Postdoc in Metabolic Engineering of Thermofiles - BRIGHT

DTU; Kongens Lyngby; Remote; DKK 420,000 - 540,000; Full time

Job summary

DTU, in collaboration with BRiGHT, invites applications for a role to design and develop microbial production systems for biochemicals. You will engineer thermophilic bacteria, develop molecular biology tools, and perform fed-batch fermentation as part of a multi-group project advancing sustainable bioprocesses.

The appointment is two years, starting Jan 1, 2027, under a Danish collective agreement. Candidates should hold a PhD in microbiology or related field, with strong background in

Qualifications

• PhD with strong background in microbiology, fermentation technologies and metabolic engineering.
• Demonstrated experience with metabolic engineering of thermophilic organisms for production of biochemicals.
• Experience with molecular biology tools and engineering approaches for gram positive bacteria.

Responsibilities

• Metabolic engineering of thermophilic bacteria using state of the art synthetic biology tools.
• Develop and improve molecular biology tools for thermophilic bacteria.
• Test engineered strains by fed batch fermentation.
• Carry out evolution experiments to optimize strain performance.
• Collaborate with an interdisciplinary team of researchers and supervise student projects.
• Publish research findings in high-impact journals and contribute to project deliverables.

Skills

Metabolic engineering

Molecular biology

Thermophilic bacteria

Education

PhD in microbiology or related field

Tools

Synthetic biology tools

Fermentation

Job description

Are you passionate about sustainabilityandreducing environmentalimpact through biomanufacturing? Then come join usin advancing technologies for developing robust microbial cell factoriesandscalable bioprocesses that convert CO₂-derived feedstocksinto high-volume chemicals. This multi-yearinitiative consists of joint efforts between multiple groups covering the entireinnovation pipeline, from metabolic toolsand design, strain engineering, process design, fermentation, downstream processing, multi-omics, techno-economic validation,andbusiness development. We aim to establish newindustrial routes for essential chemicalsin a low-carbon economy throughinterdisciplinary collaboration.

You will play a key role in a project coordinated by Professor Alex Toftgaard Nielsen at BRiGHT (Novo Nordisk Foundation Biotechnology Research Institute for the Green Transition) at the Technical University of Denmark.

You will be involved in designing and developing novel microbial systems for metabolising selected chemical substrates for production of biochemicals. The goal is to develop microbial production systems that radically change the production of chemicals in our society.

Responsibilities

• Metabolic engineering of thermophilic bacteria using state of the art synthetic biology tools.
• Contribute to developing and improving molecular biology tools for thermophilic bacteria.
• Test the engineered strains by fed batch fermentation.
• Carry out evolution experiments to optimize strain performance
• Contribute to teaching and supervising BSc and MSc student projects.
• Collaborate with an interdisciplinary team of researchers.
• Contribute to publishing research findings in high-impact scientific journals.
• Prepare presentations, as well as project deliverables ensuring high levels of accuracy and presentation.

Qualifications

As a formal qualification, you must hold a PhD degree (or equivalent). We are looking for a candidate with a strong demonstrated background in general microbiology, fermentation technologies, and metabolic engineering, ideally combined with:

• In-depth knowledge of molecular and synthetic biology.
• Demonstrated experience with metabolic engineering of thermophilic organisms for production of biochemicals.
• Experience with engineering tools for gram positive bacteria.
• Experience with adaptive laboratory-based evolution.
• Excellent communication skills and an openness to interdisciplinary teamwork.

Solid English capabilities are required, and you will be involved in teaching and supervision of BSc and MSc student projects.

We offer

DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and terms of employment

The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. In addition, supplements can be negotiated in accordance with DTU’s salary structure for scientific staff: www.inside.dtu.dk/en/human-resources/during-employment/salary/salary-structures. The period of employment is two years. Start date is 1 January 2027 or according to mutual agreement.

You can read more about career paths at DTU here.

Further information

Further information may be obtained from Professor Alex Toftgaard Nielsen, [e-mail]. You can read more about us at www.bright.dk. If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark.

All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply. As DTU works with research in critical technology, which is subject to special rules for security and export control, open-source background checks may be conducted on qualified candidates for the position.

The Novo Nordisk Foundation Biotechnology Research Institute for the Green Transition (BRiGHT) at DTU. Recent progress in our ability to read and write genomic code, combined with advances in automation, analytics and data science, has fundamentally changed the scope and ambition of harnessing the potential of biological systems. Big data approaches and analysis of biological systems are key research instruments at the Institute. BRiGHT utilizes these advances for mission driven microbial cell factory design to foster sustainable lifestyles in relation to three application areas: Sustainable materials, Microbial Foods, and Net-zero agriculture.

DTU – For the benefit of society since 1829. DTU is one of Europe's leading elite technical universities. Through research and education at an international top level, we create solutions to the major societal challenges of our time and help secure Europe's global leadership in sustainable technological development. Since Hans Christian Ørsted founded DTU almost 200 years ago, our mission has remained the same: We develop and create value through the natural and technical sciences for the benefit of society. DTU has 13,800 students, 1,600 PhD students, and 6,500 employees. We work in an international environment and have an inclusive, stimulating, and informal work culture. DTU has campuses in all parts of Denmark and in Greenland and collaborates with the best universities around the world.