Postdoctoral Position (M/F): Development of SPAK Activators and Inhibitors for KCC2 Regulation

CNRS; France; Sur place; EUR 20 000 - 40 000; Plein temps

Résumé du poste

A leading research organization in France is seeking a full-time researcher to conduct compound screening for SPAK activators and inhibitors. The role focuses on advanced microscopy techniques and validation in epilepsy models. Candidates should have a PhD in Neurosciences or related field, with expertise in designing interfering peptides and working with neuronal cultures. This position offers an opportunity to contribute to cutting-edge neuroscience research.

Qualifications

• Expertise in designing interfering peptides and performing compound screenings.
• Experience with neuronal culture and advanced microscopy techniques.

Responsabilités

• Conduct compound screening to identify SPAK activators and inhibitors.
• Assess selected compounds through chloride imaging in hippocampal neurons.
• Validate candidate proteins in in vitro and in vivo models.

Connaissances

Designing interfering peptides

Compound library screening

Chloride imaging

Molecular screening and compound characterization

Advanced microscopy techniques

Neuronal culture and transfection

Immunostaining

Super-resolution imaging

Formation

PhD in Neurosciences or related field

Description du poste

Organisation/Company CNRS Department Plasticité du cerveau Research Field Neurosciences Biological sciences Researcher Profile First Stage Researcher (R1) Country France Application Deadline 28 Nov 2025 - 23:59 (UTC) Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 1 Jan 2026 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Compound screening to identify SPAK activators and inhibitors regulating the KCC2 transporter in hippocampal neurons in vitro and in vivo.

• Design interfering peptides and perform compound library screening to identify SPAK activators and inhibitors
• Assess the selected compounds through chloride imaging in cultured hippocampal neurons
• Validate 2–3 preselected candidate proteins in vitro and in an in vivo epilepsy model
• Chemistry: molecular screening and compound characterization
• Neuroscience: advanced microscopy techniques, neuronal culture and transfection, immunostaining, and super‑resolution imaging