Associate Director, AI for Oncology Clinical Development

ASTRAZENECA UK LIMITED; Hartford; On-site; GBP 109,000 - 163,000; Full time

Job summary

AstraZeneca UK Limited is seeking a technical lead to drive AI strategy for oncology clinical development. You will guide high-stakes AI projects across study design, data governance, and decision-making processes, collaborating with clinical development, biometrics, and regulatory teams.

You will foster external collaborations and contribute to scholarly publications in premier ML and clinical AI journals, advancing the late-stage drug pipeline and our objectives.

Qualifications

• PhD plus at least 2+ years' work experience outside of PhD with measurable impact.

Responsibilities

• Contribute to AI strategy and roadmap for Oncology clinical development.
• Serve as a technical lead in matrixed teams to deliver complex AI projects.
• Evaluate and develop cutting-edge AI methods across problem definition, data, governance, and validation.
• Partner with clinical development, biometrics, regulatory, and study teams to integrate AI into study design and decision-making.
• Establish external collaborations to access novel capabilities and advance the AI roadmap.
• Represent AstraZeneca at conferences; contribute publications in ML and clinical AI venues.

Education

PhD in a quantitative discipline such as computer science, bioinformatics, computational biology, mathematics, physics, biophysics, computational neuroscience, biostatistics

Job description

Drug discovery has benefitted enormously in the current AI era yet comprises only a portion of the journey to bring new treatments to those in need. The final step - clinical drug development - is oft overlooked, despite requiring a significant proportion of time and investment. In the AI for Clinical Development team at AstraZeneca, we're reimagining the process of clinical development. Our vision is to bring safe, efficacious treatments to patients in a way that quantifiably improves our chance to do this faster, more cost-effectively, and with reduced patient burden. In this role, you will be a technical lead to help us leverage the power of AI to the fullest, alongside our other computational, statistical, and machine learning tools. You will work across the enterprise to define and deliver on AstraZeneca's most pressing clinical development questions. You will proactively collaborate in cross-functional teams spanning AstraZeneca's key Oncology foci of hematology, cell therapy, antibody-drug conjugates, small molecules, and biologics. This is an unprecedented, high visibility opportunity to invent new ways to leverage data, models, and learnings across the spectrum of cancer biology and drug modalities - and importantly, you and the team will apply these new methods to measurably advance the late-stage drug pipeline and our group's ambition.

Responsibilities

• Contribute to the AI strategy and roadmap for Oncology early and late phase clinical development
• Serve as a key technical lead and contributor in matrixed teams to deliver complex, high-stakes AI projects
• Evaluate and develop cutting-edge AI methods in one or more areas of problem definition, data considerations, governance, algorithm development, validation, and adoption
• Partner with clinical development, biometrics, regulatory, and study teams to develop and then validate novel AI solutions into clinical study design, execution, strategy, and decision-making
• Establish and maintain external collaborations with academic institutions, technology partners, and industry consortia to access novel capabilities and advance the AI roadmap
• Represent AstraZeneca at scientific conferences, standards bodies, and peer-reviewed venues; contribute first- or last-author publications in leading ML and clinical AI journals

Qualifications

• PhD in a quantitative discipline such as computer science, bioinformatics, computational biology, mathematics, physics, biophysics, computational neuroscience, biostatistics
• At least 2+ years' work experience outside of PhD with measurable impact (e.g. models delivered, patents, SaMD filings, first-author publications, open-source projects, standards-body participation)

Technical requirements

• Exceptional software development and coding skills, leveraging frontier coding agent frameworks; knowledge of computing hardware a plus
• Deep experience, knowledge, and understanding of one or more fields of biology
• Deep understanding of machine learning fundamentals, with domain expertise in one or more of the following -
• Training and tuning foundation models
• Bayesian inference
• Temporal modeling
• Multimodal integration and modeling
• Model calibration and domain adaptation
• Data-centric AI: acquiring, creating, and curating datasets for model training / post-training / benchmarking / evals
• Model and data evaluations and benchmarking
• Model interpretability
• Model post-training and alignment

Preferred Skills

• Deep expertise in cancer biology
• Experience working with biological data such as molecular (e.g. DNA, RNA, protein), imaging (radiology, microscopy), or clinical text (e.g. EHR, clinical notes)
• Experience in drug development including but not limited to clinical trial design, biomarker discovery, companion diagnostics, dosing, safety, endpoints, and regulatory
• Experience in a matrixed global organization spanning multiple sites and therapy areas
• Up to date with the latest AI research and tools, proactively trying out those of interest, and ability to discern hype from true added value

Compensation and Benefits

• The annual base pay for this position ranges from $144K to $216K.
• Our positions offer eligibility for various incentives - an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles.
• Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.