Clinical Scientist

Great Ormond Street Hospital for Children NHS Foundation Trust; City Of London; Hybrid; GBP 56,000 - 64,000; Full time

Job summary

A leading children's healthcare provider in London is seeking a Clinical Scientist specializing in genomic service delivery. The ideal candidate has a strong molecular genetics background and excellent communication skills. This role offers flexible working patterns and a salary range of £56,276 to £63,176 annually. The successful candidate will contribute to diagnostic services and innovative practices in a diverse and inclusive environment.

Qualifications

• At least 2 years postgraduate experience in a genomics laboratory.
• Extensive knowledge of clinical genomics.
• Knowledge of structural chromosome rearrangements.

Responsibilities

• Establish and validate new techniques/tests.
• Manage and deliver a diagnostic service.
• Communicate effectively with team members.

Skills

Molecular genetics techniques

Cytogenetic techniques

Genomic CNV analysis

Effective communication

Troubleshooting

Use of DNA/Genetic databases

Education

First or Second Class Degree in Molecular Biology, Genetics, Biochemistry or related subject

HCPC Clinical Scientist Registration Certificate

Tools

Next Generation Sequencing Applications

Sanger Sequencing

Microarray

FISH

Job description

Overview

Great Ormond Street Hospital for Children NHS Foundation Trust is seeking an enthusiastic, self-motivated scientist with experience of rare disease genomic service delivery and a sound understanding of molecular and cytogenetic techniques and analysis. Applications are invited from State Registered Clinical Scientists in Genomics; scientists close to registration will also be considered. Applications from scientists with a cytogenetic background would be welcomed. The scientists will join the North Thames Rare Disease Laboratory Hub at Great Ormond Street Hospital. The closing date is 07 November 2025.

Accomplished communication and organisational skills are required. An interest in quality (ISO15189:2022), innovation/automation, or workforce development/training would be an advantage. We support flexible and/or hybrid working patterns. For Clinical Scientists, after a successful probation period, there is a requirement to work on-site for 40% of working hours. Informal telephone enquiries can be made to: [e-mail]

Main duties of the job

The Rare Disease Laboratory has an establishment of approximately 180 staff including technologists, Clinical Scientists, translational scientists, bioinformaticians and administrative support. Along with two Clinical Genetics teams we form a strategic Genetics Unit withinthe hospital and provide North London with a Regional Genetics Service serving a population of approximately 10 million. The laboratory offers in-house diagnostic services for molecular and cytogenetic testing in accordance with the NHS England Genomic Test Directory, including prenatal and postnatal testing using Next generation sequencing, SNP microarray, karyotyping, FISH, MLPA, qPCR, ddPCR, NIPD and other targeted tests. We are involved in the NHSE GMS Whole Genome Sequencing programme for North Thames patients and specialist WGS for larger areas of England. We are involved in collaborative research and development projects with colleagues at UCL Institute of Child Health and Institute of Neurology as part of the UCL Partners Academic Health Sciences Centre.

About us

GOSH is committed to recruiting the best person for the job based on ability and merit, through a fair, open, consistent and non-discriminatory process. We are committed to being a diverse and inclusive employer with staff networks and policies to support Equality, Diversity and Inclusion. We welcome applications from all backgrounds and are proud to be Disability Confident, a member of the Business Disability Forum and a Stonewall Diversity Champion. Staff networks are open to all employees.

Job responsibilities

The full job description provides an overview of the key tasks and responsibilities of the role, and the person specification outlines the qualifications, skills, experience and knowledge required. Please view the attachment(s) below for the detailed documents.

Person Specification

GOSH Culture and Values

• Our Always values
• Knowledge and understanding of diverse backgrounds and perspectives
• Understanding of Diversity and Inclusion challenges in the workplace
• Demonstrable contribution to advancing Equality, Diversity and Inclusion in the workplace
• First or Second Class Degree in Molecular Biology, Genetics, Biochemistry or related subject
• HCPC Clinical Scientist Registration Certificate

Experience/Knowledge

• At least 2 years postgraduate experience in a genomics laboratory
• Extensive knowledge of clinical genomics and a demonstrable track record in the delivery of a diagnostic service
• Knowledge of structural chromosome rearrangements and segregation, CNV analytical methods and clinical applications OR knowledge and experience of molecular variant classification in accordance with ACGS guidance and their application for all modes of inheritance
• Track record of scientific publications/presentations
• Evidence of supervising/training other staff
• Experience with laboratory information and quality management systems

Skills/Abilities

• Skilled in the use and application of molecular genetics and/or cytogenetic techniques
• Skilled in genomic CNV analysis by use of G banded chromosomes / FISH / Microarray OR Skilled in Next Generation Sequencing Applications / Sanger Sequencing / Dosage analysis
• Able to establish and validate new techniques/tests including ability to troubleshoot. Willing to adapt to changes in methodology
• Computer literate, including use of DNA/Genetic databases, analytical software, variant classification
• Able to communicate effectively both verbally and in writing (by email and by appropriate documentation)
• Able to write protocols

Disclosure and Barring Service Check

This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and a submission for Disclosure to the Disclosure and Barring Service will be required.

Address

Great Ormond Street Hospital for Children NHS Foundation Trust

Salary

£56,276 to £63,176 a year, inclusive pro rata

Contract

Permanent

Working pattern

Full-time, Part-time

Reference number

271-GEN-7498040

Job locations

Great Ormond Street Hospital for Children NHS Foundation Trust