Postdoctoral Fellow - H Yardimci Lab

The Francis Crick Institute; City Of London; On-site; GBP 45,000 - 55,000; Full time

Job summary

A leading biomedical research institute in the UK is seeking a Postdoctoral Fellow to contribute to groundbreaking research in DNA replication dynamics. The role involves designing experiments, analysing data, and mentoring junior researchers. Ideal candidates have a PhD in biochemistry or related fields and experience in protein biochemistry. Competitive salary starts at £45,500 with benefits.

Benefits

Generous annual leave

Pension scheme with up to 16% employer contribution

Health and well-being programs

Discounted gym memberships

Subsidised on-site restaurant

Qualifications

• Track record of writing papers evidenced by publications or submitted manuscripts.
• Experience working with nucleic acid processing enzymes or single-molecule methods.

Responsibilities

• Design and execute experiments including single-molecule and biochemical assays.
• Analyse data and report findings in meetings and seminars.
• Assist and train junior members in laboratory techniques.

Skills

Protein biochemistry

Data presentation

Interest in genome maintenance

Education

PhD or in final stages of PhD submission

Tools

TIRF microscopy

Job description

Salary for this Role

From £45,500 with benefits, subject to skills and experience

Job Title

Postdoctoral Fellow – H Yardimci lab

Reports to

Hasan Yardimci

Closing Date

24/Dec/2025 23.59 GMT

Job Description

Job Title: Postdoctoral Fellow – H Yardimci lab

Details of the role:

Reporting to: Hasan Yardimci, Senior Group Leader

Contact term: This is a full-time, fixed term 4 years position on Crick terms and conditions of employment.

Salary: From £45,500 with benefits, subject to skills and experience

Closing date and time: 24th of December 2025 at 11.59pm

About us

The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world‑class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.

The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state‑of‑the‑art infrastructure, cutting‑edge facilities, and a creative and curious culture. We’ve removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high‑quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.

About the role

We are looking for an energetic and research driven Postdoctoral Fellow with a clear vision for scientific impact to join the H Yardimci lab.

The H Yardimci lab specialises in investigating processes involved in eukaryotic DNA replication and genome maintenance using conventional biochemistry and single‑molecule visualisation tools. The group currently consists of around 6 researchers including PhD students, postdoctoral fellows and laboratory research scientists. For more information, please see the laboratory website.

The Project

As a Postdoctoral Fellow, you will contribute to a cutting edge project investigating the fundamental mechanisms of eukaryotic DNA replication. The research aims to unravel how the DNA replication machinery responds to replication stress and safeguards genome stability.

You will play a key role in shaping the scientific direction of the project by critically evaluating the literature, identifying open questions in replication stress, and proposing innovative experimental approaches to address them. You will also take the lead on writing manuscripts, contributing to grant reports, and documenting protocols.

What you will be doing

• Designing experiments including planning and executing cutting‑edge single‑molecule and biochemical assays to investigate DNA replication dynamics under stress.
• Carry out experimental protocols including preparation and manipulation of Xenopus egg extracts for replication assays, protein purification and labelling, single‑molecule and ensemble DNA replication assays.
• Analysing data
• Reporting findings and present results in regular meetings with the PI, at internal groups and institute‑wide seminars
• Assisting more junior members of the lab, training PhD and master’s students in single‑molecule techniques, biochemical approaches, microscopy workflows, and egg‑extract handling

Click here to read more about the lab

Please see the full job description here.

Informal enquiries are welcome, and should be directed to Hasan Yardimci [e-mail].

About you

You will have:

• PhD (including but not limited biochemistry and biophysics) or in the final stages of PhD submission*
• Experience in protein biochemistry*
• Track record of writing papers as evidenced by publications or submitted manuscripts in refereed journals*
• Strong interest in genome maintenance
• Evidence of data presentation at scientific meetings
• Experience in working with nucleic acid processing enzymes or single‑molecule methods including TIRF microscopy (Desirable)

*Minimum requirements

About Working at the Crick

Our values

Everyone who works at the Crick has a valuable role to play in advancing the Crick’s mission and shaping our culture.

• We are bold. We make space for creative, dynamic and imaginative ideas and approaches. We’re not afraid to do things differently.
• We are open. We’re highly collaborative and interactive, and make sure our activities are visible to the outside world.
• We are collegial. We show respect for one another, work cooperatively and support the wider community.

At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We are a Disability Confident: Committed employer and want to ensure that everyone can apply and be part of our recruitment processes and so we’ll make reasonable adjustments if you need them - just let us know when you apply. If you need assistance with applying (i.e., would like to apply by phone or post) please email: [e-mail]

Find out more about life at the Crick.

What will you receive?

At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well‑being and development:

• Visas: Applicants for this role will be eligible for sponsorship to work in the UK

• Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays.

• Pension Scheme: Defined contribution pension with employer contributions of up to 16%.

• Health & Well‑being:
• 24/7 GP consultation services.
• Occupational health services and mental health support programs.
• Eye care vouchers and discounted healthcare plans.

• Work-Life Balance:
• Back‑up care for dependents.
• Childcare support allowance.
• Annual leave purchase options.
• Crick Networks offering diverse groups’ support, community and inclusive social events.

• Perks:
• Discounted gym memberships, bike‑to‑work scheme, and shopping discounts.
• Subsidised on‑site restaurant and social spaces for team interaction.

Please note you must meet the essential criteria listed within the Role Profile, to have your application reviewed. We reserve the right to withdraw this advert at any given time due to the number of applications received.