Director I, Lipid Nanoparticles

AbbVie; Worcester; On-site; GBP 60,000 - 80,000; Full time

Job summary

A leading biopharmaceutical company is seeking a motivated individual to lead LNP delivery efforts. The role involves overseeing a talented team of scientists to drive the development of mRNA/LNP candidates. Candidates should possess a PhD and extensive experience in lipid nanoparticle systems, showcasing leadership in a collaborative environment. This position offers a competitive compensation package along with a comprehensive benefits plan, emphasizing AbbVie’s commitment to innovation and team success.

Benefits

Paid time off

Medical/dental/vision insurance

401(k) plan

Short-term incentive programs

Long-term incentive programs

Qualifications

• 10 years postdoc/industry experience focusing on lipid nanoparticle systems for mRNA delivery.
• Strong ability to work collaboratively across teams.
• Previous experience in targeted LNP for extra hepatic delivery is highly preferred.

Responsibilities

• Lead an internal team of experienced scientists in mRNA and targeted LNP design.
• Define and implement strategies for novel LNP formulations.
• Mentor and coach staff to achieve strategic priorities.

Skills

Lipid chemistry

Formulation development

Analytical techniques

Conjugation chemistry

Communication skills

Team leadership

Education

PhD in biochemistry, chemical engineering, material science or related field

Job description

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

Job Description

Purpose:

We are seeking a highly motivated and collaborative individual with deep expertise in the LNP field to lead our non-viral delivery efforts. This person will report to the Sr Director, Head of Genetic Medicine, and join the Genetic Medicine leadership team. The successful candidate will lead a group of approximately 10 Scientists and be responsible for delivering a pipeline of mRNA/LNP development candidates in close collaboration with biotherapeutics, bioconjugation, protein science, therapeutic area and development teams.

Responsibilities

• Lead an internal team of experienced scientists and oversee the design, optimization and production of mRNA and targeted LNP to support in vitro and in vivo studies.
• Define and implement strategies to develop novel LNP formulations and advance targeted LNP delivery by leveraging internal expertise in lipid chemistry, antibody engineering and bioconjugation for in situ mRNA delivery.
• Establish and drive productive collaborations with internal multi-disciplinary project teams and external partners to achieve key milestones.
• Stay up to date on latest development in LNP and other non-viral delivery technologies.
• Dive deeply into science and present scientific findings internally and externally.
• Mentor and coach staff to ensure the team achieve strategic priorities.

Qualifications

• PhD in biochemistry, chemical engineering, material science or related field.
• 10 years postdoc/industry experience focusing on lipid nanoparticle systems for mRNA delivery.
• Strong experience in lipid chemistry, formulation development and analytical techniques.
• Deep understanding of conjugation chemistry.
• Experience in mRNA/LNP scale up production and process development.
• Demonstrated ability to lead a high performing team working in a fast-paced environment.
• Proven ability to work collaboratively across teams to meet project deliverables and timelines.
• Strong communication and decision making skills.
• Previous experience in targeted LNP for extra hepatic delivery is highly preferred.

Prior experience in leading or co-leading a portfolio project to the stage of candidate selection is highly preferred.

Additional Information

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our short-term incentive programs.
• This job is eligible to participate in our long-term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

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