Computational Chemistry Director

Hyper Recruitment Solutions; Cambridge; Hybrid; GBP 90,000 - 150,000; Full time

Job summary

Hyper Recruitment Solutions Ltd in Cambridge is seeking a Director - Computational Chemist to lead strategic computational efforts in drug discovery for neurological disorders and oncology. You will shape the development of advanced simulation platforms and guide cross-functional teams.

The role requires a PhD in computational chemistry, strong experience with FEP/TI in drug discovery, and proven scientific leadership with Python scripting to build scalable workflows.

Qualifications

• PhD in Computational Chemistry or a related field.
• Proven experience in developing/applying modern simulation methods (e.g., FEP/TI) in a drug discovery context.
• Strong Python programming skills and ability to build scalable workflows.
• Evidence of scientific leadership and strategic influence.

Responsibilities

• Oversee development and application of internal simulation platform, focusing on free energy and related molecular simulations.
• Develop and apply advanced molecular simulation and free energy methods to guide compound design.
• Collaborate closely with medicinal chemistry and structural biology teams to integrate computational approaches.
• Validate novel methods against high-quality experimental datasets.

Skills

Python

Scientific leadership

Drug discovery

Education

PhD in Computational Chemistry

Job description

Are you a passionate Senior Level Computational Chemist looking to make a significant impact in the field of drug discovery? A leading biotech organisation in the Cambridge area is seeking a talented strategic and people leader to join their dynamic team. This role offers the chance to work on cutting-edge projects in a collaborative and innovative environment, where your contributions can directly influence the development of new therapies for neurological disorders and oncology.

KEY DUTIES AND RESPONSIBILITIES:

Your duties as Director - Computational Chemist will be varied; however, the key duties and responsibilities are as follows:

1. Contribute to oversee the development and application of the internal simulation platform, with a particular focus on free energy and related molecular simulation approaches.
2. Develop and apply advanced molecular simulation and free energy methods to guide compound design.
3. Collaborate closely with medicinal chemistry and structural biology teams to integrate computational approaches.
4. Validate novel methods against high-quality experimental datasets.

SKILLS AND EXPERIENCE:

To be successful in your application to this exciting role as Computational Chemistry Director, we are looking to identify the following on your profile and past history:

1. PhD in Computational Chemistry or a related field.
2. Proven industry experience in developing and/or applying modern simulation methods (e.g., FEP/TI) in a drug discovery context.
3. Strong programming and scripting skills, ideally in Python, with an interest in developing robust, scalable workflows.
4. Evidence of scientific leadership and strategic influence.

The organisation offers excellent training and career development opportunities, a highly competitive salary, and a benefits package that includes hybrid working options to promote a flexible and inclusive work environment.

Key Words: Computational Chemist / Molecular Simulation / Drug Discovery / Free Energy Methods / Python / Multidisciplinary Teams / Cambridge / Structural Biology / Medicinal Chemistry / Scientific Leadership

Hyper Recruitment Solutions Ltd (HRS) is an Equal Opportunities employer. We welcome applications from anyone who meets the role requirements. HRS exclusively supports the Life Science sectors, combining recruitment expertise with scientific knowledge to help you advance your career.