Principal Statistical Programmer

JR United Kingdom; Woking; On-site; GBP 60,000 - 80,000; Full time

Job summary

A leading clinical research organization is seeking a Principal Statistical Programmer to oversee statistical programming projects remotely from anywhere in the UK. The ideal candidate will have extensive experience in clinical trial programming and a deep understanding of statistical methodologies. This role provides a flexible work environment and the chance to collaborate in a dynamic team, ensuring high-quality deliverables that comply with regulatory standards.

Benefits

Healthy work-life balance

Flexible hours

Fully remote

Qualifications

• 8 years of experience in clinical trial statistical programming.
• Excellent knowledge of SAS essential with R advantageous.
• Understanding of clinical data standards, TLFs, and submission guidelines.

Responsibilities

• Lead statistical programming projects, ensuring high-quality, on-time deliverables.
• Develop and validate SDTM and ADaM datasets.
• Resolve Pinnacle 21 validation issues and review TLFs for consistency.

Skills

SAS

Statistical programming

Data structures knowledge (CDISC, SDTM, ADaM)

R programming

Education

Bachelor’s degree in Statistics, Biostatistics, or Computer Sciences

Masters or PH.D in Statistics

Job description

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Principal Statistical Programmer, working

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Client:

Warman O'Brien

Location:

Woking, United Kingdom

Job Category:

Other

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EU work permit required:

Yes

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Job Views:

3

Posted:

26.08.2025

Expiry Date:

10.10.2025

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Job Description:

Principal Statistical Programmer | Leading CRO | Home Based | UK |

Join a fast-growing, independent CRO providing a broad range of expertise-based clinical research services to worldwide pharmaceutical, biotechnology, and medical device industries.

Renowned for its high-quality deliverables, exceptional customer service, and flexibility in meeting clients’ needs, this growing organisation offers a flexible, dynamic, and entrepreneurial culture. With ongoing growth and exciting career opportunities, it’s the perfect place to advance your career.

We’re seeking elite Principal Statistical Programmers to join this growing organisation remotely from anywhere in the UK.

What you will be doing:

You’ll lead statistical programming projects, ensuring high-quality, on-time deliverables. This includes developing and validating SDTM and ADaM datasets, performing QC reviews, and ensuring CDISC compliance.

You’ll resolve Pinnacle 21 validation issues, review TLFs for consistency, and contribute to regulatory submissions. You'll also create define.xml files, develop and maintain macros, and perform data integrity checks, while ensuring proper documentation and compliance with SOPs.

What you will need:

• A Bachelor’s degree in Statistics, Biostatistics or Computer Sciences + Masters or PH.D in Statistics.
• 8 years’ experience in clinical trial statistical programming.
• Excellent knowledge of SAS essential with R advantageous.
• Good working knowledge of data structures e.g. CDISC, SDTM, ADaM,
• Understanding of clinical data standards (CDISC), TLFs, and submission guidelines.

What in it for you:

• The opportunity to be involved in a growing organisation.
• Enjoy a healthy work-life balance with flexible hours that fit your lifestyle.
• Fully remote in the UK.

What to do next:

• If this opportunity interests you, please apply now with your CV as the organisation is looking to arrange interviews for Principal Statistical Programmers as soon as possible.

Not what you’re looking for?

• Please contact Jo Fornaciari on [phone] for a confidential discussion about potential opportunities.