PhD Studentship: Cracking the Chain of Command in Multidrug Efflux Evolution

University of East Anglia; Norwich; On-site; GBP 20,000 - 24,000; Full time

Benefits offered by this job

Tuition fees paid

Stipend £21,805 per year

Research Training Support Grant £5,000

Job summary

The Quadram Institute Bioscience and University of East Anglia are offering a four-year Biosciences Doctoral Training Partnership PhD based at the Quadram Institute on the Norwich Research Park. You will work with Professor Mark Webber and Dr Gemma Langridge on a cutting-edge project investigating how bacteria evolve multidrug resistance.

You will map fitness effects across diverse conditions using a massive transposon library and gain expert training in microbial evolution, genetics, transposon

Responsibilities

• Carry out research on multidrug efflux systems in E. coli and other bacteria.
• Gain training in microbial evolution, genetics, transposon mutagenesis, and bioinformatics.

Job description

Are you passionate about understanding antibiotic resistance at the molecular level? Join Professor Mark Webber and Dr Gemma Langridge at the Quadram Institute Bioscience for a cutting-edge PhD project exploring how bacteria evolve multidrug resistance.

Bacteria carry multiple efflux pumps, yet only a few dominate resistance in clinical isolates. Why this is the case is unclear. This project will investigate the hierarchy of multidrug efflux systems in E. coli and beyond, testing whether this hierarchy is condition‑dependent and alterable.

Using a massive transposon library of 800,000+ mutants, you'll map fitness impacts across diverse conditions—anaerobic growth, biofilms, serum, and more. You'll explore how pump removal reshapes resistance hierarchies and separate functional from regulatory costs.

You’ll gain expert training in microbial evolution, genetics, transposon mutagenesis, and bioinformatics. You will be based within the state‑of‑the‑art Quadram Institute building located on the Norwich Research Park, which host the Centre for Microbial Interactions, a vibrant research community of over 100 microbiology research groups. The project offers a wide range of opportunities for training and personal development in a world class environment.

This project is awarded with a 4‑year Norwich Research Park Biosciences Doctoral Training Partnership PhD DTP studentship. The studentship includes payment of tuition fees (directly to the University), a stipend to cover living expenses (2026/27 stipend rate: £21,805, and a Research Training Support Grant of £5,000pa for each year of the studentship.