PhD: Designer Peptides to Decode Immune Regulation

Instruct-ERIC; Newcastle upon Tyne; Hybrid; GBP 17,000 - 21,000; Full time

Job summary

Instruct-ERIC invites applications for a PhD project hosted at Newcastle University, exploring how bicyclic peptides regulate the immune complement system, with focus on C5 interactions and data-driven peptide design.

Through collaboration with industry and academic partners, the student will gain training in cryo-EM, biophysical assays and computational analysis to model molecular interactions and inform immune regulation research.

Qualifications

• PhD in biology/biochemistry or related field.
• Experience with cryo-EM and biophysical methods is advantageous.
• Ability to integrate experimental data with computational approaches.

Responsibilities

• Visualize peptide interactions with C5 at atomic level using cryo-EM.
• Measure protein–protein interactions with biophysical techniques.
• Investigate cellular consequences of targeting C5 in cells.
• Combine experimental results with machine learning to guide peptide design.

Skills

Cryo-EM

Biophysical techniques

Machine learning

Peptide design

Education

PhD in biology/biochemistry/related

Tools

Cryo-EM

Biophysical assays

Data analysis

Job description

Instruct-ERIC invites applications for a PhD project hosted at Newcastle University, exploring how bicyclic peptides regulate the immune complement system, with focus on C5 interactions and data-driven peptide design.

Through collaboration with industry and academic partners, the student will gain training in cryo-EM, biophysical assays and computational analysis to model molecular interactions and inform immune regulation research.