Senior Clinical Statistical Programmer (Portfolio Development / Biometrics / Programming)

CSL Plasma Inc.; Thatcham; Hybrid; GBP 70,000 - 100,000; Full time

Job summary

CSL Seqirus in Maidenhead is seeking a Senior Clinical Statistical Programmer to take technical ownership of one or two trials from first line code to submission-ready packages. This hands-on role requires building and validating SDTM/ADaM datasets, TFLs and delivery of analysis outputs with regulatory scrutiny in mind.

You'll lead end-to-end programming, mentor junior staff, review CRO deliverables, and shape study analysis through protocols and SAPs, collaborating with statisticians, data

Qualifications

• Experience programming in pharmaceutical or clinical research settings.
• Strong SAS proficiency with regulatory submission experience.
• Knowledge of CDISC standards for SDTM/ADaM.
• Ability to interpret protocols and SAPs for dataset design.
• Experience collaborating with CROs and vendors on data delivery.

Responsibilities

• Lead end-to-end programming for assigned trials from setup to submission.
• Design and validate SDTM/ADaM datasets, tables, figures and listings.
• Review CRO-delivered deliverables for submission readiness.
• Mentor junior programmers and contribute to process improvements.
• Tackle ad hoc analyses and regulatory query responses as needed.

Skills

SAS programming

CDISC standards

Regulatory submissions

Mentor others

Stakeholder collaboration

Education

BSc in Computer Science, Mathematics, Statistics or related field

Tools

SAS

R

Job description

Senior Clinical Statistical Programmer (Portfolio Development / Biometrics / Programming) The Role CSL is looking for a Senior Programmer to take technical ownership of one or two clinical trials from first line of code to final submission package. This is a hands‑on statistical programming role with real authority attached to it: you'll be the person a study team turns to when the data needs to hold up under regulatory scrutiny, and the person who decides how a dataset gets built, not just who builds it. You'll work alongside statisticians, data managers, medical writers and regulatory colleagues as a peer, not a downstream resource — reading protocols and SAPs early enough to shape how a study's analysis gets structured, then seeing that structure through to submission‑ready SDTM and ADaM datasets, TFLs, and supporting documentation.

Hybrid Based (3 days a week onsite) in Maidenhead

Why It Matters

Clinical data is only as useful as the programming behind it is trustworthy. Every regulatory decision downstream — every safety signal caught or missed, every submission accepted or queried — traces back to whether the datasets and outputs were built right the first time. This role sits at that pressure point. You're not just executing specifications; you're often the one writing them, catching the ambiguity in a protocol before it becomes a data problem three months later, and making the judgment calls that keep a study's analysis both scientifically sound and audit‑ready.

What You'll Be Responsible For

You'll lead end-to-end programming for your assigned studies — in-house or outsourced — spanning the full clinical development lifecycle from study setup through analysis, reporting, and regulatory submission. That means building and validating datasets and outputs yourself where the work is done internally, and holding CRO‑delivered work to the same bar where it isn’t. You'll also be a technical reference point for less experienced programmers, and a contributor to how the wider programming function does its work.

• Serve as lead programmer for one or two clinical trials, interpreting protocols, SAPs, data management plans, and CRF specifications to drive study setup and analysis
• Design and validate SDTM and ADaM datasets, tables, figures, and listings, in partnership with study statisticians
• Review and take ownership of CRO‑produced deliverables, ensuring submission‑ready quality before they go further
• Lead specification and delivery of integrated analyses (e.g. ISS/ISE) and associated outputs when not handled by a CRO
• Mentor other programmers on internal processes and standards, and contribute to departmental tools and process improvements
• Take on ad hoc analytical work — regulatory query responses, exploratory analyses, publication support — as studies require it

Experience Required

• Experience of programming in pharmaceutical, biotech, CRO, or clinical research settings
• Strong SAS proficiency (Base/Macro/Stat/Graph); familiarity with R or other languages is a plus
• Working knowledge of current CDISC standards — CDASH, SDTM, ADaM, define.xml
• Track record of producing and validating submission‑ready TFLs and datasets, including ad‑hoc analytical requests
• Experience supporting regulatory submissions (FDA required; PMDA, NMPA, or EMA experience a plus)
• Comfort working with external vendors and CRO‑managed data
• BSc in Computer Science, Mathematics, Statistics or a related field — equivalent experience and certifications will also be considered

About CSL Seqirus

CSL Seqirus is part of CSL. As one of the largest influenza vaccine providers in the world, CSL Seqirus is a major contributor to the prevention of influenza globally and a transcontinental partner in pandemic preparedness. With state‑of‑the‑art production facilities in the U.S., the U.K. and Australia, CSL Seqirus utilizes egg, cell and adjuvant technologies to offer a broad portfolio of differentiated influenza vaccines in more than 20 countries around the world. To learn more about CSL, CSL Behring, CSL Seqirus and CSL Vifor visit https://www.csl.com/ and CSL Plasma at https://www.cslplasma.com/.

Our Benefits

For more information on CSL benefits visit How CSL Supports Your Well‑being | CSL.

You Belong at CSL

At CSL, Inclusion and Belonging is at the core of our mission and who we are. It fuels our innovation day in and day out. By celebrating our differences and creating a culture of curiosity and empathy, we are able to better understand and connect with our patients and donors, foster strong relationships with our stakeholders, and sustain a diverse workforce that will move our company and industry into the future. To learn more about inclusion and belonging visit https://www.csl.com/careers/inclusion-and-belonging

Equal Opportunity Employer

Equal Opportunity Employer CSL is an Equal Opportunity Employer. If you are an individual with a disability and need a reasonable accommodation for any part of the application process, please visit https://www.csl.com/accessibility-statement. Watchour ‘On the Front Line’ video to learn more about CSL Seqirus CSL is an EqualOpportunity Employer. If you are an individual with a disability and need a reasonable accommodation for any part of the application process, please click here.

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