Proteomics Scientist

The John Innes Centre; Norwich; On-site; GBP 37,000 - 46,000; Full time

Job summary

A leading research institute in Norwich is seeking a Proteomics Specialist to support various proteomics projects. This full-time role involves operating advanced mass spectrometers, preparing samples for analysis, and providing data support to researchers. A PhD in a relevant field or equivalent experience is essential, alongside expertise in proteomics techniques and excellent communication skills. The position offers a competitive salary and an inclusive working environment.

Qualifications

• Experience in proteomics-based work with substantial hands-on application.
• Proficient in preparation of high-quality samples for advanced experiments.
• Prior experience of running quantitative MS experiments.

Responsibilities

• Provide proteomics support to research groups.
• Operate and maintain advanced mass spectrometers.
• Prepare samples for proteomics analysis.

Skills

Expertise in running and analysing proteomics experiments

Proficiency in quantitative proteomics methods

Knowledge in protein separation and enrichment sciences

Excellent communication skills

Time management and organisational skills

Education

PhD in relevant subject

MSc/BSc or equivalent in biological sciences

Tools

Mass spectrometry data analysis software

Thermo Orbitrap Eclipse

Bruker MALDI-TOF

Waters Synapt Q-TOF

Job description

Hours per week 37
Project Title The role will be based in the JIC Proteomics Platform. This position is for a Proteomics Specialist, who will help serve the growing needs of proteomics-based technology at the John Innes Centre (JIC).
Months Duration Indefinite

Job Description

The Proteomics Scientist will work within the Proteomics Platform at JIC to provide proteomics support to a diverse array of researchers. The role will span multiple aspects of complex proteomics experiments, including advising on experimental design, instrument maintenance and operation, method optimisation, data analysis pipelines, interactions with users/clients, training, sample preparation, data processing, presentation of data, and contributions to associated manuscripts.

Main Purpose of the Job

Provide comprehensive proteomics support to research groups across the Institute and external partners through instrument operation, sample preparation, method development, data analysis, training and publication contributions.

Key Relationships

• Internal: Line manager, proteomics platform manager and, as necessary, other researchers, research support staff and students across the Institute.
• External: TSL proteomics team associated with equipment sharing; other clients and collaborators from external institutions; engineers and support specialists associated with proteomics equipment.

Main Activities & Responsibilities

• Percentage 20 – Operate and maintain several advanced mass spectrometers including the requisite software and nano-scale liquid chromatography systems.
• Percentage 20 – Prepare samples for proteomics analysis including protein quantification, enzymatic digestion, isobaric labelling, sample clean up.
• Percentage 20 – Run samples on a nanoLC-MS system with an Orbitrap Eclipse mass spec for proteomics analysis.
• Percentage 20 – Process mass spec raw data for peptide/protein identification and quantification.
• Percentage 10 – Support proteomics projects through employing efficient and accurate data evaluation techniques, placing levels of statistical confidence on data output, and clearly reporting results.
• Percentage 10 – Interact with faculty and staff and present technical data through presentations and report writing.
• Percentage 5 – Train others on procedures, operations and new technology, or methods.
• Percentage 5 – Ensure research and record keeping is carried out in accordance with good practice, Scientific Integrity and in compliance with local policies and any legal requirements.
• Percentage 5 – Contribute methods, data and analysis to associated research publications.
• Percentage 5 – As agreed with line manager, any other duties commensurate with the nature of the role.

Education & Qualifications

• Essential – PhD or other research role with significant proteomics experience.
• Essential – MSc/BSc or equivalent in biological sciences.

Specialist Knowledge & Skills

• Essential – Expertise in running and analysing proteomics experiments.
• Essential – Proficiency in quantitative proteomics methods, such as isobaric labelling.
• Essential – Proficiency with common mass spectrometry proteomics data analysis software.
• Essential – Knowledge in protein separation and enrichment sciences.
• Essential – Knowledge and interest in biological protein structure, function and interaction.
• Essential – Proficiency in data dependent and data independent acquisition modes.
• Desirable – Experience of oral research presentations and written presentations.
• Desirable – Experience of supervising, training and mentoring visitors and students.
• Desirable – Preparing data / information for grant proposals.
• Desirable – Experience in working with different types of mass spectrometers including Orbitrap and MALDI-TOF.
• Desirable – Experience with mass spectrometry imaging.

Interpersonal & Communication Skills

• Essential – Excellent communication skills, both written and oral, including the ability to present complex information with clarity.
• Essential – Good interpersonal skills, with the ability to work as part of a team.
• Essential – Demonstrated ability to work independently, using initiative and applying problem solving skills.
• Essential – Excellent time management and organisational skills.
• Essential – Ability to collaborate with internal and external stakeholders.
• Essential – Ability to follow instructions/Standard Operating Procedures.
• Essential – Promotes and strives for continuous improvement.

Additional Requirements

• Essential – Promotes equality and values diversity.
• Essential – Willingness to embrace the expected values and behaviours of all staff at the Institute, ensuring it is a great place to work.
• Essential – Able to present a positive image of self and the Institute, promoting both the international reputation and public engagement aims of the Institute.
• Essential – Ability to maintain confidentiality and security of information where appropriate.
• Essential – Willingness to work outside standard working hours when required.
• Essential – Ability to undertake occasional travel (national and international) related to collaborations and/or seminars.
• Essential – Attention to detail.

Who We Are

The John Innes Centre is an independent, international centre of excellence in plant and microbial genetics, carrying out fundamental and strategic research, training scientists and making our findings available to society.

Our research makes use of a wide range of disciplines in the biological and chemical sciences including: cell biology, biochemistry, chemistry, genetics and molecular biology.

We pride ourselves on being a welcoming and inclusive working environment for all. We have a diverse and multicultural scientific community and thrive on our European and international links, appointing staff from across the world.

For further information on current or anticipated immigration requirements contact the HR Team on [phone] or [e-mail].

We are proud to hold a prestigious Athena SWAN Gold award, recognising the impact of our work in promoting gender equality in science. We are also a proud member of the Stonewall Diversity Champion’s programme and, as a Disability Confident employer, guarantee to offer an interview to all disabled applicants who meet the essential criteria for the post.

The John Innes Centre is a registered charity (No. 223852), limited by guarantee (registered in England No. 511709).

Department

Biochemistry and Metabolism

Researchers within the Department of Biochemistry and Metabolism investigate the structure and function of biological macromolecules and fundamental aspects of plant and microbial metabolism. They aim to understand the mechanisms underpinning metabolic diversity and how to manipulate proteins, carbohydrates, small molecules and DNA, research which is facilitating advances of agricultural, environmental, medical and industrial importance.

Proteomics Scientist

Salary: £37,500 - £45,350 per annum depending on qualifications and experience.

Contract: Indefinite, full-time.

Location: John Innes Centre, Norwich, UK.

Closing date: 9 November 2025

Reference: 1004976

The role:

Applications are invited for an enthusiastic and talented proteomics specialist to join our Proteomics Platform in a full‑time, indefinite post. The specialist will work alongside an experienced platform manager to support proteomics projects, including instrument maintenance and operation, sample preparation, method optimisation, data analysis pipelines, interactions with users/clients, advising on experimental design, and training. The specialist will also assist with data processing and contribute to associated research papers.

While the work is focused on proteomics on the Orbitrap Eclipse, the role will also involve the operation and maintenance of several advanced mass spectrometers (Thermo Orbitrap Eclipse, Bruker MALDI-TOF, Waters Synapt Q-TOF) including the requisite software and nano‑scale liquid chromatography systems.

The candidate will have substantial experience in proteomics‑based work and a PhD in a relevant subject, or equivalent research experience in proteomics. Hands‑on experience in the application of mass spectrometry/LC‑MS techniques to the detailed characterization of proteins is essential for this role. Prior experience of running quantitative MS experiments is essential.

The candidate should be skilled in the preparation of high‑quality samples for advanced experiments, such as protein quantification and isobaric labelling. Proficiency with common mass spectrometry proteomics data analysis software is desirable. Experience in working with different types of mass spectrometers, such as mass‑spec imaging (MALDI‑imaging), is desirable.

This role meets the criteria for a visa application, and we encourage all qualified candidates to apply. For visa questions contact the Human Resources Team.

We are an equal opportunities employer, actively supporting inclusivity and diversity. As a Disability Confident organisation we guarantee to offer an interview to all disabled applicants who meet the essential criteria. We hold a prestigious Gold Athena SWAN award and are a member of Stonewall’s Diversity Champions programme. The Institute offers a family‑friendly workplace and a stimulating research environment.