Postdoctoral Fellow (Ref. PD/26/11)

IRB Barcelona; Barcelona; Presencial; EUR 35.000 - 45.000; Jornada completa

Ventajas ofrecidas por este puesto de trabajo

Relocation & Visa Assistance

International environment

Career development opportunities

Social and cultural activities

Descripción de la vacante

IRB Barcelona, a renowned biomedical research centre in Barcelona, seeks a Postdoctoral Fellow to study Crosstalk analysis of MAPK signaling within the Cell Signaling Research Group. You will work on signaling dynamics, kinase activity in single cells, and biochemical characterization of MAPK components using MS and phosphomutant analyses.

The role involves independent hypothesis testing, collaboration with a multidisciplinary team, and contributions to scientific publications and reports in a

Formación

• PhD in Life Sciences required.
• Experience in cell signaling research, preferably kinase pathways.
• Hands-on mass spectrometry-based phosphoproteomics or phosphopeptide analysis.
• Experience with confocal microscopy and image analysis.
• Strong peer reviewed publication record.
• Ability to design and conduct experiments independently.
• Excellent communication and collaboration skills.

Responsabilidades

• Study intracellular signaling dynamics using in vitro and in vivo assays.
• Analyze kinase activity in single cells by microscopy.
• Biochemical characterization of MAPK pathway components using mass spectrometry and phosphomutant analyses.
• Investigate cell-type-specific responses to MAPK activation in cellular models.
• Assess cell viability, cell cycle progression, and stress responses.
• Independently design and test biological hypotheses.
• Plan, perform and interpret experiments.
• Collaborate with a multidisciplinary team.
• Contribute to lab protocols and sharing of resources.
• Prepare scientific communications and participate in discussions.

Conocimientos

Cell signaling research

Mass spectrometry

Confocal microscopy

Phosphoproteomics

Mammalian cell culture

Scientific writing

Independent experimentation

English proficiency

Team collaboration

Multitasking

Educación

PhD in Life Sciences

Descripción del empleo

Your Role & Our Team

IRB Barcelona is seeking a highly motivated and talented Postdoctoral Fellow to participate in cutting edge research line -Crosstalk analysis of MAPK signaling- of the Cell Signaling Research Group led by Dr. Francesc Posas and Dr. Eulàlia de Nadal.

KEY RESPONSIBILITIES

• Studying intracellular signaling dynamics using in vitro and in vivo assays.

• Studying kinase activity in single cells by microscopy.

• Biochemical characterization of MAPK pathway components and phosphorylation events using mass spectrometry and phosphomutant analyses.

• Investigating cell-type-specific responses to MAPK pathway activation using multiple cellular models.

• Assessing cell viability, cell cycle progression, and stress adaptation in response to pathway perturbations.

• Independently design and test biological hypotheses.

• Plan, perform and interpret experiments.

• Collaborate with a multidisciplinary research team, tapping into the expertise of fellow researchers and external collaborators.

• Contribute to a culture of scientific excellence, efficiency, and teamwork.

• Contribute to other lab projects and to the maintenance of protocols and laboratory resources in the group.

• Critically analyze analytical results, participate in scientific discussions and in preparation of diverse forms of scientific communication (seminars and conferences).

• Participate in the project activities: meetings, presentations, visits to other labs, collaboration, exchange of data sets, preparing project reports/deliverables.

• Writing scientific articles and research projects.

• Perform excellent research according to the high standards of the lab and the IRB Barcelona.

YOU HAVE

• PhD in any of the Life Sciences fields.

• Experience in cell signaling research, preferably in kinase-based pathways.

• Hands‑on experience with mass spectrometry‑based phosphoproteomics or familiarity with phosphopeptide analysis.

• Demonstrated experience in confocal microscopy and image analysis.

• Extended knowledge in culture of mammalian cells, molecular and cell biology techniques.

• Strong peer reviewed publication record

• Demonstrated ability to design and conduct experiments independently.

• Excellent communication skills and the ability to collaborate effectively.

• Strong organizational and multitasking skills.

• Attention to detail and accuracy.

• Proficiency in English (both written and spoken).

• Highly motivated, enthusiastic and collaborative person.

• Willing to keep on learning.

• Ability to work independently in a demanding research environment.

YOU MIGHT ALSO HAVE

• Experience with phosphomutant generation and functional validation.

• Knowledge of stress response pathways (osmotic stress, oxidative stress, DNA damage) and their interplay.

• Experience working with mouse models relevant to stress signaling or stem cell biology. and relevant certifications or a certificate of competence for handling animals for experimentation.

• Research experience in signal transduction.

• Familiarity with bioinformatic tools for single‑cell data analysis or mass spectrometry data processing.

• Experience in university‑level teaching or supervision of junior researchers (undergraduate or Master’s students).

WHAT WE OFFER

To be a part a part of something meaningful: We are a biomedical research centre that tirelessly works to achieve a society free of diseases. Our mission is to carry out research of excellence to cure cancer and other diseases linked to ageing.

Good Working conditions:2-3 years Postdoctoral Fellow. Employed in compliance with Spanish legislation and regulations under a full‑time contract. Employees receive the benefits of the Spanish Social Security system covering sickness, maternity/paternity leave and injuries at work.

Competitive salary:commensurate with experience and qualifications.

International Environment:Nearly 90 Postdoctoral researchers (more than a half non‑Spanish nationals) are currently working at IRB Barcelona.

Multidisciplinary Research:Research of excellence at the unique interface between biology, chemistry, and structural and computational biology.

Training and Career:Postdoctoral researchers joining IRB Barcelona gain access to the Institute’s advanced research training and career development opportunities, all within in a competitive international environment. Courses and workshops on themes of particular interest to postdocs are offered regularly by the Institute.

Relocation & Visa Assistance:Trained staff provides support on visa paperwork, administrative requirements, and practical information on living and working in Barcelona, etc.

Social Life:We like to have fun. We promote several activities, like a Football League, an annual skiing trip, a Mountaineering Club, a Running Club and "Cool-off sessions", where members meet informally for drinks, snacks and scientific discussions.

Fairness:Our recruitment is open, transparent and merit‑based, and all applicants compete on the same terms. We are an Equal Opportunity Employer and all qualified applicants are considered for employment without regard to race, colour, religion, age, sex, sexual orientation, gender identity, nationality, ethnic origin or disability.

IRB BARCELONA endorses the Requirements and Principles of the European Charter for Researchers, the Code of Conduct for the Recruitment of Researchers, and Open, Transparent, Merit‑based recruitment promoted by the European Commission and follows Equal Opportunities policies.

On 9 December, 2014, IRB Barcelona was awarded the "HR Excellence in Research" logo. This recognition reflects the commitment of the Institute to the continuous improvement of its human resources policies in line with the Charter & Code. The Institute works to ensure fair and transparent recruitment and appraisal procedures.

Please check our Recruitment Policy.

Note: The strengths and weaknesses of the applications will be provided upon request.

ABOUT IRB BARCELONA,

Created in 2005 by the Generalitat de Catalunya (Government of Catalonia) and the University of Barcelona, IRB Barcelona is a Severo Ochoa Centre of Excellence—a seal that was awarded in 2011.

The institute is devoted to conducting research of excellence in biomedicine and to transferring results to clinical practice, thus improving people’s quality of life, while simultaneously promoting the training of outstanding researchers, technology transfer, and public communication of science. Its 27 laboratories and 9 core facilities address basic questions in biology and are orientated to diseases such as cancer, metastasis, Alzheimer’s, diabetes, and rare conditions.

IRB Barcelona is an international centre that hosts 500 members and 45 nationalities. It is located in the Barcelona Science Park. IRB Barcelona forms part of the Barcelona Institute of Science and Technology (BIST) and the “Xarxa de Centres de Recerca de Catalunya” (CERCA).