Senior Upstream Laboratory Technician/Laborant, for Early-Stage Development at AGC Biologics

AGC Biologics A/S; København; On-site; DKK 650,000 - 850,000; Full time

Job summary

AGC Biologics A/S in Søborg, Denmark, is seeking a Senior Upstream Laboratory Technician to culture mammalian cells from shake flasks to pilot-scale bioreactors and support GMP cell-bank production.

You will generate high-quality data, keep timelines on track, and contribute to continuous process improvements in a dynamic, project-driven environment. A collaborative team of technicians and scientists awaits you.

Qualifications

• Hands-on mammalian cell culture experience in an industrial, CDMO or academic setting.
• Experience with bioreactor operation and aseptic technique (cGMP).
• Good English skills, spoken and written, and proficiency with MS Office / data systems.

Responsibilities

• Seed train and production runs in shake flasks and pilot-scale bioreactors.
• Perform routine sampling and monitor in-process parameters (viability, pH, metabolites).
• Prepare media/feeds and assist GMP cell bank production.
• Document experiments accurately in ELN and batch records.
• Maintain SOPs and perform daily maintenance of upstream equipment.

Skills

Mammalian cell culture

Bioreactor operation

GMP experience

English communication

Education

Laboratory technician background or equivalent

Tools

ELN

MS Office / data systems

Bioreactors

Job description

*For the English version, please scroll down*

Arbejdssted: Søborg, Danmark. Bemærk, at AGC Biologics ikke tilbyder hjælp i forbindelse med flytning. Ansøgere skal allerede være bosat i Danmark.

Location: Søborg, Denmark. Please note that AGC Biologics does not offer relocation assistance. Applicants must already reside in Denmark.

AFDELINGEN OG TEAMET

Early-Stage Process Development afdelingen (ESD) spiller en afgørende rolle i at bringe nye lægemidler fra koncept til patient, med projekter der spænder fra tidlig præklinisk udvikling til kliniske studier. Afdelingen er ansvarlig for cellelinjeudvikling, tidlig procesudvikling og fremstilling af cellebanker. Afdelingen består af tre tværfaglige teams, hvor upstream-, downstream- og analytiske eksperter arbejder sammen for at nå projektmålene. Du vil blive en del af en gruppe af højt dedikerede laboranter og scientists, der samarbejder om udvikling og optimering af processer. Teamene driver projekterne, og du vil opleve tæt samarbejde inden for teamet mellem forskellige tekniske discipliner. Vi udvikler processer for produkter produceret i både mammale og mikrobielle cellelinjer og samarbejder med forskellige interessenter såsom Analytical Method Development og Manufacturing. Du vil opleve en dynamisk og fleksibel arbejdsplads med mange muligheder for både at bidrage og udvikle dig.

ROLLEN

Som senior Upstream Laborant vil du udføre cellekultivering i rystekolber og hele vejen op til pilot bioreaktorer samt understøtte GMP cellebankproduktion. Du vil generere data af høj kvalitet, holde tidsplaner på sporet og bidrage til løbende procesforbedringer i et dynamisk, projektorienteret miljø. Du vil arbejde sammen med et team af 6 laboranter og 7 scientists inden for teamet og på tværs af teams i hele afdelingen. Vi kan love dig et spændende og varieret job. Arbejdsmiljøet i vores afdeling er meget uformelt. Der er konstant samarbejde på tværs af organisationen, og alle medarbejdere har en professionel og fleksibel tilgang til deres arbejde.

ANSVARSOMRÅDER

• Seed train og produktionskørsler i rystekolber, CultiBags, 5 L glasbioreaktorer, AMBR-250 og pilot-skala bioreaktorer.
• Rutinemæssig prøvetagning for at monitorere forskellige procesparametre, herunder VCD og viabilitet (Cedex og Vi-CELL), pH, metabolitter og gasser (FLEX2).
• Fremstilling af medier og feeds.
• Assistere i GMP cellebankproduktion og karakterisering.
• Forberedelse af høst og prøvehåndtering til Downstream/Analytics.
• Dokumentation i ELN og papirbaserede batch records.
• Forberedelse og opdatering af SOP'er.
• Daglig vedligeholdelse, kalibrering og fejlfinding af upstream-udstyr.

DIN PROFIL

Vi søger en senior laborant med baggrund og interesse for cellekultivering. Den ideelle kandidat er uddannet laborant eller har en tilsvarende videnskabelig/teknisk baggrund. Vi forventer desuden, at du har:

• Praktisk erfaring med mammal cellekultur i en industriel, CDMO eller akademisk kontekst.
• Erfaring med bioreaktoroperation og aseptisk teknik cGMP-erfaring.
• Gode engelskkundskaber (tale og skrift) samt erfaring med MS Office/data systemer.
• Som person er du en holdspiller med en positiv indstilling og en fleksibel kollega. Du arbejder effektivt i et team og nyder at tage ansvar samt udføre opgaver selvstændigt.

THE DEPARTMENT AND TEAM

The Early-Stage Process Development Department (ESD) plays a crucial role in bringing new drugs from concepts to patients, with projects ranging from early pre-clinical development through clinical studies. The department is responsible for cell line development, early-stage process development, and cell bank manufacturing. The department is composed by three interdisciplinary teams, where upstream, downstream and analytical experts work together to achieve the project goals. You will be part of a group of highly dedicated laboratory technicians and scientists collaborating on development and optimization of processes. The teams are driving the projects, and you will experience close collaboration within the team between different technical disciplines. We develop processes for products produced in both mammalian and microbial cell lines and collaborate with various stakeholders such as Analytical Method Development and Manufacturing. You will experience a dynamic and flexible working place with many opportunities to both contribute and develop.

THE ROLE

As a Senior Upstream Laboratory Technician you will perform mammalian cell cultivation from shake flask to pilot-scale bioreactor and support GMP cell-bank creation. You will generate high-quality data, keep timelines on track and contribute to continual process improvements in a dynamic, project-driven environment. You will be working together with a team of 6 laboratory technicians and 7 scientists within the team and across teams in the whole department. We can promise an exciting and diverse job. The work environment in our department is very informal. There is constant collaboration across the organization, and all employees have a professional and flexible attitude towards their work.

RESPONSIBILITIES

• Seed train and production runs in shake flasks, single-use CultiBags, 5L glass vessels, AMBR-250, and pilot-scale bioreactors
• Routine sampling to monitor various in-process parameters, including cell density and viability (Cedex and Vi-CELL), pH, metabolites, and gassing (FLEX2)
• Preparation of media and feeds
• Assist in GMP cell bank manufacturing and characterization
• Harvest preparation, and sample logistics to Downstream/Analytics
• Accurate documentation in ELN and paper-based batch records
• Preparation and update of SOPs
• Daily maintenance, calibration and troubleshooting of upstream equipment.

YOUR PROFILE

• We are looking for a senior laboratory technician with a background and an interest in cell culturing. The ideal candidate is an educated lab technician or has an equivalent scientific/technical background.
• Furthermore, we expect you to have: Hands-on mammalian cell culture in an industrial, CDMO or academic setting
• Experience with bioreactor operation and aseptic technique cGMP experience
• Good English skills (spoken & written) and proficiency with MS Office / data systems.
• As a person, you are a team player with a positive attitude and a flexible colleague. You work efficiently in a team and enjoy assuming responsibility as well as performing tasks independently.

Who We Are

AGC Biologics is a global Contract Development and Manufacturing Organization with a strong presence in Denmark. From our Søborg site, we develop and manufacture life‑changing advanced biologics for some of the world’s most innovative pharmaceutical companies. Together with our team members across Europe, the U.S., and Japan, we deliver development and manufacturing of mammalian and microbial-based therapeutic proteins, plasmid DNA (pDNA), messenger RNA (mRNA), viral vectors, and genetically engineered cells therapies. Across our global network, we are united by one mission: To work side by side with our customers in order to improve patients’ lives by bringing new biopharmaceuticals to market. AGC Biologics is Your Friendly CDMO Expert – dedicated partners with the expertise and commitment to support our customers and teams. We work with some of the world’s most innovative pharmaceutical companies to develop and manufacture their life-changing drug products. If you’re motivated by meaningful impact and ready to join our journey, we invite you to explore our current opportunities!