Postdoctoral Research Associate in Natural Product Chemistry

University of Oxford; Oxford; Presencial; GBP 39 000 - 44 000; Tempo integral

Resumo da oferta

The University of Oxford, within the Oxford Martin Programme on Safer Antifungals, seeks a researcher to lead a biochemical project on naturally inspired antifungal compounds derived from bdelloid rotifers. You will work with an interdisciplinary team spanning Biology, Pharmacology, Chemistry, and Medicine, translating discoveries into a platform for safer antifungal agents.

The successful candidate will hold a PhD in a relevant field, with experience in chemical purification, structure

Qualificações

• Strong research expertise in chemistry/biochemistry or related chemical biology field.
• Experience purifying chemicals from complex biological mixtures and elucidating structures.
• Knowledge of biosynthetic pathways and natural product synthesis is desirable.

Responsabilidades

• Lead a biochemical research project on natural antifungal compounds.
• Conduct bioactivity-guided extraction and purification.
• Elucidate structure and mechanism of action of hit compounds.
• Investigate biosynthetic origins and pathways; diversify compounds.
• Perform assays for biological activity and toxicity; report results.

Conhecimentos

Chemistry

Biochemistry

Biosynthetic chemistry

Chemical biology

Formação académica

PhD in a relevant discipline

Descrição da oferta de emprego

Location

Life and Mind Building, South Parks Road and Department of Pharmacology, Mansfield Road, Oxford

About the role

The Oxford Martin Programme on Safer Antifungals aims to unlock a new generation of naturally inspired products to combat fungal diseases in agriculture and medicine. You will lead a biochemical research project exploiting a novel source of natural antifungal products. The work centres on microscopic freshwater animals called bdelloid rotifers, which naturally protect themselves from fungi using genes acquired through horizontal DNA transfer. You will join an interdisciplinary team translating this recent discovery into a platform for identifying safer antifungal compounds bringing together expertise from Biology, Pharmacology, Chemistry, Medicine, the Ineos Oxford Institute and Oxford University Innovation. Your work will include bioactivity-guided extraction and purification of antifungal compounds, elucidation of their structure and mechanism of action, investigation of biosynthetic origins and candidate pathways, chemical or biosynthetic diversification of hit compounds, performing assays for biological activity and toxicity, and writing up and communicating results in scientific publications and for future research translation.

About you

The successful applicant will have strong research expertise and specialist knowledge in chemistry, biochemistry, biosynthetic chemistry or related area of chemical biology, including a PhD in a relevant discipline. They will have prior relevant laboratory experience in one or more of the following areas: purifying chemicals from complex biological mixtures; elucidation of chemical structures for biologically active molecules; or genetic and synthetic-biology approaches to natural product synthesis, including biosynthetic pathway elucidation and reconstruction of bioactive molecules. They will show initiative in developing research ideas and methodologies, have excellent written and verbal communication skills, and work effectively as part of a multidisciplinary team and in advising and supervising other team members. Strong interest or experience in research translation and innovation is also desirable.

The University of Oxford is committed to equal opportunity, and to being a place where everyone belongs and is supported to succeed. We recognise how the diversity of our community enriches our ability to deliver on our academic mission. We welcome applications from individuals from all backgrounds, including those under‑represented within higher education. No applicant or members of staff shall be unlawfully discriminated against on the basis of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation.

This post is full time (although applications to work >50% of full time are welcome) and available from 1 January 2027 for 36 months (or until 31 December 2029). The closing date for applications is 12.00 noon on Wednesday 11 November 2026, interviews are likely to be scheduled for mid-November 2026.

£39,424 to £43,984 per annum - Grade 7