Senior Principal Scientist

Cancer Research UK; Cambridge; Hybrid; GBP 58,000 - 76,000; Full time

Benefits offered by this job

Benefits package

Job summary

Cancer Research UK is seeking a Senior Principal Scientist in Therapeutic Translation to evaluate CRUK’s research portfolio and identify translational opportunities across national and international collaborations. You will shape hypotheses, collaborate with PIs, and drive strategic interventional funding to accelerate cancer therapeutics.

The role requires deep translational insight, strong networking abilities, and a track record in translating discovery biology into medicines.

Qualifications

• PhD or equivalent in a relevant discipline with oncology drug discovery experience.
• Expertise in identifying and developing small molecule therapies and/or biotherapeutics.
• Understanding of the drug development pipeline from discovery to clinical development.

Responsibilities

• Support the implementation of the Therapeutic Translation strategy.
• Identify translational opportunities from current CRUK-funded research.
• Collaborate with PIs, CRUK Institutes, and international partners to evaluate opportunities.
• Perform detailed reviews of opportunities and shape new hypotheses and proposals.
• Signpost translational schemes and assist EOIs and TI collaborations.
• Promote the Therapeutic Translation team's visibility within the research community.

Skills

Drug discovery

Small molecules

Biotherapeutics

Target validation

Preclinical models

Academic collaboration

Education

PhD or equivalent

Job description

Senior Principal Scientist (Therapeutic Translation)£58,400 - £76,000 plus benefitsDepartment: Therapeutic Innovation - R&IReports to: Chief Scientific OfficerLocation: Babraham Research Campus, Cambridge with high flex (1 to 2 days per week on site).Contract type/hours: Permanent, Full-time 35 hours per week (flexible working requests will be considered).Closing date: Sunday 18th October 23:55pmInterview Date: To be confirmed.Interview process: Competency-based interview process with task/presentation.At Cancer Research UK, we exist to beat cancer.At Cancer Research Horizons (CRH) our Therapeutic Innovation team is investing in a world‑leading capability to translate breakthrough discovery science into the next generation of oncology therapeutics. As part of this evolution, we have established a new Therapeutic Translation team. A group of experienced oncology drug discoverers dedicated to identifying, shaping, and accelerating the most exciting science emerging from the CRUK research ecosystem. Every role at CRH is united by a single mission: beating cancer sooner. We carry out work that matters - impacting patients, families, and the future of science.As a Senior Principal Scientist, you will play a pivotal role in evaluating the breadth of CRUK’s research portfolio, as well as emerging scientific areas with strong therapeutic potential. Working across CRUK Institutes, Centres, and international academic collaborations, you will build trusted relationships with scientific leaders to uncover early‑stage ideas with the potential to become validated, fundable therapeutic concepts.This is an outward‑facing, high‑visibility role that requires deep scientific insight, strategic judgement, and a natural curiosity for uncovering translational opportunity before it becomes obvious. You will help transform breakthrough biology into new medicines for cancer patients, shaping not only individual projects, but the future direction of CRUK‑funded oncology research itself.This position offers a rare opportunity for an accomplished drug hunter to influence therapeutic innovation on a national scale and support the discovery of tomorrow’s cancer therapies. You’ll be joining over 200 staff across CRH from both industrial and academic backgrounds, all dedicated to bringing forward the day we cure cancer.What will you be doing?Support the implementation of a new Therapeutic Translation strategy for CRH TI to enhance the number of therapeutic opportunities identified from CRUK funded research.Maintain awareness of emerging areas of cancer biology and technological advances relevant to the objectives of CRH TI in order to identify and recommend priority translational opportunities for examination or investment.Analyse current and future CRUK funded research to highlight key translational opportunities.Work with CRUK PIs, Research Institutes and Centres, within the UK and internationally (CRUK/NCI Grand Challenges or Academic Alliances) to identify translational opportunities.Perform detailed reviews of opportunities identified.Shape new hypotheses and collaborative proposals in partnership with PIs.Signpost the Therapeutic Catalyst scheme and assist the development and submission of EOI proposals.Propose translational opportunities for strategic interventional funding.Propose opportunities for consideration as TI collaborations and for experimental validation by TI’s Portfolio Generation.Promote the visibility of the Therapeutic Translation team in the academic research community and life science sector.What are we looking for?PhD or equivalent in a relevant discipline (e.g. Bioscience, Chemical Biology) with previous experience of working on oncology drug discovery in industry.You will have expertise in identifying and developing small molecule therapies and/or biotherapeutics, with an awareness of alternative therapeutic modalities.A good understanding of mechanistic cancer biology, current therapeutic approaches in oncology, and personalised medicine strategies applied to cancer treatment.A good understanding of translating opportunities from a target concept to a therapeutic, including relevant target validation methods and the use of preclinical models.Previous experience of working productively with or within the academic sector on translational/therapeutic projects.Knowledge of the broad drug development pipeline, from Target Identification through to clinical development.Excellent interpersonal skills with the ability to network and build strong working relationships.Excellent written and verbal communication skills.Strong and collaborative team player.Self-motivated individual with excellent time-management skills, able to prioritise workload and deliver to tight deadlines.Our organisation values are designed to guide all that we do.Bold: Act with ambition, courage and determinationCredible: Act with rigour and professionalismHuman : Act to have a positive impact on peopleTogether: Act inclusively and collaborativelyWe’re looking for people who can believe in and embody these organisation values and can use them to drive forward progress against our mission to beat cancer.If you’re interested in applying and excited about working with us but are unsure if you have the right skills and experience, we’d still love to hear from you.What will I gain?We create a working environment that supports your wellbeing and provide a generous benefits package, a wide range of career and personal development opportunities and high-quality tools. Our policies and processes enable you to improve your work-life balance and take positive steps in your career.You can explore our benefits by visiting our careers web page .How do I apply?We operate an anonymised shortlisting process in our commitment to equality, diversity and inclusion. CVs are required for all applications; but we won’t be able to view them until we invite you for an interview. Instead, we ask you to complete the work history section of the online application form for us to be able to assess you fairly and objectively.For more information on this career opportunity please visit our website or contact us at [e-mail] .For more updates on our work and careers, follow us on: Linked In , Facebook , Instagram , X and YouTube .Our vision is to create a charity where everyone feels like they belong, benefits from and participates in, the work we do. We actively encourage applications from people of all backgrounds and cultures, in particular those from ethnic minority backgrounds who are currently under-represented.We want to see every candidate performing at their best throughout the job application process, interview process and whilst at work. We therefore ask you to inform us of any concerns you have or any adjustments you might need to enable this to happen. Please contact [e-mail] or 0 20 3469 8400 as soon as possible.Unfortunately, we are unable to recruit anyone below the age of 18, so that we can protect young people from health & safety and safeguarding risks.