Senior Data Scientist (Single Cell)

Relation Therapeutics; Greater London; On-site; GBP 90,000 - 130,000; Full time

Job summary

Relation Therapeutics in London is seeking a Senior Data Scientist to build the next generation of generative and predictive models of cellular behaviour, focusing on single-cell multi-omics. Your work will be central to understanding cellular decision-making and enabling novel therapeutic strategies grounded in generative models.

You’ll join a team with access to cutting-edge multiomic datasets, advanced computational infrastructure, and interdisciplinary expertise, contributing to publications

Qualifications

• A PhD (or equivalent) in computational biology, bioinformatics, or related field.
• Deep hands-on experience processing and analysing large-scale single-cell multiomics data, ideally including paired RNA + ATAC.
• Proficiency with single-cell analysis toolkits (scverse) and workflow frameworks (Nextflow, Snakemake).
• Experience with arrayed CRISPR perturbation screen data and QC, including MOI estimation and single-cell effect quantification.
• Proficiency in Python and familiarity with HPC environments.
• Strong communication skills to bridge experimental and ML teams across a fast-moving programme.
• Bonus Experience: integrating multiple data modalities (transcriptomics, chromatin accessibility, imaging and proteomics).
• Experience with foundation model development or perturbation prediction models.

Responsibilities

• Process and QC paired single-cell RNA-seq and scATAC-seq at scale across perturbations and contexts.
• Develop and maintain Nextflow pipelines with combinatorial indexing chemistries and methods like STARsolo, Alevin-fry, Chromap, and SnapATAC2.
• Integrate scRNA-seq and scATAC-seq with proteomics and imaging to build multimodal datasets.
• Manage data in memory-efficient formats (e.g. Zarr) for GPU-accelerated processing and model training at scale.
• Partner with wet lab scientists from design to interpretation to maximize data value.
• Contribute to evaluation frameworks to test ML models against biology and benchmarks.
• Collaborate with ML modellers to develop model architectures.
• Present findings to internal stakeholders and contribute to publications.

Skills

PhD or equivalent

Single-cell multiomics

Python

Nextflow

Snakemake

scverse

High-performance computing

Communication skills

Education

PhD or equivalent

Tools

Nextflow

Snakemake

Alevin-fry

STARsolo

Chromap

SnapATAC2

Zarr

Python

scverse ecosystem

Job description

About Relation

Relation is a sector defining TechBio company developing transformational medicines, with technology at our core. Our ambition is to understand human biology in unprecedented ways, discovering therapies to treat some of life’s most devastating diseases. We leverage single-cell multi-omics from patient tissue, functional assays, and machine learning to drive disease understanding, from cause to cure.

We are scaling rapidly and building a team of exceptional individuals to push the boundaries of drug discovery. You will work in highly interdisciplinary teams where biology, computation, and engineering come together to solve complex problems that have not been solved before. Our state-of-the-art wet and dry labs in the heart of London are designed to accelerate this integration and translate insight into impact.

We are committed to building diverse and inclusive teams. Relation is an equal opportunities employer and does not discriminate on the basis of gender, sexual orientation, marital or civil partnership status, gender reassignment, race, colour, nationality, ethnic or national origin, religion or belief, disability, or age.

By joining Relation, you will help define how medicines are discovered and deliver meaningful impact for patients.

The opportunity

Relation is offering an outstanding opportunity for a Senior Data Scientist to help build the next generation of generative and predictive models of cellular behaviour, with a focus on single cell multi-omics. Your work will be central to our mission to understand and control cellular decision‑making, enabling novel therapeutic strategies grounded in generative models.

You’ll be joining a team with access to cutting-edge multiomic and interventional datasets, advanced computational infrastructure, and deep interdisciplinary expertise, and a culture that embraces modern ML tooling, including agentic workflows, to accelerate research iteration. You will contribute advanced data analysis and domain expertise to challenge ML models that aim to predict and explain cellular decision‑making in disease.

Day to day, you will

• Process and QC paired single-cell RNA‑seq and scATAC‑seq at scale from thousands of perturbations across diverse cell types and biological contexts.

• Develop and maintain Nextflow pipelines compatible with custom combinatorial indexing chemistries and including methods such as STARsolo, Alevin‑fry, Chromap, and SnapATAC2.

• Integrate scRNA‑seq and scATAC‑seq with extracellular proteomics and high‑content imaging to build multimodal training datasets.

• Manage data in memory‑efficient formats (e.g. Zarr) for GPU‑accelerated processing and model training at scale.

• Partner closely with wet lab scientists from screen and cohort design through to interpretation, so experiments are analytically tractable and pipelines maximise data value.

• Contribute to the evaluation framework that determines whether ML models capture meaningful biology: design metrics, held‑out benchmarks, and biological sanity checks.

• Collaborate closely with ML modellers to develop model architectures.

• Present findings and methodologies to internal stakeholders and contribute to publications.

Professionally, you will have

• A PhD (or equivalent industry experience) in computational biology, bioinformatics, or a related quantitative field.

• Deep hands‑on experience processing and analysing large‑scale single‑cell multiomics data, ideally including paired RNA + ATAC (10x Multiome or equivalent).

• Proficiency with single‑cell analysis toolkits (e.g. scverse ecosystem) and workflow management frameworks (Nextflow, Snakemake).

• Experience with arrayed CRISPR perturbation screen data, including well‑level perturbation assignment via sample hashing, perturbation‑specific QC (e.g. MOI estimation), and single‑cell effect quantification.

• Proficiency in Python and familiarity with high‑performance computing environments.

• Strong communication skills to bridge experimental and ML teams across a fast‑moving programme

  Bonus Experience:

• Experience integrating multiple data modalities (transcriptomics, chromatin accessibility, imaging and proteomics) for joint analysis.

• Exposure to foundation model development or perturbation prediction models.

• A background in statistical modelling and algorithm development.

• Experience working in interdisciplinary teams.

Personally, you

• Are comfortable working in a matrixed environment,balancing multiple stakeholdersand contributing effectively across teams.

• Takeownership of your work, proactively seek opportunities to contribute, and enable others to do their best work.

• Communicate openly and directly, give and receive feedback constructively, and handle challenging conversations with respect.

• Actively seek out diverse perspectives, build strong working relationships, and contribute to shared goals across teams.

• Embrace challenges with openness and resilience, set high standards for yourself, and strive to deliver meaningful outcomes.

Working Style & Culture at Relation

At Relation, we operate in amatrixed, interdisciplinary environment, where impact is driven through collaboration across scientific, technical, and operational domains. We collaborate, and you will partner with colleagues across multiple teams and projects, contributing your expertise while aligning to shared company priorities. We work together and win together!The patient is waiting!