Processing and Manufacturability Assessment

Syngene International; Bengaluru; On-site; INR 3,000,000 - 6,000,000; Full time

Job summary

Syngene International in Bengaluru is seeking an Associate Scientific Director / Principal Scientist to establish and lead Downstream Processing and Manufacturability Assessment capabilities for early biotherapeutic discovery. You will oversee purification strategy, chromatography, endotoxin control, formulation, scale-up, technology transfer and documentation.

The role requires a PhD in a related field and 8+ years of biotech/biopharma purification experience, including 3+ years in people

Qualifications

• PhD in biochemistry, protein chemistry, biotechnology, biochemical engineering, or related discipline.
• 8+ years of protein purification or bioprocess development experience in biotech/biopharma.
• 3+ years leading scientists or matrixed teams.

Responsibilities

• Establish and lead purification-process development and manufacturability assessment platforms for antibodies, multispecifics, Fc-fusions, antibody fragments, recombinant antigens, and emerging biologic formats.
• Design fit-for-purpose purification strategies (1–200L scale) using capture, intermediate, and polishing technologies.
• Deliver research- and toxicology-grade material meeting identity, purity, aggregation, potency, endotoxin, sterility, stability, and formulation requirements.
• Scale purification processes, establish transfer packages, define in-process controls, troubleshoot, and support batch disposition.
• Lead, coach, recruit, and develop a high-performing team while strengthening collaboration, safety, scientific rigor, inclusion, innovation, and compliance.

Skills

Protein purification

Bioprocess development

Multi-step chromatography

Scale-up

Team leadership

Scientific communication

Developability assessment

Protein analytics

Education

PhD in biochemistry/biotechnology/biochemical engineering

Job description

Designation: Associate Scientific Director / Principal Scientist — Downstream Processing and Manufacturability Assessment

Department: Discovery Biotherapeutics / Discovery Technologies

Incorporated in 1993, Syngene International Ltd. is an innovation-focused global discovery, development and manufacturing organization providing integrated scientific services to the pharmaceutical, biotechnology, nutrition, animal health, consumer goods and specialty chemical industries around the world. Syngene’ s clientele includes world leaders such as Bristol-Myers Squibb, Baxter, Amgen, GSK, Merck KGaA and Herbalife. Its innovative culture is driven by the passion of its 4240- strong team of scientists who work with clients from around the world to solve their scientific problems, improve R&D productivity, speed up time to market and lower the cost of innovation.

Job Purpose:

• BBRC is seeking an accomplished purification and developability leader to establish and lead Downstream Processing and Manufacturability Assessment capabilities in support of early biotherapeutic discovery. The role will enable scalable purification workflows, high-quality research- and toxicology-grade proteins, and actionable manufacturability insight for candidate progression.
• The successful candidate will provide hands‑on technical leadership across purification strategy, multi‑step chromatography, endotoxin control, formulation, filtration, scale‑up, technology transfer, and documentation for diverse biologic modalities.

Key Responsibilities:

• Establish and lead purification‑process development and manufacturability assessment platforms for antibodies, multispecifics, Fc‑fusions, antibody fragments, recombinant antigens, and emerging biologic formats.
• Design fit‑for‑purpose purification strategies (1-200L scale) using capture, intermediate, and polishing technologies across chromatographic, membrane‑based, and related approaches.
• Deliver research- and toxicology‑grade material meeting expectations for identity, purity, aggregation, potency, endotoxin, sterility/bioburden, stability, formulation, and intended‑study use.
• Scale purification processes, establish transfer packages, define in‑process controls, troubleshoot process failures, and support batch disposition with clear scientific rationale.
• Lead, coach, recruit, and develop a high‑performing team while strengthening collaboration, safety, scientific rigor, inclusion, innovation, and compliance.

Educational Qualification:

Ph.D. in biochemistry, protein chemistry, biotechnology, biochemical engineering, bioengineering, or a related discipline.

Experience:

8+ years

Technical/functional Skills:

Required:

• 8+ years of relevant protein‑purification or bioprocess‑development experience in biotechnology or biopharma, including 3+ years leading scientists, technical teams, or matrixed workstreams.
• Deep expertise in multi‑step chromatography, recombinant‑protein purification, scale‑up, reproducibility, concentration, buffer exchange, formulation, sterile filtration, storage, and troubleshooting.
• Experience supporting research, preclinical, toxicology, or development‑scale protein material, with working knowledge of protein analytics and developability assessment.
• Excellent scientific judgment, communication, stakeholder‑influence, and people‑leadership skills.

Preferred:

Experience with complex biologic formats, tox‑batch/preclinical material requirements, GLP/GMP‑adjacent documentation, batch records, CoAs, deviations, technical transfer, high‑throughput resin screening, automation, continuous chromatography, membrane‑based purification, or demonstrated purification‑platform innovation.

Behavioral Skills:

Strong problem‑solving and data analysis skills, excellent written and verbal communication skills, good presentation skills, and the ability to handle multiple projects simultaneously and meet aggressive project timelines. Must demonstrate integrity and take accountability for their work

Equal Opportunity Employer:

It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodation for qualified individuals with disabilities.