Scientist - Infectious Diseases - Oxford

IMMUNOCORE LTD; Steeple Claydon; On-site; GBP 42,000 - 65,000; Full time

Job summary

Immunocore in Oxford is seeking a Scientist – Infectious Diseases to advance projects using the ImmTAX platform. You will plan and execute experiments across molecular and cellular assays, including advanced sequencing and flow cytometry, contributing to HIV/HBV/EBV related programs.

You will work in a multi-disciplinary team, present results, and help push drug development from discovery toward clinical exploration, while expanding your expertise in relevant diseases and technologies in line

Qualifications

• PhD in molecular biology, cell biology, genomics, virology, immunology, or related discipline with 0–2 years of experience.
• Alternatively, a BSc or MSc with significant work experience in relevant scientific areas.
• Bench-based laboratory experience with proficiency in Droplet Digital PCR, NextGen sequencing, Genomics/Transcriptomics, PCR, Mutagenesis, qPCR, and culturing primary cells or cell lines.

Responsibilities

• Plan, design and execute assignments to meet project goals within defined timeframes.
• Execute experiments addressing scientific questions using a range of molecular and cellular techniques (e.g., DD-PCR, qPCR, cell culture, flow cytometry, ELISAs, ELISpots).
• Work in a containment level 3 (CL3) facility and handle human viruses as required.
• Analyse data, interpret results, and make recommendations.
• Expand scientific knowledge in HIV/HBV/EBV biology and drug development through literature review and seminars.
• Collaborate in a matrixed team and cross-functional settings; present findings in internal meetings.
• Establish internal or external collaborations to support project progression.

Skills

Molecular biology

Immunology

Virology

Genomics/Transcriptomics

qPCR

Cell culture

Data analysis

Education

PhD in molecular biology / related field

BSc or MSc with significant relevant experience

Tools

Droplet Digital PCR

NextGen sequencing

PCR

Genomics/Transcriptomics

Flow cytometry

ELISAs

ELISpots

Viral integration site analysis

Job description

The primary purpose of this role is to contribute to cross functional efforts focused on applying the ImmTAX platform or other modalities to the development of novel treatments for chronic infections, including HIV and HBV and EBV-associated diseases. The team is involved in multiple stages of the drug discovery and development process, from target discovery all the way to clinical trials. Examples of key preclinical research are published in Yang H et al., Mol Ther. 2016; 24,11; Fergusson J et al., Hepatology 2020; 72,5; Wallace Z et al., Mol Ther 2024; 32, 678. The postholder will plan, design and execute experimental investigations to support the advancement of the Company pipeline, processes and technology capabilities, with guidance from their manager, ensuring that project goals are met within time and budget constraints. They will be expected to demonstrate technical proficiency, rigour in assessing their own data and that of others, scientific creativity and independent thought. This position requires participation and presentation of results at internal meetings, sharing information learned at external scientific meetings and establishing productive relationships with colleagues across Research and other departments.,

• With instruction and guidance from manager - plan, design, and execute assignments to meet project goals within defined timeframes
• Execute experiments to address key scientific questions and enable project progression, utilizing range of molecular and cellular techniques including some of the following: NextGen sequencing, DD-PCR, qPCR, cell culture, flow cytometry, ELISpots, ELISAs,
• Some work will be conducted in a containment level 3 (CL3 facility) and will require handling of human viruses
• Analyse data, interpret results, and make recommendations
• Proactively expand scientific/technical knowledge in relevant fields including HIV/HBV/EBV related disease biology and drug development through review of scientific literature/ conference updates, peer to peer mentoring, and attendance at seminars/conferences in line with company strategy
• Work effectively in a matrixed team structure and as part of cross functional teams
• Participate and present results at internal meetings
• Establish relationships and possible collaborations within and outside of the company

Qualifications

• PhD in molecular biology, cell biology, genomics, virology, immunology, or related discipline and 0-2 years related experience
• Alternatively, a BSc or MSc with significant work experience in relevant scientific areas
• Worked in a bench-based laboratory environment and proficient in the following key techniques:
  • Droplet Digital PCR
  • NextGen sequencing
  • Genomics/Transcriptomics
  • PCR
  • Mutagenesis
  • qPCR
  • Culturing primary cells and/or cell lines

Preferred Qualifications:

• Knowledge/expertise of Immunology/HIV/HBV/EBV
• Flow cytometry, ELISAs, ELISpots
• Viral integration site analysis

Scientist - Infectious Diseases - Oxford Immunocore (NASDAQ: IMCR)

is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry's most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.

Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases. At Immunocore, we recognize that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients' lives, advancing medicine, and supporting one another in these pursuits.