Senior Scientist I - Protein Purification & Automation

Cyprotex; Alderley Edge; On-site; GBP 70,000 - 100,000; Full time

Benefits offered by this job

Pension scheme

25 days holiday

Private health insurance

Dental cover

Wellbeing support

Bonus scheme

Career progression

Cycle-to-work

Onsite parking

Job summary

Evotec is seeking a Senior Scientist for Protein Purification & Automation at Alderley Park. You will design, lead, and scale automated purification workflows to deliver high-quality protein for drug discovery.

The role requires deep hands-on expertise with ÄKTA chromatography, high-throughput platforms, and integration with LIMS. You will guide multiple projects, contribute to digital workflows, and mentor team members in a fast-paced environment.

Qualifications

• Extensive experience in recombinant protein purification.
• High-throughput purification strategies through automation and scale-up.
• Experience with difficult protein targets (unstable, aggregation-prone).
• Hands-on experience with chromatography systems (ÄKTA) and liquid handling/automation platforms.
• Proven track record of designing and optimising purification workflows end-to-end.
• Experience delivering high-quality protein and data under tight timelines.
• Programming or scripting skills (e.g., Python) for automation and data processing.

Responsibilities

• Design, optimise, and execute purification workflows across multiple scales.
• Lead development of high-throughput purification platforms, including automated workflows.
• Purify challenging, unstable proteins using advanced strategies.
• Integrate purification with expression and characterisation pipelines.
• Develop purification workflows using liquid handling systems and ÄKTA platforms.
• Drive automation of complex, multi-step purification processes.
• Contribute to digital workflows (LIMS, data capture).
• Leverage Python to enhance automation and data processing.
• Lead projects and mentor internal resources.

Skills

High-throughput purification

Automation platforms

ÄKTA chromatography

Python scripting

Protein purification

LIMS integration

Data handling

Drug discovery

Team leadership

Education

Ph.D. or equivalent in relevant field

Tools

ÄKTA

Liquid handling systems

Job description

We are seeking a highly skilled and innovative Senior Scientist to join our Protein Biochemistry team, with a primary focus on protein purification and automation at scale.

This role requires deep technical expertise in high-throughput purification workflows, including the handling of complex, aggregation-prone, and otherwise difficult to purify proteins. You will play a key role in designing, implementing, and scaling automated purification platforms, while ensuring delivery of high-quality protein and data to support drug discovery programs. Through hands-on scientific leadership, you will drive multiple projects simultaneously and contribute to advancing both platform capabilities and scientific excellence

Job Title: Senior Scientist Protein Purification & Automation

Job Type: Permanent

Location: Alderley Park, Macclesfield, SK10 4TG

Our Company

Evotec is a leader in the discovery and development of novel small molecule drugs with operational sites in Europe and the US. The Company has built substantial drug discovery expertise and an industrialised platform that can drive new innovative small molecule compounds into the clinic. In addition, Evotec has built a deep internal knowledge base in the treatment of diseases related to neuroscience, pain, oncology, inflammation and metabolic diseases. Leveraging these skills and expertise the Company intends to develop best-in-class differentiated therapeutics and deliver superior science-driven discovery alliances with pharmaceutical and biotechnology companies

Key Accountabilities

• Design, optimise, and execute robust protein purification workflows (manual and automated) across multiple scales.
• Lead development of high-throughput purification platforms, including multi-step automated workflows.
• Apply advanced strategies to purify challenging, unstable, aggregation-prone, or low-yield proteins.
• Integrate purification workflows with expression and characterisation pipelines to maximise throughput and data quality.
• Develop and implement protein purification workflows using liquid handling systems and ÄKTA platforms.
• Drive automation of complex, multi-step purification processes.
• Contribute to digital workflow development (e.g., LIMS integration, data capture, traceability).
• Leverage programming (e.g., Python or equivalent) to enhance automation, data handling, and process optimisation.
• Design and implement protein characterisation strategies (e.g., purity, stability, aggregation, activity).
• Ensure high-quality, quality controlled, reproducible data generation and documentation.
• Responsible for supporting multiple projects and may be asked to direct internal resources efficiently to achieve agreed goals.
• Where responsible for reports, will lead colleagues to co-develop plans for personal growth, aligned to business need.
• Represent the company at scientific and/or business conferences.
• Presents and publishes as appropriate peer-reviewed science increasing own and Evotec’s scientific reputation.

Knowledge & Experience

• Extensive experience in recombinant protein purification, with clear expertise in:
• High-throughput purification strategies through automation and scale-up
• Extensive experience with difficult protein targets (unstable, aggregation-prone)
• Strong hands-on experience with chromatography systems (e.g., ÄKTA) and Liquid handling / automation platforms supporting protein purification workflows
• Proven track record of designing and optimising purification workflows end-to-end.
• Experience delivering high-quality protein and data under tight timelines.
• Strong understanding of protein biochemistry within drug discovery workflows.
• Demonstrated ability to solve complex technical problems and troubleshoot purification challenges.
• Experience in working with cell free expression systems is desirable
• Programming or scripting skills (e.g., Python) for automation and data processing and familiarity with LIMS and digital lab workflows.
• Experience with in silico-based tools for sequence and structural analysis is desired.
• Experience of preparing and executing workplans and building trusted partnership with internal and external customers.Requires a track record of leading scientists across specialist fields.
• Requires a track record of facilitating employee growth through co-development of personal development plans.
• Track record of successful problem-solving, high-quality science and influencing of stakeholders and colleagues.
• Experience of scientific development and research work ideally with publications in a relevant scientific field.

Education and Qualifications

• Ideally a Ph.D. degree or corresponding experience in a relevant scientific discipline with > 5 years of relevant experience in industry. Alternatively, a relevant first degree and several years additional experience in drug discovery.

Evotec Leadership Competencies

Active Communication: Communicates actively, working on further clarity and responsiveness

Constructive Feedback: Actively seeks and provides constructive feedback, using it to improve processes and outcomes

Consistent Team Engagement: Engages frequently, fostering a more positive and collaborative environment

Foundational Direction Sharing: Communicates pragmatic directions, leading to general understanding and alignment

Planning: Anticipates problems and improves on proactively taking precautions

Effective Delegation: Delegates tasks effectively, trusting team members to handle responsibilities and providing necessary support and development

Benefits Package

• Pension on completion (but not subject to) of your 3-month probationary period. Contributions 5% for employees (salary sacrifice) and 5% for the employer. The employee can opt to increase their contribution, and the employer will match the increase up to a maximum of 7.5%.
• 25 days holiday plus bank holidays and additional length of service days awarded on the anniversary, up to a maximum of 30 days
• Private health insurance with BUPA for the employee and their partner/family under the company scheme
• Well being support 24/7 and counselling services
• Permanent health insurance provides 75% of the base salary after the qualifying period
• Private dental cover, on completion (but not subject to) of your 3-month probationary period
• Eligibility to participate in the Company Bonus Scheme. This is a discretionary benefit.
• Career progression within the company, we have excellent training and support and continuing professional development opportunities
• Cycle-to-work scheme
• Refer a friend scheme, team and annual events, recognition awards and many more!

Onsite Facilities

• The company pays for secure onsite parking
• Restaurant, Café, and Gastro pub
• Gym and workout studio, running, walking, and cycling routes
• Good public transport links with the shuttle bus service.

FR : Dans le cadre de sa politique Diversité, Evotec étudie, à compétences égales, toutes les candidatures dont celles des personnes en situation de handicap.

ENG : In the frame of our Diversity policy, Evotec considers, with equal competences, all applications including people with disabilities.