Principal Biostatistician (UK/Europe)

Worldwide Clinical Trials; Nottingham; Remote; GBP 85,000 - 110,000; Full time

Job summary

Worldwide Clinical Trials is seeking a Principal Biostatistician to lead statistical strategy across multi-project portfolios. You will design, analyse, and interpret clinical data, guiding study strategies and ensuring high-quality outputs in collaboration with sponsors and cross-functional teams.

You will mentor colleagues, oversee SAS programming and SDTM/ADaM workstreams, and contribute to process improvements and regulatory readiness across diverse trials.

Qualifications

• Lead or project biostatistician with statistical leadership across studies.
• Strong knowledge of clinical trial design, analysis and regulatory standards.
• Advanced SAS programming and integrity in reporting outputs.

Responsibilities

• Lead statistical strategy, design, analysis, and reporting across projects.
• Develop and review SAPs, protocols, randomisation, and statistical deliverables.
• Provide expert statistical consultation to sponsors and teams.
• Oversee SAS programs and SDTM/ADaM datasets creation and validation.
• Deliver tables, figures, listings, and ad hoc analyses to support objectives.
• Mentor biostatisticians in study design and methodology.
• Contribute to quality initiatives and inspection-readiness activities.

Skills

Lead biostatistician

Statistical leadership

SAS programming

Communication skills

English proficiency

Education

BSc with 8+ years

MSc with 6+ years

PhD with 4+ years

Tools

SAS programming

SDTM/ADaM datasets

Job description

Join a global Contract Resource Organization (CRO) where innovation meets purpose. At Worldwide Clinical Trials, we're driven by a shared commitment to improving lives through high-quality clinical research. Our teams are empowered to think creatively, take ownership, and deliver meaningful work that helps bring life-changing therapies to patients around the world.

With more than 4,000 professionals across the globe, we foster a collaborative and inclusive environment where diverse perspectives are valued, growth is encouraged, and every contribution makes an impact. Whether you're building your career or bringing years of experience, you'll have the opportunity to learn, grow, and help shape the future of clinical research.

Make an Impact as a Principal Biostatistician at Worldwide

As a Principal Biostatistician, you will play a leading role in the design, analysis, and interpretation of clinical trial data that supports the development of new medicines and therapies. Your statistical expertise will help shape study strategies, inform critical decisions, and ensure the delivery of high-quality scientific outputs.

Working across a diverse portfolio of clinical research projects, you will provide statistical leadership from study design through reporting, partnering with sponsors, cross-functional teams, and external stakeholders. You will serve as a trusted consultant, helping to drive scientific excellence, regulatory compliance, and efficient study delivery.

This is an opportunity to combine hands‑on technical expertise with project leadership, influencing clinical development programmes while mentoring colleagues and contributing to the advancement of statistical methodologies and best practices.

Where You'll Work

This is a remote role open to candidates based in UK, Europe. You will collaborate with global teams across multiple time zones.

What You'll Do

• Lead statistical strategy, design, analysis, and reporting activities across one or more clinical research projects or sponsor programmes.
• Develop and review Statistical Analysis Plans, study protocols, randomisation methodologies, and other key statistical deliverables.
• Provide expert statistical consultation to sponsors, project teams, and external stakeholders throughout the clinical trial lifecycle.
• Oversee the development, validation, and review of SAS programs, derived datasets, SDTM/ADaM datasets, and statistical outputs.
• Deliver high-quality tables, figures, listings, reports, and ad hoc analyses to support study objectives and decision‑making.
• Collaborate with cross‑functional teams, sponsors, vendors, and regulatory stakeholders to address statistical and reporting requirements.
• Mentor and guide biostatisticians on study design, analytical approaches, and statistical methodology.
• Contribute to process improvements, quality initiatives, policy development, and inspection‑readiness activities to enhance efficiency and data quality.
• Represent the biostatistics function in sponsor meetings, external forums, and scientific discussions, keeping abreast of evolving statistical and regulatory developments.

What You'll Bring

• BSc with at least 8 years' relevant experience, MSc with at least 6 years' relevant experience, or PhD with at least 4 years' relevant experience in biostatistics or a related field.
• Demonstrated experience as a lead or project biostatistician, providing statistical leadership across clinical research studies.
• Broad experience applying statistical methods across multiple phases of clinical development and across a variety of therapeutic areas.
• Strong knowledge of clinical trial design, statistical analysis, regulatory standards, and interactions within regulated research environments.
• Advanced SAS programming expertise, including experience with SDTM, ADaM, derived datasets, and statistical reporting outputs.
• Excellent project planning, prioritisation, and time‑management skills, with the ability to manage multiple studies simultaneously.
• Strong communication, consulting, influencing, and relationship‑building skills, with experience collaborating across multidisciplinary teams and external stakeholders.
• Proficiency in English, with strong written and verbal communication skills.

Discover the Difference

We love knowing that someone is going to have a better life because of the work we do. Discover the Difference at Worldwide Clinical Trials. Explore additional opportunities on our careers page, visit http://www.worldwide.com/careers, or connect with us on LinkedIn.