Senior Medicinal Chemist - Drug Discovery & Synthesis

Placements24; Southampton; On-site; GBP 45,000 - 63,000; Full time

Benefits offered by this job

Competitive salary

Health benefits

Retirement plan

Performance incentives

Growth opportunities

Job summary

Placements24 is assisting a distinguished pharmaceutical research company in locating a Senior Synthetic Organic Chemist for their Randburg, Gauteng facility. The role centers on designing and executing complex multi-step syntheses of novel small molecules and drug candidates, with close collaboration with medicinal chemists on SAR and structure-activity relationships.

You will purify products, characterize them by NMR, MS and IR, and maintain meticulous lab notebooks while adhering to safety

Qualifications

• PhD in Organic Chemistry or closely related field.
• 6+ years of postdoctoral or industry experience in synthetic organic chemistry with focus on medicinal chemistry.
• Expertise in designing and executing complex multi-step syntheses.

Responsibilities

• Design and implement efficient synthetic routes for target molecules.
• Perform reactions from milligram to multi-gram scale.
• Purify synthesized compounds using chromatographic techniques (flash chromatography; HPLC).
• Characterize synthesized compounds using spectroscopic methods (NMR; MS; IR).
• Troubleshoot synthetic challenges and optimize reaction conditions.
• Collaborate with medicinal chemists to iterate on SAR.
• Maintain detailed laboratory notebooks.
• Stay updated on advancements in synthetic organic chemistry and literature.
• Ensure compliance with laboratory safety protocols.
• Contribute to patent filings and publications.

Skills

Multi-step synthesis

Medicinal chemistry

SAR collaboration

NMR

MS

IR

Problem solving

Communication skills

Air-sensitive handling

Education

PhD in Organic Chemistry

Tools

Flash chromatography

HPLC

NMR spectroscopy

MS

IR

Job description

Placements24 is assisting a distinguished pharmaceutical research company in locating a Senior Synthetic Organic Chemist for their Randburg, Gauteng facility. The role centers on designing and executing complex multi-step syntheses of novel small molecules and drug candidates, with close collaboration with medicinal chemists on SAR and structure-activity relationships.

You will purify products, characterize them by NMR, MS and IR, and maintain meticulous lab notebooks while adhering to safety