Senior Medical Director, Oncology Clinical Development - Sarcoma

GlaxoSmithKline; Greater London; On-site; GBP 180,000 - 240,000; Full time

Job summary

GlaxoSmithKline is seeking a Senior Medical Director, Oncology Clinical Development – Sarcoma, to provide medical oversight across study design, conduct and data interpretation. You will partner with cross-functional teams to integrate physician expertise into programme delivery, ensuring patient safety and clinical integrity across studies.

The role involves regulatory interactions, external scientific engagement, and leadership within the Clinical Matrix Team, driving strategic medical

Qualifications

• Medical degree and completion of advanced specialty training, fellowship or country-equivalent higher-level qualification in medical oncology, pediatric oncology or hematology.
• Experience in sarcoma oncology, including leading drug development.
• Clinical and pharmaceutical experience in oncology clinical development, with depth across multiple studies or programmes.
• Experience in medical monitoring, safety evaluation, and clinical data interpretation across clinical studies.
• Understanding of clinical development processes, GCP, ICH guidelines, and global regulatory frameworks.
• Experience operating within cross-functional matrix teams and contributing to complex clinical and programme-level decisions.

Responsibilities

• Provide medical oversight across study design, conduct, and data interpretation within the oncology programme.
• Guide medical monitoring and safety oversight across studies with patient safety at the centre.
• Engage with investigators and external experts to support scientific exchange and regulatory interactions.
• Lead or contribute to protocol development and study design ensuring clinical relevance.
• Serve as a senior member of the Clinical Matrix Team influencing cross-functional decisions.
• Mentor Medical Directors and support capability development within Oncology Clinical Development.

Skills

Clinical Data Interpretation

Clinical Pharmacology

Clinical Trial Designs

Clinical Trials Monitoring

Digital Fluency

Drug Development

Drug Regulatory Affairs

Evidence Based Decision Making

Executive Presence

Hematology and Oncology

Learning Agility

Matrix Leadership

Real World Evidence

Scientific Presentations

Strategic Direction

Education

Medical degree and advanced specialty training in medical oncology/pediatric oncology/hematology

Job description

For candidates seeking to be located at our Stevenage site, this role will temporarily be based at Stevenage. However, the Company plans to relocate its offices to Cambridge, UK. The location of this role will therefore subsequently change to Cambridge, UK in accordance with timelines to be set by the Company. The relocation is currently proposed to take effect by early 2029 .The Senior Medical Director, Oncology Clinical Development – Sarcoma, is a senior physician leader within the clinical programme team, providing medical oversight, strategic clinical insight, and a patient-centred perspective across the design, conduct, and interpretation of clinical studies. This role ensures that medical considerations, patient safety, and clinical integrity are consistently applied across studies within a programme.Operating within the clinical strategy defined by the Clinical Development Lead (CDL), the Senior Medical Director partners closely with the Senior Scientist and cross-functional teams to guide the integration of physician expertise into study execution and programme-level decision-making. The role serves as a senior member of the Clinical Matrix Team (CMT), contributing to complex clinical decisions, regulatory interactions, and external scientific engagement.The Senior Medical Director provides matrixed oversight to the clinical team within the programme, supporting consistency of clinical judgement, safety evaluation, and medical interpretation across studies.PLEASE NOTE: This career opportunity requires an on-site office presence (minimum of two days a week) at one of GSK’s Switzerland (Zug), UK (Stevenage or London HQ) or US (PA or MA) sites.In This Role You Will:Serve as a senior physician leader within the clinical programme, providing medical oversight and clinical insight across study design, conduct, and data interpretationProvide guidance on medical monitoring and safety oversight across studies, ensuring consistent application of clinical judgement and patient safety standardsInterpret complex clinical and safety data, generating insights that inform programme-level decisions led by the CDLPartner with the Senior Scientist and cross-functional teams to ensure medical considerations are integrated across study execution and programme deliveryProvide senior medical input into protocol development and study design, ensuring clinical relevance and patient-centred design within the clinical strategy defined by the CDLServe as a senior member of the CMT, influencing study-level and programme-level decision-makingEngage with investigators, Key External Experts (KEEs), and scientific leaders to support external engagement and represent the programme at advisory boards, steering committees, and scientific forumsProvide medical guidance and mentorship to Medical Directors within the programme, supporting consistency and development of clinical capabilityDetailed Responsibilities:Medical Monitoring and Safety Oversightconsistency in approach, patient safety, and protocol adherenceGuide interpretation of safety data in collaboration with pharmacovigilance, supporting signal detection, escalation, and benefit–risk evaluation across the programmeParticipate in and contribute to safety review forums (e.g., SRT, IDMC), providing senior physician perspective on complex safety questionsEnsure medical monitoring approaches are aligned across studies and consistent with regulatory and organisational standardsStudy Design and ExecutionProvide senior medical input into protocol development across studies, ensuring clinical relevance, feasibility, and alignment with the clinical strategy defined by the CDLGuide clinical aspects of study design and protocol implementation, particularly for complex, high-risk, or multi-study programmesSupport resolution of complex medical questions arising during study conduct, applying clinical judgement to inform programme-level decision-makingEnsure consistency of medical considerations across multiple studies within the programmeData Interpretation and Scientific ContributionInterpret complex clinical data across studies, integrating findings to inform programme-level insights on safety, efficacy, and patient impactContribute to programme-level data interpretation and support CDL-led benefit–risk assessment and clinical positioningGuide development of scientific communications, including publications, congress materials, and clinical summariesMaintain deep understanding of disease biology, evolving treatment paradigms, and competitive landscape to inform clinical interpretation and programme strategyRegulatory and External EngagementContribute senior medical expertise to regulatory interactions and Health Authority discussions, including responses to complex clinical and safety queriesRepresent the programme at advisory boards, steering committees, and external scientific forums, providing senior physician perspective on clinical data and programme directionEngage with KEEs and scientific collaborators to support programme development, scientific exchange, and external credibilityLead or contribute to the clinical and technical diligence assessment of business development opportunitiesCross-Functional Collaboration and Clinical Matrix TeamServe as a senior member of the Clinical Matrix Team (CMT), influencing cross-functional alignment and programme-level decision-makingContribute medical expertise to disease area strategy, integrated evidence planning, and Medical Affairs discussionsCollaborate across functions to ensure alignment on safety, data interpretation, and clinical positioning across the programmeLead or contribute to Oncology Clinical Development-wide initiatives and workstreamsPeople Leadership & Capability DevelopmentProvide oversight, guidance, and mentorship to clinical scientists within the programme, supporting consistency and quality of medical input across studiesSupport development of clinical capability within the medical team, including coaching on medical monitoring, data interpretation, and external engagementContribute to talent development, performance discussions, and capability building within Oncology Clinical DevelopmentBasic Qualifications:Medical degree and completion of advanced specialty training, fellowship or country-equivalent higher-level qualification in medical oncology, pediatric oncology or hematology.Experience in sarcoma oncology, including leading drug development.Clinical and pharmaceutical experience in oncology clinical development, with depth across multiple studies or programmesExperience in medical monitoring, safety evaluation, and clinical data interpretation across clinical studiesUnderstanding of clinical development processes, GCP, ICH guidelines, and global regulatory frameworksExperience operating within cross-functional matrix teams and contributing to complex clinical and programme-level decisionsPreferred Qualifications:Deep expertise in soft tissue sarcoma and osteosarcoma, including experience leading or supporting clinical development programs across early and/or late-stage clinical studies.Strong scientific communication and stakeholder engagement skills, with the ability to influence internal and external audiencesDeep experience in oncology clinical development across multiple studies or programmes, including Phase I–IIIExperience contributing to or leading aspects of regulatory interactions (e.g., IND, scientific advice, NDA/MAA)Demonstrated experience engaging with KEEs, advisory boards, and scientific communities in oncologyTrack record of scientific publications and congress presentationsDeep understanding of oncology disease biology and the evolving treatment landscape across solid tumours and/or haematological malignanciesExperience contributing to clinical and technical diligence for business development opportunitiesSkillsClinical Data Interpretation, Clinical Pharmacology, Clinical Trial Designs, Clinical Trials Monitoring, Digital Fluency, Drug Development, Drug Regulatory Affairs, Evidence Based Decision Making, Executive Presence, Hematology and Oncology, Learning Agility, Matrix Leadership, Real World Evidence (RWE), Scientific Presentations, Strategic Direction• If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $284,250 to $473,750. The US salary ranges take into account a number of factors including work location within the US market, the candidate’s skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process.Why GSK?Uniting science, technology and talent to get ahead of disease together.GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.GSK is an Equal Opportunity Employer. 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