FMI - Novartis Biomedical Research Postdoctoral Position in Studying the Regenerative Potential[...]

at the Friedrich Miescher Institute for Biomedical Research (FMI) investigates the collective properties and patterning of multicellular systems. Their research focuses on how such properties arise from single-cell behavior and their self-organization, in order to elucidate fundamental biological processes.

The Disease of Aging and Regenerative Medicine (DARe) Department at Novartis is focused on elucidating and targeting the molecular mechanisms underlying diseases of aging, with the goal of developing regenerative pharmacological therapies that restore tissue integrity and function. Within DARe, the lab of Christine Halleux is part of a team aiming to understand salivary gland epithelial cell regeneration to treat Sjögren’s Disease (SjD) xerostomia.

SjD is a chronic autoimmune disorder that severely affects patients' quality of life, leading to symptoms such as profound fatigue, pain, and dryness of mucosal surfaces caused by dysfunction or destruction of exocrine glands. Currently, no approved therapies exist for SjD. However, B cell depletion using the anti-BAFFR antibody ianalumab has shown clinical efficacy. The observed improvement in salivary gland function suggests a pathogenic interaction between B cells and salivary gland epithelial cells. Enhancing the regeneration of acinar cells, the main secretory units of salivary glands, may offer a complementary or alternative approach to immune-targeted therapies. To pursue this goal, it is essential to dissect the epithelial–immune crosstalk in human salivary glands. A key step toward this is the development of an advanced, translational human salivary gland organoid system that incorporates immune components to model the complex cellular interactions underlying SjD.

We are seeking a highly motivated postdoctoral researcher to develop a human translational complex salivary gland in vitro organoid system with immune component to study the regenerative potential of salivary gland epithelial cells in SjD.

In this role you will :

• Conduct research to develop a validated, reproducible translational in vitro model of human salivary gland that includes epithelial and immune components relevant to SjD pathology.
• Design and execute experiments to generate a comprehensive single-cell and high-content imaging datasets detailing epithelial differentiation and immune interactions under healthy and SjD inflammatory conditions, epithelial plasticity and potential for regeneration.
• Collaborate with cross-functional teams, including experts in organoid models, high-content imaging, single-cell technologies and drug discovery both at FMI and Novartis.
• Enable team success with a curious, proactive, enthusiastic and collaborative spirit.
• Present research findings at internal and external meetings and contribute to high-impact publications.

About you

• You hold a PhD in molecular biology, biochemistry, chemical biology, cell biology or a related field with expertise in 3D organoid culture and tissue engineering.
• You have experience with single-cell transcriptomics or high-content imaging, skills in molecular and cellular biology, including CRISPR, and possible background in immunology, with a focus on immune-epithelial interactions is an advantage.
• You are able to work independently as well as in a matrixed, interdisciplinary environment and incorporate information from global teams working on regenerative medicine and immunology.
• You possess a strong publication record or other scientific achievements (i.e. awards, patents, grants).
• You have excellent analytical, communication and organizational skills.

What we offer

• A three-year postdoc contract with a competitive compensation and benefit package.
• Access to state-of-the-art facilities in high-content imaging, genomics, proteomics, and more.
• Primary location in a Novartis lab in the Disease of Aging and Regenerative Medicine Department (DARe), with access to FMI facilities and daily interactions with both FMI and Novartis researcher teams.
• Opportunities to participate in workshops and training sessions to learn new techniques.
• A vibrant, international, and multidisciplinary environment that strives to be inclusive to people from diverse backgrounds.

How to apply

Please submityour application online atwww.fmi.ch / opening. Your application should include :

• Your CV
• The names and contact details of 3 referees

Applications will be reviewed on a rolling basis until the position is filled. For further information, please contact Prof. Prisca Liberali (prisca.liberali@fmi.ch) or Dr. Christine Halleux (christine.halleux@novartis.com).

About the FMI

The FMI is a world-class biomedical research institute affiliated with the University of Basel and Novartis Biomedical Research. With an international staff of about 330 people, including more than 150 postdoctoral fellows and graduate students, the FMI conducts cutting-edge research in genome regulation, multicellular systems and neurobiology. We are located in the vibrant city of Basel, Switzerland’s third-largest city and Europe’s leading hub for the life sciences.

At the FMI, diversity is the cornerstone of innovation and collaboration. We foster an inclusive environment where everyone can thrive and contribute meaningfully. We welcome applicants of all genders, cultures, ethnicities, and demographics who can complement our existing team. Join us in building a scientific community that represents and benefits the world we study.

www.fmi.ch

About Novartis

Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together?

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