Clinical Science Director, Early Clinical Development, CVRM

ASTRAZENECA UK LIMITED; Hartford; On-site; GBP 40,000 - 60,000; Full time

Job summary

A leading pharmaceutical company is seeking a Clinical and Translational Scientist to support clinical strategy development in the UK. The candidate will have substantial experience in metabolic disease and a Ph.D., with responsibilities including contributing to pre-clinical and early phase trials and engaging in cross-functional team collaborations. In this role, the mission is to impact patients' lives positively by driving innovative therapies in cardiovascular, metabolic, and kidney disease areas. Excellent communication and a strong delivery focus are essential.

Qualifications

• Ph.D. with a minimum of 5 years of experience in clinical or translational research in cardiovascular, metabolic, or kidney disease.
• Strong experience in biomarker evaluation and human target validation.
• Proven ability in writing clinical protocols and supporting documents.

Responsibilities

• Support scientific and translational science development for clinical strategies.
• Contribute to pre-clinical and early phase clinical trials.
• Collaborate with cross-functional teams to develop strategies for metabolic disorder therapies.

Skills

Clinical research

Translational science

Biomarker evaluation

Excellent communication skills

Strong delivery focus

Education

Ph.D. in relevant field

Job description

As a clinical and translational scientist, your core accountability will be scientific support for the scientific and translational science development and execution of clinical strategies based upon your established expertise including the latest thinking about mechanisms of disease, diagnostic approaches, current treatment options, drug development trends, and regulatory requirements in relevant disease and therapeutic areas. You will contribute to pre-clinical and early phase clinical trials and related clinical research projects for potential therapies that are targeting metabolic diseases, as well as serving as an expert on the translational human target validation, clinical design, document generation, conduct, monitoring, data interpretation, and reporting of these studies. Additional tasks include supporting regulatory documentation, liaison with discovery scientists, regulatory, clinical and commercial colleagues, developing and managing external collaborations, and developing a deep knowledge of the literature pertaining to the products under development. You will also work on cross-functional teams within our early clinical development group and across the broader early CVRM organization that are framing our strategies and development plans for potential therapies that are targeting major metabolic disorders, given that these disorders intersect with cardiovascular and kidney diseases and influence disease progression.

We are looking for an experienced scientist with clinical and/or translational research experience in metabolic disease and obesity. Your ambition to improving patients' lives will involve you in a team working in a multidisciplinary environment, driving the translational and clinical development of novel innovative therapies in CVRM diseases. In this role, you will have the opportunity to work at the forefront of early clinical and translational research.

Qualifications

• Ph.D with minimum of 5 years of experience in clinical or translational research in cardiovascular, metabolic, or kidney disease
• Experience in biomarker evaluation, human target validation, or translational science knowledge
• Proven experience in writing clinical synopsis/protocols, regulatory materials and clinical study supporting documents
• Experience in assisting in the design and execution of clinical studies as well as researching patient characteristics, treatments and care
• Demonstratable clinical scientific knowledge in either cardiovascular, metabolism and/or kidney disease
• Good publication track record
• Track record of strong delivery focus, excellent communication skills and ability to collaborate successfully on global cross-disciplinary teams

Preferred Qualifications

• Advanced Masters or doctoral degrees
• Experience working in an early clinical trial/research setting within the pharmaceutical industry including preparation of documents supporting clinical trials.

Location

Office based in Cambridge, UK

Are you ready to bring new insights and fresh thinking to the table? Good, because we can't wait to hear from you.