PhD in cell biology (M/F)

CNRS; France; Sur place; EUR 40 000 - 60 000; Plein temps

Résumé du poste

A leading research organization in France is seeking a PhD student to join a team researching centrioles and cilia. The role involves characterizing a specific connector in cells and investigating its molecular architecture and functions. Candidates must possess a Master's degree in cell biology and expertise in super-resolution microscopy. This unique position offers an opportunity to contribute to significant developmental biology research.

Qualifications

• Expertise in super-resolution microscopy techniques.
• Proficiency in molecular biology methods including CRISPR/Cas9 and RNAi.
• Strong background in cell biology.

Responsabilités

• Characterise the connector between centrioles in cells with a primary cilium.
• Determine the molecular architecture and mechanisms regulating assembly.
• Investigate the function in developmental processes using zebrafish.

Connaissances

Expertise in super-resolution microscopy

CRISPR/Cas9

RNAi

Formation

Master's degree in cell biology

Description du poste

Organisation/Company CNRS Department Institut Jacques Monod Research Field Biological sciences Biological sciences » Biology Researcher Profile First Stage Researcher (R1) Country France Application Deadline 28 Nov 2025 - 23:59 (UTC) Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 1 Feb 2026 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The PhD student will be a member of the 'Biogenesis and polarity of centrioles and cilia' team led by Juliette Azimzadeh at the Jacques Monod Institute (UMR7592 Université Paris Cité – CNRS). The team uses cellular biology approaches, in particular super-resolution microscopy. The Institut Jacques Monod is a joint research unit of Université Paris Cité and CNRS with approximately 300 staff members. The institute is located on the Paris Rive Gauche campus in the 13th arrondissement of Paris.

The thesis project aims to characterise a connector between the two centrioles of the centrosome that forms specifically in cells with a primary cilium, enabling the centrioles to be positioned correctly in these cells. The objective of the project is to determine the molecular architecture of the connector and the mechanisms that regulate its assembly, and to identify its functions. This will involve the use of expansion microscopy in combination with other super-resolution microscopy approaches such as STED, and molecular biology approaches (CRISPR/Cas9, RNAi), in a human cell culture model. The function of this structure in developmental processes will also be addressed in zebrafish as part of a collaboration. The candidate must have a Master's degree in cell biology and expertise in super-resolution microscopy.