13301 - Post-Doctoral Research Associate

University of Edinburgh; City of Edinburgh; On-site; GBP 41,000 - 49,000; Full time

Job summary

A prestigious research institution in Edinburgh seeks a postdoctoral researcher for a project investigating immune-cold colorectal cancer immunotherapy. This full-time position offers a salary of £41,064 to £48,822 per annum for a duration of 36 months. The ideal candidate has a PhD in cancer biology or a related field and experience in project success, animal models, and bioinformatics. Apply for this opportunity to contribute to cutting-edge cancer research.

Qualifications

• PhD in immune-oncology, cancer biology or related biomedical field.
• Evidence of successful project completion, especially first author publications.
• Experience with animal cancer models and organoid culture systems.
• Bioinformatic experience in spatial data analysis or RNAseq.
• Ability to communicate complex information clearly.

Responsibilities

• Investigate novel methods to make immune‑cold colorectal cancer responsive to immunotherapy.
• Use mouse models, patient-derived organoids, and spatial transcriptomics for research.
• Develop therapeutic approaches to enhance immunotherapy efficacy.

Skills

Project completion

Animal cancer models

Organoid culture systems

Bioinformatics

Clear communication

Education

PhD in immune-oncology, cancer biology or related biomedical field

Tools

RNAseq analysis

Long read technologies

Job description

Opportunity

We seek a postdoctoral researcher to carry out a research project to investigate novel methods to make immune‑cold colorectal cancer responsive to immunotherapy. A Cancer Research UK funded postdoctoral position is available in the lab of Dr Kevin Myant (https://institute-genetics-cancer.ed.ac.uk/research/research-groups-a-z/myant-group). The project aims to investigate how targeting RNA splicing can activate immune responses in immune‑cold colorectal cancer. The project will use immune‑competent mouse models, patient‑derived human organoid models and spatial transcriptomics to determine how cancer cells and the tumour immune microenvironment respond to RNA splicing disruption. We will utilise this data to develop novel therapeutic approaches to enhance the efficacy of immunotherapies in this disease. Ideally suited to a researcher with a background in immune‑oncology and spatial analysis. For more information, please contact Dr Kevin Myant ([e-mail]).

Position details

This post is fixed‑term (for 36 months) with potential for a further 3‑year extension based on the meeting of key objectives and full‑time (35 hours per week). The salary for this post is at Grade UE07: £41,064 to £48,822 per annum.

Your skills and attributes for success

• A PhD in immune‑oncology, cancer biology or a related biomedical field.
• Previous evidence of successful project completion, in particular first author publications.
• Experience working with animal cancer models and organoid culture systems.
• Bioinformatic experience, in particular analysis of spatial data, RNAseq analysis or experience of long read technologies.
• Ability to communicate complex information clearly.