Clinical Research Associate II

Parexel; Hong Kong; On-site; HKD 600,000 - 900,000; Full time

Job summary

Parexel in Hong Kong is seeking a Site Start-Up Lead to manage end-to-end startup activities for assigned clinical sites. You will coordinate with investigators and regulatory bodies, ensuring timely feasibility assessments, approvals, and study initiation.

Role requires strong problem solving, stakeholder management, and experience in regulatory submissions. Occasional travel and collaboration with global teams are expected.

Qualifications

• Knowledge of ICH-GCP guidelines and clinical trial basics.
• Experience with site management and regulatory submissions is valued.
• Strong written and spoken English; ability to communicate with international teams.

Responsibilities

• Act as Parexel’s direct contact with assigned sites during start-up, ensuring quality and delivery.
• Build relationships with investigators and site staff.
• Conduct country-specific feasibility and site qualification activities.
• Prepare, negotiate, and facilitate regulatory documents and amendments.
• Submit IRB/IEC and MoH/RA applications and manage follow-ups.
• Support site access to study systems and ensure training compliance.
• Monitor site activity through initiation to close-out and optimize recruitment strategies.
• Maintain CTMS data timely and accurately.

Skills

Problem solving

Independent work

Presentation skills

Client focus

Interpersonal communication

Time management

Travel willingness

Education

Biological sciences / Pharmacy degree or equivalent

Job description

When our values align, there’s no limit to what we can achieve.
At Parexel, we all share the same goal - to improve the world’s health. From clinical trials to regulatory, consulting, and market access, every clinical development solution we provide is underpinned by something special - a deep conviction in what we do.

Each of us, no matter what we do at Parexel, contributes to the development of a therapy that ultimately will benefit a patient. We take our work personally, we do it with empathy and we’re committed to making a difference.

External Job Description

Key Accountabilities:

Start-up (from site identification through pre-initiation):

Act as Parexel’s direct point of contact with assigned sites, accountable for quality and delivery during the start-up phase.

• Build relationships with investigators and site staff.

• Conduct, drive and manage country specific feasibility and/or site pre-qualification and qualification activities, which may include:

• Preparation, negotiation, and facilitation of execution of Confidentiality Agreements (CDA), Clinical Site Agreements (CSAs) and any amendments.
• Conduct remote Qualification Visits (QVs).

• Generate visit/contact reports, using judgment to identify site issues and problem solving to direct resolution.

• Develop strategy to configure, distribute, and collect, and review and approve, high quality country specific and/or site specific documents or essential regulatory documents (SRP) and any updated or amended regulatory documentation.

• Customize, review, and negotiate as needed, country/site specific Informed Consent Forms (ICF), translations (within parameters of country/regulatory/client requirements), and customize and negotiate any amendments.

• Prepare and submit IRB/IEC and MoH/RA (if applicable) application(s), resolving conflicts, determining appropriate follow up until receipt of final approval.

• Submit all pertinent documentation to the trial master file as per project plans/sponsor/company policy.

• Forecast, develop, manage, and revise plans and strategies for:

• IRB/IEC and MoH / RA submission/approval,
• Site activation,
• Patient recruitment & retention.

• Update and maintain appropriate Clinical Trial Management systems (CTMS) in a timely manner.

• Promptly identify, use judgment and knowledge to address and resolve or elevate, any site question and/or issue, including but not limited to: potential issues or risks with site activation timelines, issues with patient recruitment strategy, deficiencies in training, data quality or integrity, study non-compliance, etc.

• Facilitate and support allocated sites with access to relevant study systems and ensure they are compliant with all project specific training requirements prior to study start.

• Actively participate in Investigator and other external or internal meetings, audits & regulatory inspections

• Work in a self-driven capacity, with limited need for oversight.

• Proactively keep manager informed about work progress and any issues.

Maintenance (from initiation through close out):

Act as Parexel’s direct contact with assigned sites, assess and ensure overall integrity of study implementation and adherence to study protocol at clinical sites, and perform problem-solving to address and resolve site issues.

• Build relationships with investigators and site staff.

• Facilitate and support site with access to relevant study systems and ensure sites are compliant with project specific training requirements.

• Evaluate if on-site staff assignment is still accurate and determine and implement corrective actions & follow-up, if necessary / relevant.

• Address and resolve issues at sites, including the need for additional training, potential deficiencies in documentation, and communication.

• Address/evaluate/resolve issues pending from the previous visit, if any.

• Follow-up on and respond to appropriate site related questions.

• Apply working knowledge and judgment to identify and evaluate potential data quality and data integrity issues. Determine and implement appropriate follow-up action.

• Actively participate in Investigator and other external or internal meetings and audits & regulatory inspections as required.

• Collect, review, and approve (if applicable) updated/amended site documentation, including regulatory documents as applicable.

• Evaluate site recruitment plan in collaboration with the site staff on an ongoing basis and provide strategy for improvements.

• Perform on-site visits; this includes Qualification and Initiation visits; apply judgment and knowledge to independently resolve site issues, questions and concerns.

• Conduct remote visits/contacts as requested/needed.

• Generate visit/contact report.

• Evaluate overall compliance and performance of sites and site staff: provide recommendations regarding site-specific actions and use judgment and experience to assess the ability and motivation of site staff.

• Assess & manage test article/study supply including supply, accountability and destruction/return status.

• Review & follow-up site payment status.

• Follow-up on CRF data entry, query status, and SAEs.

• Conduct on-site study-specific training (if applicable).

• Perform site facilities assessments

• Recognize impact of study non-compliance/issues/delays/changes on study timelines and communicate study issues that require immediate action, with proposed strategy for resolution

Overall Accountabilities from Site Identification to Close out:

Ensure timely and accurate completion of project goals and update of applicable trial management systems.

• Work with team members to meet project goals, provide strategy for efficient project planning and goal completion, and encourage the support of team members where required.

• Update all appropriate Clinical Trial Management Systems (CTMS) on an ongoing basis, including performing regular reviews of site level data in clinical systems (e.g. CTMS, EDC, IVRS, and SIS) and ensure timely and high quality data entry compliance from sites, manage and submit all relevant documents to the Trial Master File (TMF), ensuring first time quality, and distribute study documents to site including configuration of Investigator Site Files if applicable and on-going maintenance for completeness and quality.

• Ensure that assigned sites are audit and inspection ready

• Monitor and maintain compliance with ICH-GCP and applicable international and local regulations.

• Delegate administrative and other tasks to Administrative Support Team as needed and where appropriate. Guide Administrative Support Team members, review work, and provide feedback to manager regarding performance.

• Show commitment and perform consistent high quality work.

• Maintain a positive, results-orientated work environment, building partnerships and collaborative relationships, communicating with team(s) in an open, balanced, objective manner, modeling the high performance culture values.

• Maintain a working knowledge of and ensure compliance with applicable ICH-GCP Guidelines, international and local regulations, Parexel SOPs, other Parexel / Sponsor training requirements and study specific procedures, plans and training.

• Ensure basic understanding of project scope, milestones, budgets, and strive for high quality, timely, and efficient delivery.

• Provide input and feedback for Performance Development Conversation(s).

• Proactively keep manager informed about work progress and any issues.

• Develop expertise to become a subject matter expert.

• Work in a self-driven capacity, with limited need for oversight.

• Complete additional tasks in a timely manner (e.g. timesheets, expenses, metrics, etc.)

Skills:

• Problem solving skills

• Able to work independently, seeking/taking guidance when necessary.

• Sound presentation skills

• Client focused approach to work.

• Ability to interact professionally within a client organization with the support of manager or CRAII/III

• Flexible attitude with respect to work assignments and new learning.

• Ability to manage multiple tasks, to evaluate a variety of unpredictable scenarios, and achieve project timelines; apply understanding of study protocol(s).

• Willingness to work in a matrix environment and to value the importance of teamwork.

• Strong computer skills including but not limited to the knowledge of a Clinical Trial Management System (CTMS), Electronic Document Management System (EDMS), and MS-Office products such as Excel and Word.

• Sound interpersonal, verbal, and written communication skills.

• Sense of urgency in completing assigned tasks and ability to assist others to meet study/ country deliverables.

• Developing ability for effective time management in order to meet study needs, team objectives, and department goals.

• Developing ability to work across cultures.

• Shows commitment to and performs consistently high quality work.

• Ability to successfully work in a (‘virtual’) team environment.

• Able to accommodate travel time requirements, according to tasks allocation/phase of the study assigned.

• Attention to detail.

• Holds a driver’s license where required

Knowledge and Experience:

• Previous relevant work experience preferred.

Education:

• Educated to degree level (biological science, pharmacy, or other health-related discipline preferred) or equivalent nursing qualification or other equivalent experience