13511- Postdoctoral Research Fellow

University of Edinburgh; City of Edinburgh; On-site; GBP 41,000 - 49,000; Full time

Job summary

A leading research institution in Edinburgh offers an exciting postdoctoral research opportunity focusing on glioblastoma's transcriptional and epigenetic mechanisms. Ideal for PhD graduates with a strong background in cancer genomics and chromatin regulation, this role involves utilizing innovative gene therapy approaches and collaborating on multiple research projects. The position demands expertise in molecular mechanisms, gene regulation, and a passion for advanced therapies, with a competitive salary range of £41,064 to £48,822 per annum.

Qualifications

• Demonstrated track record in molecular and cellular mechanisms of stem cells, development or cancer.
• Good understanding of gene regulation, stem cell or cancer biology.
• Past experience or enthusiasm to develop bioinformatics skills.

Responsibilities

• Explore the transcriptional and epigenetic mechanisms underpinning glioblastoma.
• Utilize latest genomic and biochemical technologies.
• Collaborate across multiple projects focused on cancer therapies.

Skills

Molecular and cellular mechanisms expertise

Publication record in chromatin regulation

Understanding of gene regulation biology

Experience with imaging techniques

Bioinformatics skills for genomics analysis

Education

PhD in a related field

Job description

Grade UE07: £41,064- £48,822 per annum.

CMVM, School of Regeneration and Repair.

Full Time: 35 hours per week.

Fixed Term: 12 months.

Opportunity

The laboratory of Prof Steven Pollard explores molecular and cellular mechanisms that regulate neural stem cells and how these become deregulated in brain cancers. We now a postdoctoral research position available to explore the transcriptional and epigenetic mechanisms underpinning glioblastoma, with a focus on the SOX family of transcription factors and the role of histone regulation in driving disease. We will explore novel strategies to target the chromatin landscapes using innovative gene therapy approaches.

You will build on our recent discoveries that have identified key transcription factors, regulatory enhancers and epigenetic reconfigurations underpinning glioblastoma. Specifically, you will use a combination of the latest biochemical, genome editing and genomics technologies, to dissect the mechanisms underlying the identity of glioblastoma stem cells and roles of key histone regulatory pathways. This knowledge is also being deployed in our therapeutics discovery programs, with gene therapy strategies aimed at targeting glioblastoma stem cell identity.

These projects build upon our recently reported publications (Cell, Cell Stem Cell, Nature Genetics and Nature Comms). This is a particularly appealing opportunity for recently completed PhD students with a background in cancer genomics and chromatin regulation who may now wish to move into the related field of cancer advanced therapies.

The salary for this post is £41,064 to £48,822 per annum.

Skills and attributes

• Demonstrated track record in molecular and cellular mechanisms of stem cells, development or cancer, ideally with strong publication record in chromatin regulation and human primary cancer cell line models.
• Good understanding of the fundamental biology of gene regulation, stem cell or cancer biology, with demonstrated expertise in the latest techniques from imaging, genomics, biochemistry or cell biology.
• Past experience, or enthusiasm to develop bioinformatics skills for analysis of genomics/NGS datasets.
• Ability to work well collaboratively across multiple projects.