BRF GeMS Research Scientist

ZipRecruiter; London; On-site; GBP 35,000 - 55,000; Full time

Job summary

Join a leading biomedical research institute as a BRF GeMS Research Scientist. This full-time role offers the chance to work on groundbreaking genetic modification projects and contribute to vital research. Collaborate with top scientists in a dynamic environment, utilizing state-of-the-art facilities to develop innovative animal models. Your expertise in molecular biology and CRISPR-Cas9 will be key in advancing scientific discovery. Enjoy a supportive workplace culture that values diversity and encourages professional growth. This is an exciting opportunity to make a meaningful impact in the field of biomedical research.

Benefits

Generous Leave

Pension Scheme

Health & Well-being Programs

Discounted Gym Memberships

Childcare Support Allowance

Subsidised On-site Restaurant

Qualifications

• Degree in a biological subject with experience in molecular biology.
• Understanding of CRISPR-Cas9 design and related techniques.

Responsibilities

• Assist in designing reagents and validating genetically modified alleles.
• Perform core molecular biology techniques including PCR and genotyping.

Skills

Molekularbiologie

Mammalian Cell Culture

CRISPR-Cas9

DNA Analysis Software

Team Collaboration

Education

Biological Degree

Tools

Genome Browsers

NGS Sequencing Technologies

Job description

Job Description

BRF GEMS Research Scientist

Reports to: GeMs Senior Manager Molecular & Cell.

This is a full-time, permanent position on Crick terms and conditions.

Working pattern: Monday – Friday.

About us…

The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose, and treat illnesses such as cancer, heart disease, infectious diseases, and neurodegenerative conditions.

The Crick is a place for collaboration, innovation, and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We’ve removed traditional boundaries of departments, divisions, and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.

About the role…

The Genetic Modification Services (GeMS) provide a breadth of specialist skills and resources for the design, creation, production, storage, and use of genetically altered animals, germplasms, and cell lines, together with ancillary techniques.

The post-holder will join the genetic modification team and assist in the design of molecular reagents used in both in vivo and in vitro genetic engineering experiments for animal and disease models, and the subsequent genetic validation of the resulting mutant strains.

If you have a degree in a biological subject and experience in molecular biology, mammalian cell culture, and CRISPR-Cas9, this could be a perfect opportunity for you to join the team.

You will participate in the creation of new animal models, taking a lead role towards the development of a subset of projects. As such, you will be expected to develop a detailed understanding of genetic modification and mouse genetics and will be expected to follow breeding progress, ensuring that the 3Rs principles for in vivo research (replacement, reduction, and refinement) underpin all work undertaken.

What you will be doing

As a BRF GeMS Research Scientist at the Crick, you will:

• Assist in the design of reagents and validation of new genetically modified alleles.
• Perform core molecular biology techniques including LR-PCR, PCR, digital droplet or qPCR, molecular cloning, NGS sequencing technologies, genotyping, and sequence analysis.
• Maintain mESC cultures and perform in vitro CRISPR-facilitated and classical gene targeting experiments using electroporation, nucleofection, and lipofection. Engage in out-of-hours cell culture work rota.
• Participate in the creation of new animal models, taking a lead role towards the development of a subset of projects; working towards deadlines, troubleshooting, and seeking support when needed.
• Maintain accurate records, ensuring scientific work is carried out efficiently and in accordance with legal frameworks.
• Promote awareness of health and safety guidance and legislation.

About you…

You will bring…

• A degree or equivalent in a biological subject.
• Experience in molecular biology and mammalian cell culture.
• Understanding of CRISPR-Cas9 design and associated techniques.
• Experience with genome browsers, DNA analysis software, and CRISPR guide on/off target specificity software.
• Commitment to professional development (CPD).
• Experience contributing effectively to a team with a collaborative approach.

To see the complete Job Description, click here for more info.

About Working at the Crick…

Our values

Everyone who works at the Crick has a valuable role in advancing our mission and shaping our culture!

• We are bold. We make space for creative, dynamic, and imaginative ideas and approaches. We’re not afraid to do things differently.

• We are open. We’re highly collaborative and transparent, making our activities visible to the outside world.

• We are collegial. We show respect, work cooperatively, and support the wider community.

At the Francis Crick Institute, we believe that these values are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of background, identity, or circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We will make reasonable adjustments if needed—just let us know when you apply. For application assistance, contact: [e-mail]

To find out more about life at the Crick, click here.

What will you receive?

We offer an extensive range of benefits to support well-being and development:

• Visas: Sponsorship to work in the UK.
• Generous Leave: 28 days of annual leave plus additional days over Christmas and bank holidays.
• Pension Scheme: Defined contribution pension with up to 16% employer contributions.
• Health & Well-being: 24/7 GP services, occupational health, mental health support, eye care vouchers, and discounted healthcare plans.
• Work-Life Balance: Backup care, childcare support, and annual leave purchase options.
• Crick Networks: Support groups, community, and social events.
• Perks: Gym discounts, bike schemes, shopping discounts, subsidized on-site restaurant, and social spaces.
• Development & Recognition: Training, mentoring, and performance-linked progression.