Comparative Genomics Research Associate (Fixed Term)

CamWebDir; Cambridge; Remote; GBP 40,000 - 60,000; Full time

Job summary

University of Cambridge is seeking a Postdoctoral Research Associate to investigate somatic genomics, aging and cancer across mammalian species. The role combines high-depth sequencing, targeted panels, histology and evolutionary analysis within a collaborative Cambridge-Wellcome Sanger Institute network.

The position offers substantial ownership of a comparative genomics project, with training in experimental methods and data/code dissemination. Fixed-term funding for 3 years at the outset.

Responsibilities

• Develop reproducible genomic workflows; call and quality-control somatic variants; quantify mutation rates and signatures; infer clone sizes and dynamics; and test for selection.
• Design targeted gene panels and comparative analyses accounting for species, tissue, age and sampling structure.
• Model clonal growth in relation to lifespan, body size, tissue architecture and cancer risk, including comparisons with human datasets.
• Contribute to sample collection, histology, laser-capture microdissection and DNA extraction, with training and support.
• Maintain accurate sample metadata and quality-control records.
• Collaborate with colleagues in Cambridge, at the Wellcome Sanger Institute and across partner institutions; prepare manuscripts and reusable data and code; present findings; and support students and junior colleagues.
• Manage day-to-day work independently, communicate progress and risks, and help shape the project's scientific direction.

Job description

University of Cambridge is seeking a Postdoctoral Research Associate to investigate somatic genomics, aging and cancer across mammalian species. The role combines high-depth sequencing, targeted panels, histology and evolutionary analysis within a collaborative Cambridge-Wellcome Sanger Institute network.

The position offers substantial ownership of a comparative genomics project, with training in experimental methods and data/code dissemination. Fixed-term funding for 3 years at the outset.