Bioinformatician - Pathogen

Ellison Institute of Technology Oxford

Oxford

Hybrid

GBP 50,000 - 75,000

Full time

5 days ago

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Benefits offered by this job

Travel allowance

Bonus

Enhanced holiday pay

Pension

Life Assurance

Income Protection

Private Medical Insurance

Hospital Cash Plan

Therapy Services

Perk Box

Electric Car Scheme

Job summary

Ellison Institute of Technology (EIT) in Oxford seeks an experienced Bioinformatician to analyze, validate and improve bioinformatics workflows that translate raw sequencing data into actionable insights for infectious diseases and metagenomics.

You will work with pathogen-specific and metagenomic data, collaborating closely with wet-lab scientists to apply microbial profiling, taxonomic classification, and antimicrobial resistance analyses. A PhD and strong Python/Bash skills are essential.

Qualifications

Doctorate-level expertise in Bioinformatics, Computational Biology, Microbiology, Genomics or a related field.
Hands-on experience analysing next-generation sequencing data, ideally in metagenomics or infectious diseases.
Strong programming skills in Python and Bash; familiarity with R desirable.
Exposure to workflow managers (e.g., Nextflow) and container technologies (e.g., Docker).

Responsibilities

Develop, apply and improve reproducible bioinformatics workflows for WGS and metagenomic data analysis.
Support interpretation of complex sequencing datasets considering contamination and mixed organisms.
Collaborate with wet-lab scientists and other bioinformaticians to ensure robust analyses.
Stay current with infectious disease genomics trends and implement improvements to workflows.
Contribute to a collaborative, inclusive team environment and knowledge sharing.

Skills

Python

Bash

Nextflow

Docker

Git

Metagenomics

Infectious diseases

Education

PhD in Bioinformatics

Tools

Docker

Nextflow

Git

Job description

Join us at EIT:

At the Ellison Institute of Technology (EIT), we're on a mission to translate scientific discovery into real world impact. We bring together visionary scientists, technologists, engineers, researchers, educators and innovators to tackle humanity's greatest challenges in four transformative areas:

Health, Medical Science & Generative Biology

Food Security & Sustainable Agriculture

Artificial Intelligence & Robotics

Join us at EIT:

Health, Medical Science & Generative Biology

Food Security & Sustainable Agriculture

Climate Change & Managing CO₂

Artificial Intelligence & Robotics

Welcome to the Pathogen Project:

Within this ecosystem, the Pathogen Program exemplifies EIT's dedication to transformative science. It seeks to revolutionise the diagnosis and treatment of infectious diseases by leveraging Whole Genome Sequencing (WGS)-based metagenomic and pathogen-specific analytical tools. This initiative is building a global, \"Always On\" pathogen metagenomics system designed to enhance diagnostics, provide early epidemic warnings, and guide treatment through antimicrobial resistance profiling. Enabled by Oracle Inc.'s cloud-computing scale and security, the Pathogen Mission is advancing toward certified diagnostic products for deployment in laboratories, hospitals, and public health organisations worldwide.

The role:

At EIT we are seeking an experienced and detailed orientated Bioinformatician to work shoulder-to-shoulder with senior scientists to analyse, validate and improve bioinformatics workflows that turn raw sequencing data into actionable insights. This is an ideal role for someone early in their career who is eager to develop their skills in infectious disease genomics, microbial sequence analysis and reproducible computational biology, while seeing their work contribute to products with real-world clinical impact.

The role will involve working with a range of next-generation sequencing datasets, including pathogen-specific and metagenomic data. You will work closely with wet lab scientists to apply analytical approaches such as microbial profiling, taxonomic classification, and antimicrobial resistance analysis to experimental data and interpret the results. We are particularly interested in candidates who have practical exposure to metagenomic methods and are keen to deepen that expertise in a translational research environment.

Key Responsibilities:

Develop, apply and improve reproducible bioinformatics workflows for the analysis of whole genome and metagenomic sequencing data, including quality control, assembly, taxonomic classification, antimicrobial resistance prediction, variant analysis and strain characterisation

Support interpretation of complex sequencing datasets, assessing the suitability of analytical approaches and accounting for factors such as contamination, mixed organisms, host background, low microbial biomass and ambiguous taxonomic assignments

Use scripting and good programming practices to develop clear, reliable and reproducible bioinformatics solutions, and actively support colleagues by sharing expertise, reviewing code and contributing to collaborative problem-solving

Stay current with advances in infectious disease genomics, metagenomic analysis, antimicrobial resistance analytics, and microbial bioinformatics, suggesting incremental improvements to existing workflows

Engage in a collaborative, inclusive and high-performing team environment by sharing knowledge, supporting colleagues and contributing to continuous improvement

Requirements

Essential Knowledge, Skills and Experience:

Doctorate-level expertise (PhD or equivalent) in Bioinformatics, Computational Biology, Microbiology, Genetic Epidemiology, Genomics or a related field, combined with hands-on bioinformatics or computational biology experience

Hands-on experience analysing next-generation sequencing data, ideally in metagenomics, microbial genomics, infectious diseases, or a related field

Understanding of metagenomic analysis principles and the challenges associated with interpreting sequencing data from complex microbial communities, such as distinguishing co-occurring organisms, contamination, host/background signal, reference database limitations, taxonomic resolution and false-positive results

Strong programming skills in Python and Bash, with experience developing reproducible bioinformatics scripts, pipelines and data analysis workflows; familiarity with R is desirable

Exposure to workflow management systems (e.g. Nextflow) and container technologies (e.g. Docker), with an understanding of their role in developing reproducible bioinformatics workflows

Clear communicator, curious learner, and team-oriented problem solver

Desirable Knowledge, Skills and Experience:

Experience working in infectious diseases diagnostics with techniques such as clinical metagenomics or targeted sequencing

Exposure to cloud computing platforms (e.g. OCI, AWS or GCP) and/or high-performance computing (HPC) environments (e.g. Slurm) for running and managing bioinformatics analyses

Experience using version control (e.g. Git) to develop, maintain and share reproducible bioinformatics code and workflows within a collaborative team

Familiarity with short- and long-read sequencing technologies (e.g. Illumina and Oxford Nanopore Technologies) and an understanding of their respective applications, strengths and limitations

Interest in developing skills in data visualisation, statistical analysis or machine learning methods to support genomic data analysis and interpretation

Benefits:

Travel allowance

Bonus

Enhanced holiday pay

Pension

Life Assurance

Income Protection

Private Medical Insurance

Hospital Cash Plan

Therapy Services

Perk Box

Electric Car Scheme

Working Together - What It Involves:

You must have the right to work permanently in the UK with a willingness to travel as necessary. In certain cases, we can consider sponsorship, and this will be assessed on a case-by-case basis