Research Specialist A

Perelman School of Medicine at the University of Pennsylvania; Kirkkonummi; On-site; EUR 38,969 - 47,070; Full time

Benefits offered by this job

Health benefits

Tuition assistance

Paid time off

Retirement plans

Job summary

The Research Specialist A at Perelman School of Medicine at the University of Pennsylvania will work on developing and testing nanotechnologies for the treatment of acute brain illnesses, including stroke. The role includes creating nanoscale carriers and targeting them to organ and cell types in mouse models and ex vivo human organs, with industry collaboration opportunities.

You will perform a broad range of experiments in mouse work, molecular biology, pharmacology, and biodistribution,

Qualifications

• Bachelor of Science and 0 to 1 year of experience or equivalent combination of education and experience is required.
• 0–3 years experience in biology, biochemistry, molecular biology, pharmacology or related fields.
• Preference for experience with mouse work, including minor surgeries and tissue collection.

Responsibilities

• Perform a broad range of experiments in mouse work, molecular and cell biology, and pharmacology.
• Conduct mouse models of disease, organ harvest, histology, and flow cytometry.
• Carry out pharmacological biodistribution experiments by injecting mice and harvesting organs.
• Produce nanoscale drug carriers per established protocols and perform data analysis.

Skills

Biology

Cell biology

Biochemistry

Molecular biology

Pharmacology

Chemistry

Chemical engineering

Bioengineering

Mouse work

Education

Bachelor of Science

Job description

Job Title

Research Specialist A

Job Description Summary

The Research Specialist A position will work on developing and testing nanotechnologies for the treatment of acute brain illnesses, such as ischemic and hemorrhagic stroke. As outlined on our parent lab’s website www.brennerbioengineeringlab.com, our lab packages drugs and gene therapy vectors into nano-scale carriers (~100 nanometers in diameter), and targets them to the organ and cell types of interest using affinity moieties (e.g., antibodies), cell‑hitchhiking, and medical devices. We test these in mouse models of acute critical illness, as well as large animal models, and in ex‑vivo human organs. We often partner with existing companies and spin out our own start‑ups, giving the opportunity to gain experience interacting with industry.

Job Description

The applicant will perform a broad range of experiments in mouse work, molecular and cell biology, and pharmacology. The methods will include mouse models of disease followed by organ harvest; histology of mouse organs; flow cytometry of dissociated mouse organs; pharmacological biodistribution experiments (injecting mice with drugs and harvesting organs to determine drug distribution); production of nanoscale drug carriers according to protocols we already have well worked out; behavioral tests to screen for therapeutic outcomes. The Principal Investigator will design experiments with the applicant, but the applicant will be expected to troubleshoot these procedures as needed. The applicant will also keep accurate notebooks, perform data analysis, and assist in publication preparation. Additional duties will include assisting in experimental design, and participating in general laboratory activities such as lab meetings, ordering, and maintenance.

Qualifications

• Bachelor of Science and 0 to 1 year of experience or equivalent combination of education and experience is required.
• 0‑3 years experience in one of the following fields: biology, cell biology, biochemistry, molecular biology, pharmacology, chemistry, chemical engineering, bioengineering, or other related fields.
• It is preferable for the applicant to have experience with mouse work, including minor surgeries and collection of tissues.
• Additional training will be provided as needed, including teaching of the unique aspects of nanomedicine.

Job Location

Philadelphia, Pennsylvania

Department / School

Perelman School of Medicine

Pay Range

$44,500.00 - $53,750.00 Annual Rate

Equal Opportunity Statement

The University of Pennsylvania is an equal opportunity employer. Candidates are considered for employment without regard to race, color, sex, sexual orientation, religion, creed, national origin (including shared ancestry or ethnic characteristics), citizenship status, age, disability, veteran status or any class protected under applicable federal, state or local law.

Special Requirements

Background checks may be required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.

Benefits

The University offers comprehensive benefits, including health, life, and flexible spending accounts; tuition assistance; generous retirement plans; paid time off; long‑term care insurance; wellness and work‑life resources; and professional development opportunities. For detailed information, please visit https://www.hr.upenn.edu/PennHR/benefits-pay.