Postdoctoral Position in Microbiology - Streptococcus pneumoniae cell cycle regulation de Duve [...]

IU International University of Applied Sciences; Strasbourg; Sur place; EUR 40 000 - 70 000; Plein temps

Résumé du poste

An innovative research group is seeking a postdoctoral researcher for an ERC-funded project focused on the cell cycle regulation of the pathogen Streptococcus pneumoniae. This role offers a unique opportunity to engage in cutting-edge research combining genetics, molecular biology, and bioinformatics. The successful candidate will work independently and collaboratively to uncover novel insights into bacterial growth and antibiotic resistance. With a minimum two-year appointment and potential for extension, this position provides a platform for significant academic achievement and contribution to vital research in microbiology.

Qualifications

• PhD in relevant field with strong academic record.
• Experience with S. pneumoniae and bioinformatics preferred.

Responsabilités

• Conduct genome-wide CRISPRi-seq screens and analyze results.
• Develop research questions and collaborate with team.

Connaissances

Microbiology

CRISPRi-seq

Bioinformatics

Flow Cytometry

Data Analysis

English Proficiency

Formation

PhD in Biological Sciences

PhD in Biomedical Sciences

PhD in Biochemistry

PhD in Bioscience Engineering

Description du poste

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The Université catholique de Louvain (UCLouvain) is internationally recognized for research and teaching quality in many different fields of expertise...

Our research group, headed by Prof. Liselot Dewachter, is part of the de Duve Institute (UCLouvain, campus Woluwe, Brussels, Belgium). In our lab, we focus on the major human pathogen Streptococcus pneumoniae. We use genetics, molecular biology, and microscopy to study processes fundamental for S. pneumoniae growth. By doing so, we hope to discover novel ways to kill this important pathogen and help fight the growing problem of antibiotic resistance.

Your project

We are seeking a postdoctoral researcher to work on our ERC-funded project “REalCYCLE”. This project aims to uncover how S. pneumoniae cell cycle processes (e.g., DNA replication, chromosome segregation, cell division) are regulated and coordinated to ensure the bacterium divides exactly once per DNA replication cycle. You will perform genome-wide CRISPRi-seq screens combined with fluorescence-activated cell sorting (FACS) to select mutants of interest and focus on bioinformatic analysis of these screening results. Based on the mutants and analyses, the molecular mechanisms of cell cycle regulation will be elucidated.

You will independently develop your own research questions and ideas while collaborating with other researchers involved in this ERC project (currently, one PhD student and a research assistant).

Your qualifications and skills

You are a microbiologist with a PhD in Biological sciences, Biomedical sciences, Biochemistry, Bioscience engineering, or equivalent. Ideally, you have experience with S. pneumoniae, microscopy, flow cytometry, or bioinformatics/data analysis. You possess a strong record of academic achievement and excellent written and oral proficiency in English.

Ideally, you are considered to be in "international mobility," meaning you have not resided, studied, or worked in Belgium for more than 24 months over the past 3 years before starting the postdoc.

What we offer

Your appointment will be for a minimum of 2 years, with potential extension based on your goals, qualifications, and productivity. The position is funded by an ERC Starting Grant. You are encouraged to apply for additional fellowships.

Interested?

Applicants should send their CV, motivation letter, and contact information for at least one reference to Liselot Dewachter via email: [e-mail]. Candidates selected for an interview will be notified by August 1, 2025.