Post-Doctoral Fellow in ASO brain delivery (H/F)

Servier France; Gif-sur-Yvette; Sur place; EUR 36 000 - 48 000; Plein temps

Résumé du poste

A leading pharmaceutical company in Gif-sur-Yvette is seeking a Post-Doctoral Fellow in ASO brain delivery. The role involves collaborating with a multidisciplinary team to tackle challenges in delivering antisense oligonucleotides across the blood-brain barrier. Ideal candidates should hold a PhD in in-vitro Neurosciences and possess strong in-vitro culture skills. Join us in making a significant impact in the field of neurological diseases.

Prestations

Collaborative environment

Impactful work in groundbreaking research

Qualifications

• Previous post-doc experience in in-vitro neuroscience is a plus.
• Willingness to perform in-vitro/in-vivo experiments.
• Basic knowledge in the ASO field.

Responsabilités

• Collaborating with the chemistry department to deliver optimal constructs.
• Conducting in-vitro evaluations on neurons.
• Coordinating in-vivo evaluations with DMPK, pharmacologists, and toxicologists.
• Supporting data collection and sharing with R&D partners.

Connaissances

Experience in in-vitro culture and cellular microscopy

Fluent in English and French

Strong communication skills

Team spirit

Proactive and result-oriented

Formation

PhD in in-vitro Neurosciences or equivalent

Description du poste

Post-Doctoral Fellow in ASO brain delivery (H/F)

We are a human‑scale, international, and independent pharmaceutical group governed by a Foundation that is committed to therapeutic progress for the benefit of patients.

As a global leader in cardiology, we aim to become a focused and innovative player in oncology by 2030, targeting hard‑to‑treat cancers and dedicating more than 70 % of our R&D budget to this goal.

We are 22 000 passionate individuals from over 50 nationalities, driven by an entrepreneurial spirit. Every day we move forward for patients and for our teams, motivated by the desire to care, to dare, to grow, and to commit to being useful to those in need.

Come and experience and contribute to our commitment #MovedByYou.

Are you passionate about advancing treatments for brain neurological diseases? We are seeking a highly motivated post‑doctoral fellow to join our team and tackle the challenge of delivering antisense oligonucleotides (ASOs) across the blood‑brain barrier (BBB). This project aims to evaluate and validate innovative delivery approaches that ensure high brain specificity for ASOs.

Why Join Us?

• Innovative Research: Delivering ASOs across the BBB remains a major bottleneck in treating brain neurological diseases. While several approaches have been identified, they require further optimisation for clinical application.
• Impactful Work: Contribute to groundbreaking research that has the potential to revolutionise the treatment of neurological diseases.
• Collaborative Environment: Work closely with a multidisciplinary team, including chemists, pharmacologists, toxicologists, and other scientists, to ensure the alignment and integration of research findings.

Responsibilities

• Collaborating with the chemistry department to deliver optimal constructs.
• Conducting in‑vitro evaluations on neurons (training provided if needed).
• Coordinating in‑vivo evaluations with DMPK, pharmacologists, and toxicologists.
• Partnering with internal and external collaborators.
• Staying updated with scientific advancements (literature review, new techniques).
• Supporting data collection and sharing with R&D partners.
• Organising project review meetings, presenting data, and writing reports.
• Communicating results through peer‑reviewed journals and conference presentations.
• Contributing to lab activities, mentoring students, and engaging in science outreach.

Profile

• PhD in in‑vitro Neurosciences or equivalent.
• Previous post‑doc experience in in‑vitro neuroscience is a plus.
• Experience in in‑vitro culture and cellular microscopy.
• Experience in neuronal in‑vitro culture is a plus.
• Willingness to perform in‑vitro/in‑vivo experiments.
• Basic knowledge in the ASO field.
• Knowledge in chemistry and DMPK/Distribution is a plus.
• Fluent in English and French.
• Ability to mentor interns or technicians.
• Team spirit, proactive, and result‑oriented.
• Strong communication skills and experience in writing and publishing in international peer‑reviewed journals.

We are committed to equal opportunities and developing talents in all their diversity. We value both experience and the desire to engage daily in contributing to therapeutic progress for the benefit of patients. If this offer resonates with you, seize this opportunity to meet us!