Senior Scientist in Translational Pathology, Oncology

ASTRAZENECA UK LIMITED; Hartford; On-site; GBP 55,000 - 80,000; Full time

Job summary

A leading biopharmaceutical company is seeking a Senior Scientist in Hartford, United Kingdom. This role focuses on translational science in oncology, influencing novel therapeutics' clinical development. Candidates must possess a PhD and relevant experience in the field, especially in biomarker assay development. The company promotes a collaborative office environment while allowing for individual flexibility.

Qualifications

• PhD plus at least 2 years experience in industry.
• Knowledge in AZ portfolio areas like tumor drivers and resistance.
• Skilled in development and validation of biomarker assays.

Responsibilities

• Influence clinical development of novel therapeutics.
• Collaborate across global boundaries in cancer research.
• Lead innovative solutions from the bench.

Skills

PhD in a relevant field

Experience in immuno-oncology

Skills in biomarker assays development

Experience in microscopy

Strong problem-solving abilities

Education

PhD

Job description

Overview

Are you ready to be at the cutting edge of translational science in oncology? Join AstraZeneca's Translational Pathology group within the Oncology R&D Cancer Development Biomarker department as a Senior Scientist! Here, you'll have the chance to influence an industry-leading portfolio, from early clinical development of novel therapeutics to post‑marketing opportunities for approved targeted therapies. Collaborate across global boundaries and make a real impact in the fight against cancer!

Requirements

• PhD plus at least 2 years experience in industry/a relevant field.
• Knowledge in one or more AZ portfolio areas: tumor drivers and resistance, DNA damage response (DDR), immuno‑oncology (IO), epigenetics or antibody drug conjugates (ADC).
• Skilled in development and validation of biomarker assays.
• Experience in manual or automated immunohistochemistry (IHC) (brightfield or fluorescence).
• Experience in microscopy and carrying out digital image analysis.
• Ability to lead from the bench in problem solving and the development of innovative solutions.
• Peer‑reviewed publications in the field of translational pathology or cancer biology.

Desirable Skills / Experience

• Expertise in one or more AZ portfolio areas, including related biology and knowledge of translational approaches to developing therapeutics for cancer.
• Experience working with human tissues and tissue‑based histopathology methods.
• Experience of conducting studies for Good Clinical Practice (GCP).
• Skills in developing multiplexed IHC or in situ hybridization (ISH) assays.
• Career exposure to the pharmaceutical industry and the drug development process.

Working Environment

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life‑changing medicines. In‑person working gives us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn’t mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Company Vision

AstraZeneca offers an unparalleled opportunity to work with one of the broadest and deepest Oncology pipelines in the industry. Our commitment to transforming cancer treatment is driven by a science‑based approach and a vision to eliminate cancer as a cause of death. Collaborate with top experts globally, engage with diverse perspectives, and be empowered to innovate and take smart risks. Together, we challenge norms and push boundaries to make a meaningful difference for patients worldwide.