Research Associate in Ocular Molecular Biology - (8681)

Manchester Metropolitan University; Manchester; On-site; GBP 30,000 - 45,000; Full time

Job summary

A leading academic institution in Manchester seeks a researcher to join their Molecular Cell Biology team. This role involves investigating retinal pigment epithelium biology in the context of ageing and disease using innovative cell-based models. Candidates should hold a PhD in molecular/cell biology with experience in disease models, cell culture, and data analysis. This position offers opportunities for collaborative research and high-quality publications.

Benefits

Flexible working arrangements

Professional development opportunities

Inclusive culture promoting diversity

Qualifications

• Excellent communication skills and a commitment to high-quality research.
• Experience in investigating models of disease.
• Ability to master existing techniques.

Responsibilities

• Engage positively in research activity under the direction of the principal investigator.
• Complete high-quality research on RPE ageing biology and disease.
• Publish research outputs in leading peer-reviewed journals.

Skills

Cell culture

Molecular biology

Data analysis

CRISPR techniques

Education

PhD in molecular/cell biology

Job description

About the Role

This is an exciting opportunity to join the Molecular Cell Biology and Mechanisms of Disease Group led by Professor Luminita Paraoan, in the Department of Life Sciences at Manchester Metropolitan University. The project focuses on the biology and function of the retinal pigment epithelium (RPE) in health, ageing and disease. It aims to use innovative, advanced in vitro cell-based models to characterise the role of ageing through genetic and pharmacological interventions and to deploy CRISPR screens to interrogate pathways involved in crosstalk between IRD pathogenesis and ageing.

The experimental research will be carried out in fully equipped, modern laboratories with state-of-the-art facilities in the Dalton Building in central Manchester, with opportunities to engage with established national and international collaborations of the group.

About the Project

Inherited retinal dystrophies (IRDs) are a heterogeneous group of degenerative disorders, mostly monogenic, impacting retinal structure and function. They are designated as orphan or rare diseases, affecting a limited portion of the population, such that specific patient cohorts and the body of research and treatment options are limited. Later-onset IRDs tend to be progressive and worsen with age. The biological and clinical implications of ageing on IRD progression, epidemiology, severity, and the molecular mechanisms underpinning pathology have yet to be investigated. With an ageing population and late diagnoses, studying this interaction is significant for developing novel, gene-agnostic therapeutic approaches.

The current project aims to deploy high-throughput CRISPR-Cas9 genomic screening to identify molecular processes at the interface of IRDs and ageing that can be leveraged for gene-agnostic therapies.

About You

To be successful in this role, you will:

• Possess a PhD in molecular/cell biology, with an excellent educational and research record, inquisitive mind and exceptional drive for innovative research.
• Bring excellent communication skills and a strong commitment to high-quality research with experience in investigating models of disease and required skills in cell culture, molecular biology and interpreting complex datasets.
• Apply your research skills to a stimulating and cutting-edge project and be willing to master existing techniques.
• Take initiative and responsibility, under supervision of the principal investigator, in planning research, developing and applying techniques, and obtaining valid experimental data.
• Be responsible for data analysis, records of findings, preparing internal and external presentations of your data and reports for sponsors, contributing to drafting publications and to writing bids for research grants.
• Engage with the national and international collaborations of the group, and promote the reputation of the laboratory, Faculty and wider University.
• Previous experience in CRISPR/expression screens is highly desirable.

Duties and Responsibilities

The post holder will be expected to:

• Engage positively in research activity in the broad area of Molecular Cell Biology of Ageing under the direction of the principal investigator, working independently and with collaborators.
• Complete high-quality research in the area of RPE ageing biology and disease, leading elements of the project, including data acquisition and analysis, accurate records, presenting data, reports for sponsors, drafting publications for refereed journals and contributing to grant proposals.
• Publish research outputs in leading peer-reviewed journals with an international audience, as lead author where appropriate.
• Engage with relevant academic and professional networks through active membership of societies and associations.
• Contribute to development of applications for research funding from research councils and other external sources in collaboration with the project lead and others.
• Ensure skills and technical competence are kept under review and enhanced to utilise specialist equipment and software used in the research projects.

To Apply

• To apply, please submit a CV and covering letter detailing your suitability for the role.
• For an informal discussion, please contact Professor Luminita Paraoan at [e-mail]

We believe in working together, sharing knowledge and valuing everyone's contributions. Develop your skills, further your knowledge and be part of a team transforming lives every day.

Manchester Metropolitan University fosters an inclusive culture of belonging that promotes equity and celebrates diversity. We value a diverse workforce and welcome applications from local and international communities, including those from Black, Asian, and Minority Ethnic backgrounds, disabled people, and LGBTQ+ individuals.

We support flexible working arrangements, including hybrid and tailored schedules, which can be discussed with your line manager. If you require reasonable adjustments during recruitment or in your role, please let us know so we can provide appropriate support. Our commitment to inclusivity includes mentoring programmes, accessibility resources and professional development opportunities to empower and support underrepresented groups.

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