Associate Director - Oncology Targeted Delivery- Safety Science & Discovery

ASTRAZENECA UK LIMITED; Hartford; Hybrid; GBP 50,000 - 75,000; Full time

Job summary

A leading pharmaceutical company in the UK is seeking a scientist with a PhD in Toxicology or a related field. Responsibilities include directing discovery toxicology strategies, conducting innovative studies, and collaborating with multidisciplinary teams to advance drug discovery. The ideal candidate will have significant industry experience and a strong scientific background. A supportive company culture encourages bold thinking and personal development, offering a flexible working environment while promoting in-person collaboration three days a week.

Benefits

Flexible work environment

Collaborative company culture

Qualifications

• Strong scientific track record and willingness to challenge conventional thinking.
• Substantial experience in toxicology, drug discovery and development.
• Strong background in building and validating complex in vitro models.

Responsibilities

• Direct discovery toxicology strategies to predict and mitigate safety risks.
• Design and conduct innovative toxicology studies.
• Collaborate with cross-functional teams in Clinical Pharmacology and Safety Sciences.

Skills

Excellent communication skills

Collaboration

Problem-solving skills

Understanding of toxicology

Experience in drug discovery

Education

PhD in Toxicology, Pharmacology, Molecular & Cell Biology, Oncology or Immunology

Job description

Responsibilities

• As a core member of multidisciplinary drug discovery teams, direct discovery toxicology strategies to predict, assess, and mitigate target‑and‑modality‑related safety risks, focusing on ADCs and RCs.
• Design and conduct innovative toxicology studies (in vitro, ex vivo, and in vivo) to predict, assess, and mitigate target‑and‑modality‑related safety risks in discovery programs and inform decision‑making.
• Develop and implement innovative safety science solutions and research proposals to advance cutting‑edge science and technologies in line with business and safety needs.
• Maintain expertise in preclinical safety strategies for ADCs and RCs, with an awareness of industry trends.
• Collaborate with cross‑functional teams within Clinical Pharmacology and Safety Sciences (CPSS) and Oncology R&D to develop and adapt safety screening strategies for advancing drug discovery programs.
• Publish in high‑quality, peer‑reviewed journals, and present at internal scientific meetings and external conferences. Excellent scientist with a PhD (or equivalent) in Toxicology, Pharmacology, Molecular & Cell Biology, Oncology, Immunology or related field, a strong scientific track record, and a willingness to challenge conventional thinking.
• Substantial experience in toxicology, drug discovery and development, with a strong track record of independent research in industry, biotech, or academic settings.
• Strong background in building and validating complex in vitro models for toxicology, delivering decision‑making data.
• Expertise in Oncology and targeted therapeutics and awareness of drug safety aspects of ADCs and/or RCs.
• Experience in designing and executing in vitro and/or in vivo experiments to determine the effects of therapeutics on biological systems.
• Ability to develop testable hypotheses, and drive scientific learning.
• Collaborative, team‑oriented approach, with proven problem‑solving skills focused on goals and the capacity to coordinate tasks across multiple projects.
• Excellent communication, presentation, interpersonal and influencing skills across levels and subject areas with a strong desire to drive personal development.

Qualifications

• Excellent scientist with a PhD (or equivalent) in Toxicology, Pharmacology, Molecular & Cell Biology, Oncology, Immunology or related field, a strong scientific track record, and a willingness to challenge conventional thinking.
• Substantial experience in toxicology, drug discovery and development, with a strong track record of independent research in industry, biotech, or academic settings.
• Strong background in building and validating complex in vitro models for toxicology, delivering decision‑making data.
• Expertise in Oncology and targeted therapeutics and awareness of drug safety aspects of ADCs and/or RCs.
• Experience in designing and executing in vitro and/or in vivo experiments to determine the effects of therapeutics on biological systems.
• Ability to develop testable hypotheses, and drive scientific learning.
• Collaborative, team‑oriented approach, with proven problem‑solving skills focused on goals and the capacity to coordinate tasks across multiple projects.
• Excellent communication, presentation, interpersonal and influencing skills across levels and subject areas with a strong desire to drive personal development.

Desirable Skills/Experience

• Knowledge in incorporating quantitative systems pharmacology and toxicology (QSP/QST) approaches with in vitro data to predict clinical safety risks is a plus.
• In vitro imaging expertise (e.g., confocal microscopy, imaging flow cytometry, and other high‑throughput methods), as well as hands‑on experience with mAb/ADC internalization assays, are desirable.

Company Culture

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life‑changing medicines. In‑person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that does not mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

AstraZeneca is a place where diverse minds come together united by a shared passion to learn, grow, and discover. Our scientific community seamlessly fuses academia with industry expertise. We celebrate successes while learning from the best. With female leaders holding 45% of senior roles internally and 475 pre‑clinical collaborations across 26 countries externally, we are committed to expediting research in some of the hardest‑to‑treat cancers. Join us to build a meaningful career as part of a team dedicated to improving the lives of millions with cancer.