Analytical Scientist

Cpl; Dublin; On-site; EUR 52,000 - 78,000; Full time

Job summary

Pfizer is seeking an Analytical Scientist at Grange Castle to contribute to analytical characterization of therapeutic glycoproteins, mRNA and vaccines. You will develop methods, support manufacturing and collaborate with process development, quality, and regulatory teams.

Ideal candidates hold a MSc in analytical chemistry or related field, with 3–5 years in pharma analytical roles and experience in HPLC/UPLC, MS, ELISA, and glycoprotein/vaccine analysis.

Qualifications

• B.Sc. / M.Sc. or higher in analytical biochemistry, chemistry, biotechnology or related.

Responsibilities

• Develop and apply analytical methods for proteins, vaccines and small molecules.
• Provide analytical support to process development and manufacturing
• Contribute to regulatory submissions and technical documentation
• Evaluate and qualify analytical technologies for development and QC labs

Skills

UPLC/HPLC

Mass spectrometry

Glycoproteins

Vaccine analytics

Data interpretation

Regulatory awareness

Team collaboration

Education

MSc in analytical chemistry

Biochemistry degree

Tools

FACS

ELISA

Capillary electrophoresis

HPLC/UPLC

Mass spectrometry

Job description

Analytical Scientist – Pfizer, Grange Castle

Working in a multidisciplinary analytical team you will contribute to the characterisation and analysis of therapeutic glycoproteins, mRNA and conjugate vaccines.

Your role will be to provide analytical characterisation, new method and technology development, and technical support to several functional groups including: Protein and Vaccine Process

Development and pilot scale manufacturing operations, Commercial manufacturing, and the Quality and Regulatory units.

This is what you can look forward to:

• Become expert in the application and development of analytical methods used for the characterisation and manufacturing support of therapeutic proteins, vaccines and small molecules.
• Participate in cross-functional teams in support of late-stage development and commercial products.
• Provide technical subject matter expert and investigative support to commercial manufacturing operations.
• Participate in the technical writing and review of analytical documentation, and regulatory submissions and responses.
• Evaluate, develop and qualify analytical technologies to support method improvements for use in analytical development and QC laboratories.
• Provide analytical support to process development team in bench and pilot scale production of proteins and vaccines, including sample analysis and interpretation of results, as required.

What you offer:

To be successful in this role you will require:

• B.Sc. / M.Sc. or higher qualification in analytical biochemistry, chemistry, biotechnology or a related discipline.
• 3-5 years’ experience in analytical role in pharmaceutical industry, experience with biological products and/or vaccines an advantage
• Technical capability in several major areas of analytical sciences such as: UPLC / HPLC (UV, FLR, CAD), MS, GC, spectrophotometry, bioassay, ELISA, FACS, wet chemistry techniques and capillary electrophoresis. Experience characterising glycoproteins, monoclonal antibodies and vaccines an advantage.
• Independent contributions as a scientist through one or more of the following:
• Demonstration of problem solving ability through independent contributions to analytical method development/qualification/validation programs.
• Lead role in analytical investigative support.
• Subject matter expertise in one or more analytical technologies.
• Ability to independently plan and perform work assignments, interpret and present data.
• Possession of technical problem-solving abilities and communication skills – accredited lean/six sigma/DMAIC competency is desirable.
• Capability of coordinating activities and delivering project goals working in a multi-disciplinary team environment.
• An understanding of industry specific standards/ regulations e.g. ICH, GMP, Environmental, Health and Safety etc.
• Demonstration of ability to interpret industry guidelines for execution of technology transfer and implementation of analytical method validations considered an advantage.
• Experience in authoring/contributing to analytical aspects of regulatory submissions and agency responses.