Principal Scientist, Biophysics/Biochemical DMTL Automation

7300-Janssen-Cilag S.A. Legal Entity; Toledo; Sur place; EUR 64 000 - 109 000; Plein temps

Avantages offerts par ce poste

Annual bonus

Vacation days

Parental leave

Bereavement leave

Well-being reimbursement

Insurance plans

Résumé du poste

Johnson & Johnson in Toledo, Spain, seeks an innovative Principal Scientist to advance biophysical and biochemical capabilities. Based in Toledo, you will develop SPR and biochemical assays, automate workflows, and collaborate across DTMP to accelerate DMTL cycles. Lead interpretation of complex datasets to guide hit-to-lead decisions.

You will contribute to rapid discovery programs, integrate across platform teams, and drive scientific leadership in a highly collaborative environment.

Qualifications

• Ph.D. in Biophysics, Biochemistry, Structural Biology, or a related scientific discipline.
• 8+ years of experience developing and executing biophysical and biochemical assays in pharma/biotech/academia.
• Hands-on expertise with SPR and biochemical techniques with robust binding & kinetics interpretation.
• Experience with assay automation, high-throughput experimentation, or robotics.
• Ability to translate complex data into actionable drug-discovery decisions.

Responsabilités

• Design, develop, and execute SPR and biochemical assays for hit validation and lead optimization.
• Generate and interpret kinetic and thermodynamic data to guide DMTA decisions.
• Develop automated workflows to scale discovery assays and data generation.
• Lead cross-functional teams across chemistry, biology, automation, and data science.
• Present data-driven findings to project teams and senior stakeholders.

Connaissances

Biophysical assay development

Data interpretation

Cross-functional collaboration

Technical leadership

Kinetic analysis

Protein-ligand interactions

Scientific communication

SAR understanding

DMTA knowledge

Formation

Ph.D. in Biophysics, Biochemistry, Structural Biology, or related discipline

Outils

SPR

Biophysical platforms

Automation

Laboratory robotics

Description du poste

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.Learn more at jnj.com.

Job Function: Discovery & Pre-Clinical/Clinical Development

Job Sub Function: Biological Research

Job Category: Scientific/Technology

All Job Posting Locations: Toledo, Spain

Job Description: Principal Scientist, Biophysics/Biochemical DMTL Automation

Location: Toledo, Spain

Level: Principal Scientist (ST7)

Role Overview:

We are seeking an innovative, highly collaborative, and self-directed Principal Scientist to advance next-generation biophysical and biochemical capabilities supporting Design-Make-Test-Learn (DMTL) workflows across Discovery within Discovery Technologies and Molecular Pharmacology (DTMP). Based in Toledo, Spain, this role will generate and interpret high-quality Surface Plasmon Resonance (SPR) and biochemical data to guide decisions from hit identification through lead optimization. The successful candidate will develop innovative assays, implement automated workflows, and partner across chemistry, biology, computational sciences, automation, and platform teams to accelerate DMTA cycles and strengthen the speed, quality, and predictability of discovery.

Key Responsibilities:

• Biophysical and Biochemical Assay Development & Discovery Support
  • Design, develop, and execute SPR and biochemical assays to support hit validation and lead optimization across discovery programs
  • Generate and interpret kinetic, affinity, thermodynamic, and biochemistry data to guide SAR and critical project decisions DMTA
• Acceleration & Data Generation
  • Deliver high-quality biophysical and biochemistry data that accelerates DMTL cycles and enables rapid, data-driven discovery decisions
  • Develop robust and scalable experimental workflows that expand throughput and reproducibility across the portfolio
• Technology Innovation & Automation
  • Drive the development and implementation of automated biophysical and biochemical lab design and workflows that increase experimental scale, consistency, and scientific impact
  • Partner with automation, informatics, engineering, and platform teams across teams to integrate biophysical and biochemical capabilities into scalable DMTA workflows and next‑generation discovery platforms
• Scientific Collaboration & Technical Leadership
  • Act as an independent scientist, identifying opportunities, solving complex technical challenges, and leading cross‑functional Discovery project teams to shape biophysical and biochemical strategies that advance project objectives
  • Collaborate across chemistry, biology, computational sciences, structural biology, automation, and data science within Global Discovery Chemistry (GDC) and DTMP to translate biophysical and biochemical insights into portfolio decisions

Qualifications Education

• Ph.D. in Biophysics, Biochemistry, Structural Biology, or a related scientific discipline

Required Experience & Skills

• 8+ years of experience developing and executing biophysical and biochemical assays in a pharmaceutical, biotechnology, or academic research environment
• Demonstrated hands‑on expertise with SPR, complementary biophysical platforms, and biochemical techniques
• Demonstrated ability to determine robust binding affinities and kinetic parameters, supported by appropriate experimental controls, replicates, error analysis, and scientific interpretation
• Experience with assay automation, high‑throughput experimentation, or laboratory robotics
• Strong understanding of protein‑ligand interactions, kinetics, thermodynamics, and molecular mechanisms
• Demonstrated expertise in assay development, optimization, troubleshooting, data analysis, and curve fitting, beyond execution of established protocols
• Ability to interpret complex biophysical and biochemical datasets and translate results into actionable drug discovery decisions
• Strong scientific communication and collaborative problem‑solving skills, including the ability to present and defend data to multidisciplinary project teams

Preferred Experience

• Experience supporting Design‑Make‑Test‑Learn (DMTL) workflows
• Familiarity with computational chemistry, structural biology, or AI‑enabled drug discovery approaches
• Experience working in multidisciplinary teams spanning chemistry, biology, automation, and data sciences

Non‑Technical Skills

• Scientific curiosity, innovation mindset, and strong experimental judgment
• Critical thinking with the ability to translate complex data into clear, actionable scientific insights
• Collaborative, self‑directed, and effective in fast‑paced, highly matrixed environments

Required Skills: Preferred Skills:

• Big Data Management
• Critical Thinking
• Data Reporting
• Data Savvy
• Drug Discovery Development
• Molecular Diagnostics
• Organizing
• Pharmaceutical Microbiology
• Problem Solving
• Product Knowledge
• Project Reporting
• Project Schedule
• Research Proposals
• Scientific Research
• Standard Operating Procedure (SOP)
• Standard Scientific Processes and Procedures
• Strategic Thinking
• Sustainability

The anticipated base pay range for this position is: €63 700,00 - €109 480,00

Benefits:

• an annual bonus with set target (% of pay) depending on pay grade / location, where the actual amount is based on the employees’ and companies’ performance of the previous calendar year, or sales commissions.
• Moreover, we offer vacation days, parental leave for a minimum of 12 weeks, bereavement leave, caregiver leave, volunteer leave, well‑being reimbursement, programs for financial, physical and mental health.
• We also offer service anniversary and recognition awards, and subject to the terms of their respective plans, employees - and in some location’s eligible dependents - can participate in several insurance plans.
• *This is for informative purposes only. Amounts and actual benefits may vary by location and are subject to change.

Our Credo calls on us to respect the dignity of every individual and create an environment for all people to thrive. Throughout the recruitment process - from application through hiring - we are committed to providing reasonable accommodations/adjustments for qualified candidates with disabilities. If you need support at any stage of the recruitment process, please complete our candidate accommodation request form so we can assist you.

Do Not Sell or Share My Personal Information Limit the Use of My Personal Information