Senior Scientist I - Characterisation | CMC - Oxford in Oxford

Energy Jobline ZR; Oxford; On-site; GBP 40,000 - 60,000; Full time

Job summary

A leading biotechnology company in Oxford is seeking a Senior Scientist I to focus on the characterisation of biotherapeutic molecules. This role involves supporting drug characterization, performing critical analysis using advanced techniques, and contributing to the development of methods for precise drug profiling. Candidates should have a background in biochemistry, experience with mass spectrometry, and a proven track record in laboratory environments.

Qualifications

• Experience in development of HPLC based peptide mapping methods.
• Expert in mass spectrometric characterisation of recombinant proteins.
• Worked in a bench-based biopharmaceutical laboratory environment.

Responsibilities

• Support drug substance and drug product impurity characterisation.
• Perform protein sequence and modification identification.
• Contribute to characterisation methods development.

Skills

HPLC methods development

Mass spectrometry

Glycosylation analysis

Team collaboration

Analytical problem solving

Education

BSc or MSc in biochemistry

PhD in related discipline

Tools

HPLC

Mass spectrometer

Job description

Overview

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Senior Scientist I - Characterisation | CMC - Oxford

Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry's most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.

Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases. At Immunocore, we recognize that our employees are our greatest asset.

We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, , and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared and drives our mission.

We are dedicated to developing breakthrough therapies that transform patients' lives, advancing medicine, and supporting one another in these pursuits. Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered.

We encourage applications from individuals of all backgrounds, regardless of , , religion, sex, , gender or expression, , , , status, or any other characteristic protected by law.

To characterise the companies biotherapeutic recombinant T-cell receptor based and related molecules using a wide variety of protein characterisation and mass spectrometry methods. To contribute to the development of characterisation methods for the company's biopharmaceutical products, including peptide mapping (LC-MS/MS) and intact mass spectrometry analysis.

Responsibilities

• Supporting drug substance and drug product impurity characterisation and identification
• Performing protein sequence and post translational modification identification, including glycosylation analysis
• Supporting drug substance and drug product process development by performing characterisation of process intermediates
• Contribute to the Development of characterisation methods of ImmTAX and other products, including peptide mapping (LC-MS/MS) and intact mass analysis
• Designing and carrying out biochemical characterisation, chemical stability and comparability studies of biologics/drug products
• Contribute to writing study protocols and reports
• Independently testing and, increasingly, leading lines of investigation; proposing new experiments based on emerging data and other related information
• Providing support on technical aspects to others
• Priorities: establishing priorities for own work and team-based projects; making decisions on prioritisation based on the overall goals of the team, department and project
• Technical Knowledge: sharing knowledge with the wider team and, across departments representing the department
• May act as a mentor to other colleagues
• Providing analysis of new techniques and theories from outside the Company to advance the way the company works
• Laboratory records: ensuring that all records and information are up to date, on time and recorded to the correct standard
• Adhere to safe working practices in laboratories according to Immunocore EHS policies

Qualifications

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies
• Experience of glycosylation analysis of recombinant proteins or antibodies
• Independently coordinated extensive testing of protein biomolecules
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems
• Understanding of expected post-translational modifications in biological systems
• Worked in a bench-based biopharmaceutical laboratory environment
• Established as an expert amongst peers in electrophoretic, chromatographic or mass spectrometry
• Experienced in assay development
• Familiar with biopharmaceutical stability study principles and interpretation
• Worked and contributed actively in a diverse team environment
• Proposed and driven changes in working practices that have improved efficiency
• Presented detailed scientific findings and papers to internal and external audiences

Education & qualifications

• Essential: BSc or MSc in biochemistry, biotechnology or related discipline
• Desirable: PhD in related discipline

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