Director, Epidemiology & Evidence Strategy

Barrington James Limited; Greater London; On-site; GBP 140,000 - 190,000; Full time

Job summary

Barrington James Limited is partnering with a large global pharmaceutical organisation to appoint a Director of Epidemiology & Evidence Strategy. This senior role leads epidemiological input across a confidential portfolio of late-stage assets and shapes the evidence strategy for regulatory submissions, lifecycle planning and risk management.

You will build and guide a high-caliber epidemiology team, drive study design and regulatory content, and influence cross-functional partners across

Qualifications

• PhD in Epidemiology (or closely related discipline) required.
• Extensive 12+ years in epidemiology within pharma/biotech or public health, including senior/leadership experience.
• Deep expertise in observational study design, causal inference, and pharmacoepidemiological methods.
• Demonstrated experience authoring epidemiological content for regulatory submissions and interacting with health authorities.
• Track record of leading and developing epidemiology teams.
• Strong scientific writing and publication record.
• Excellent stakeholder management skills, with experience presenting to senior governance and regulatory bodies.

Responsibilities

• Set the overarching epidemiology strategy across the portfolio, aligning with regulatory, clinical, and commercial objectives.
• Serve as the senior scientific authority on disease burden, natural history, and background incidence/prevalence for priority indications.
• Represent epidemiology at senior governance forums, advising on programme-level risk and evidence gaps.
• Build and lead a team of epidemiologists, mentoring junior staff and setting scientific standards across studies.

Skills

PhD in Epidemiology

Leadership

Observational study design

Causal inference

Regulatory submissions

Scientific writing

Stakeholder management

Education

PhD in Epidemiology

Job description

Director, Epidemiology & Evidence Strategy

52731 | Posted: 11/08/2026

• Europe, United States
• Permanent

Permanent | Global Pharmaceutical Company

Overview

We are partnering with a large, global pharmaceutical organisation to appoint a Director, Epidemiology & Evidence Strategy to lead epidemiological input across a confidential portfolio of late-stage assets. This is a senior scientific leadership role, responsible for shaping the epidemiological evidence strategy that underpins regulatory submissions, risk management, and lifecycle planning across multiple indications.

Key Responsibilities

1. Epidemiological Strategy & Leadership

• Set the overarching epidemiology strategy across the portfolio, aligning with regulatory, clinical, and commercial objectives
• Serve as the senior scientific authority on disease burden, natural history, and background incidence/prevalence for priority indications
• Represent epidemiology at senior governance forums, advising on programme-level risk and evidence gaps
• Build and lead a team of epidemiologists, mentoring junior staff and setting scientific standards across studies

2. Study Design & Evidence Generation

• Design and oversee observational studies, including natural history studies, disease registries, and post-authorisation safety/efficacy studies
• Provide expert methodological oversight on epidemiological approaches, including bias mitigation, confounding control, and causal inference frameworks
• Lead development of study protocols, statistical analysis plans, and epidemiological sections of regulatory submissions
• Ensure epidemiological rigor across all evidence-generation activities, from concept through to publication

3. Regulatory & Cross-Functional Engagement

• Author and review epidemiological content for regulatory submissions, risk management plans, and health authority responses
• Act as the epidemiology lead in interactions with regulatory agencies, responding to scientific queries
• Partner closely with Biostatistics, Pharmacovigilance, Medical Affairs, and Health Economics to ensure epidemiological evidence is integrated into broader evidence packages
• Provide epidemiological input into signal detection and benefit-risk assessment activities

Impact of the Role

• Shape the epidemiological evidence foundation for a confidential multi-indication portfolio
• Strengthen the organisation's scientific credibility with regulators through rigorous epidemiological input
• Build internal epidemiology capability and governance standards
• Influence long-term lifecycle and risk management strategy across therapeutic areas

Your Profile

• PhD in Epidemiology (or closely related discipline) required
• Extensive experience (12+ years) in epidemiology within pharmaceutical, biotech, or public health settings, including senior/leadership experience
• Deep expertise in observational study design, causal inference, and pharmacoepidemiological methods
• Demonstrated experience authoring epidemiological content for regulatory submissions and interacting with health authorities
• Track record of leading and developing epidemiology teams
• Strong scientific writing and publication record
• Excellent stakeholder management skills, with experience presenting to senior governance and regulatory bodies