Scientist - Infectious Diseases - Oxford

IMMUNOCORE LTD; Little Missenden; On-site; GBP 40,000 - 65,000; Full time

Job summary

Oxford Immunocore is seeking a Scientist in Infectious Diseases to advance the pipeline using immunology and molecular biology methods in a collaborative, matrixed environment. The role involves planning experiments, data analysis, and presenting results across departments to drive project progression.

The candidate will work with NextGen sequencing, qPCR, flow cytometry, and related technologies, with opportunities to contribute to HIV/HBV/EBV-related programs in a cutting-edge biotech setting.

Qualifications

• PhD in molecular biology, cell biology, genomics, virology, immunology, or related discipline and 0–2 years of related experience.
• Alternatively, a BSc or MSc with significant work experience in relevant scientific areas.
• Experience in bench-based laboratory environment and proficiency in core techniques listed.

Responsibilities

• Plan, design, and execute assignments to meet project goals within defined timeframes.
• Execute experiments to address key scientific questions using molecular and cellular techniques including NextGen sequencing and qPCR.
• Some work in a containment level 3 (CL3) facility and handling of human viruses.
• Analyse data, interpret results, and make recommendations.
• Proactively expand scientific/technical knowledge through literature reviews and seminars.
• Work effectively in a matrixed, cross-functional team and present results at internal meetings.

Skills

NextGen sequencing

Droplet Digital PCR

qPCR

Cell culture

Flow cytometry

ELISpots

ELISAs

PCR

Genomics/Transcriptomics

Mutagenesis

Primary cell culture

Education

PhD in molecular biology / cell biology / genomics / virology / immunology

BSc or MSc with significant relevant experience

Job description

The primary purpose of this role is to contribute to cross functional efforts focused on applying the ImmTAX platform or other modalities to the development of novel treatments for chronic infections, including HIV and HBV and EBV-associated diseases. The team is involved in multiple stages of the drug discovery and development process, from target discovery all the way to clinical trials. Examples of key preclinical research are published in Yang H et al., Mol Ther. 2016; 24,11; Fergusson J et al., Hepatology 2020; 72,5; Wallace Z et al., Mol Ther 2024; 32, 678. The postholder will plan, design and execute experimental investigations to support the advancement of the Company pipeline, processes and technology capabilities, with guidance from their manager, ensuring that project goals are met within time and budget constraints. They will be expected to demonstrate technical proficiency, rigour in assessing their own data and that of others, scientific creativity and independent thought. This position requires participation and presentation of results at internal meetings, sharing information learned at external scientific meetings and establishing productive relationships with colleagues across Research and other departments.,

• With instruction and guidance from manager - plan, design, and execute assignments to meet project goals within defined timeframes
• Execute experiments to address key scientific questions and enable project progression, utilizing range of molecular and cellular techniques including some of the following: NextGen sequencing, DD-PCR, qPCR, cell culture, flow cytometry, ELISpots, ELISAs,
• Some work will be conducted in a containment level 3 (CL3 facility) and will require handling of human viruses
• Analyse data, interpret results, and make recommendations
• Proactively expand scientific/technical knowledge in relevant fields including HIV/HBV/EBV related disease biology and drug development through review of scientific literature/ conference updates, peer to peer mentoring, and attendance at seminars/conferences in line with company strategy
• Work effectively in a matrixed team structure and as part of cross functional teams
• Participate and present results at internal meetings
• Establish relationships and possible collaborations within and outside of the company
  PhD in molecular biology, cell biology, genomics, virology, immunology, or related discipline and 0-2 years related experience
• Alternatively, a BSc or MSc with significant work experience in relevant scientific areas
• Worked in a bench-based laboratory environment and proficient inthe following key techniques:
• o molecular techniques including some of the following: Droplet Digital PCR, NextGen sequencing, Genomics/Transcriptomics, PCR, Mutagenesis, qPCR
• o Culturing primary cells and/or cell lines
• Preferred Qualifications:
• Knowledge/expertise of Immunology/HIV/HBV/EBV
• Flow cytometry, ELISAs, ELISpots
• Viral integration site analysis
• Scientist - Infectious Diseases - Oxford Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry's most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.