(Senior) Research Associate/(Senior) Scientist, High throughput Proteomics in Targeted Protein Degradation

Serac Biosciences; Basel; Vor Ort; CHF 90.000 - 150.000; Vollzeit

Benefits dieser Stelle

Commuter benefits

Flexible working

Birthday day off

Lunch & food

Learning & development

Zusammenfassung

Ridgeline Discovery is seeking several highly motivated researchers (Sr) to support a portfolio company emerging from stealth mode. Experience in high-throughput screening and MS-based drug discovery, especially targeting degradation, is desired.

You will work in a dynamic start-up setting with an interdisciplinary team to advance early and late-stage projects. The role emphasizes rigorous data analysis, collaboration, and strong communication in English.

Qualifikationen

• Hold a Master/Bachelor or apprenticeship in Biotechnology, Biochemistry, or Molecular Biology with 2+ years in proteomics.
• PhD holders with 2+ years MS experience in drug discovery are preferred.
• Strong experimental design and data-sharing skills.
• Experience with UHPLC and high-end MS instruments is advantageous.

Aufgaben

• Collaborate with biologists to prep samples for MS-based screening and run high-resolution mass spectrometry.
• Develop and optimize sample prep and automation; monitor MS performance.
• Oversee large-scale proteomics data generation and analysis.
• Identify potential novel drug targets with an interdisciplinary team.
• Stay current with literature and contribute to company goals.

Kenntnisse

Proteomics

Mass spectrometry

Data analysis

English

Experimental design

Ausbildung

Master/Bachelor in Biotechnology/ Biochemistry/ Molecular Biology

PhD in Biochemistry/ Biology/ Chemical Biology

Tools

UHPLC systems

Orbitrap Astral

timsTOF

S-trap

SP3

PAC

Tecan

Biomek

Hamilton

Agilent Bravo

OT-2

DIA-NN

Spectronaut

R

Python

Jobbeschreibung

We are looking for several highly motivated (Sr) Research Associates/ (Senior) Scientists responsible to support one of Ridgeline Discovery’s portfolio company about to come out of stealth mode.

The successful candidate will have experience in High throughput screening and/or Mass Spectrometry-Based Drug Discovery ideally applied to targeted protein degradation (job title will be based on previous experience). She/he will be a highly motivated and enthusiastic team player with proven organizational skills, and a strong scientific background to impact early and late-stage development projects.

Responsibilities

• Collaborate with cell biologists to prepare samples for MS-based screening, operate state-of-the-art high resolution mass spectrometers, analyze and interpret multi-layered data, and present findings to stakeholders and external collaborators.
• Develop and implement sample preparation and automation protocols, optimize mass spectrometer performance, and adapt novel technologies.
• Oversee data generation and analysis of large-scale proteomics datasets.
• Work closely with an interdisciplinary team to identify potential novel drug targets.
• Stay engaged with scientific literature to remain up-to-date with the latest developments and novel approaches.
• Be proactive and open-minded in contributing to the achievement of the company’s goals in a dynamic and fast-paced start-up environment.
• Characterize novel drug targets and their mechanisms of action.
• Contribute to laboratory general organization and maintenance, manage laboratory stocks and ordering.
• Ensure compliance with good laboratory practices including safety regulations, data management, data recording in electronic notebooks and archiving.

Qualifications

• Research associate level: you hold a Master, Bachelor degree or laboratory apprenticeship (or equivalent) in Biotechnology, Biochemistry, Molecular Biology, with at least 2 years of experience in academia, contract research, or the biotechnology/pharmaceutical industry, particularly in the field of proteomics.
• Scientist level: you hold a PhD in Biochemistry, Biology, Chemical Biology or other relevant disciplines and preferentially 2+ years’ relevant MS experience in drug discovery in the pharmaceutical, biotech or MS contract research setting.
• You are skilled in designing, planning, and executing laboratory experiments and are passionate about analyzing data and sharing your findings.
• Experience with the latest generation UHPLC systems and mass spectrometers (such as Orbitrap Astral or timsTOF) for in-depth proteome characterization and/or targeted analysis is a plus.
• Experience in high-throughput peptide/protein sample preparation (S-trap/SP3/PAC), automation (Tecan/Biomek/Hamilton/Agilent Bravo/OT-2) and DIA (data-independent acquisition) data analysis is desired.
• Knowledge of Spectronaut or DIA-NN and bioinformatics tools, such as R or Python, is a plus.
• You are an organized team player, adept at critical thinking and problem solving, with excellent communication skills in English.
• Must be highly independent, able to work well in a highly collaborative team-oriented environment. Capable of thriving and multi-tasking in a fast-paced “start-up” environment.
• Self-motivated, willingness to learn, strong work ethic, attention to detail, organizational skills, and excellent communication skills are required for this position.
• Fluency in English required

Closing date: 30th of September

What we currently offer

• Prime Location: Our state-of-the-art laboratories and modern offices are located at the Technologiepark Basel, one of the city’s leading hubs for innovative and ambitious life-science start-ups.
• Commuter Benefits: We support your individual commuting needs with flexible options, including parking facilities or a commuter contribution.
• Flexible Working: We believe in flexibility and support modern ways of working wherever the role and business needs allow.
• Christmas Closure: Enjoy a well-deserved break at the end of the year. In addition to 24 days of annual leave, our offices and laboratories are closed between Christmas and New Year.
• Birthday Day Off: Your birthday is your day. Celebrate it your way with an extra paid day off to enjoy the things that matter to you.
• Lunch & Food: Great ideas often start around the lunch table. Enjoy delicious meals with your colleagues, supported through our Lunch Check benefit.
• Coffee & Connection: Take a break, grab a complimentary coffee, and connect with colleagues throughout the day.
• Learning & Development: We invest in our people and support individual growth, learning and professional development.
• Innovation & Creativity: Be part of an innovative, entrepreneurial and creative environment where new ideas are encouraged and collaboration is at the heart of what we do.
• Our People: Join an international and diverse team of talented, curious and passionate people who are united by the ambition to make a difference in science and healthcare.

Please note that the benefits and working conditions described above are subject to change and may be amended by the Company from time to time, depending on business needs, applicable policies and management decisions.