(Senior) Research Associate/(Senior) Scientist, High throughput Proteomics in Targeted Protein Degradation

Serac Biosciences; Basel; On-site; CHF 90,000 - 130,000; Full time

Benefits offered by this job

Prime Location Basel

Commuter benefits

Flexible working

Birthday day off

Lunch & Food

Coffee & connection

Learning & development

Innovation & creativity

Our people

Job summary

Ridgeline Discovery is seeking multiple (Sr) Research Associates / (Senior) Scientists to advance MS-based drug discovery in proteomics. You will collaborate with cell biologists, operate high-resolution MS and UHPLC systems, and drive data analysis for target discovery and validation.

You will contribute to protocol development, automation, and interdisciplinary collaboration in a fast-paced startup environment, with a strong emphasis on data integrity and team teamwork.

Qualifications

• Academic or industry proteomics experience with MS-based discovery.
• Experience with high-throughput sample prep and automation.
• Strong data analysis and interpretation skills.
• Excellent English communication and collaboration in teams.
• Ability to thrive in a dynamic startup environment.

Responsibilities

• Collaborate with biologists to prepare samples for MS screening and analyze data.
• Develop and optimize sample prep and automation protocols.
• Oversee large-scale proteomics data generation and analysis.
• Work with interdisciplinary teams to identify novel drug targets.
• Stay current with literature and new approaches for proteomics.

Skills

Proteomics

Mass spectrometry

Automation

Data analysis

English communication

Team collaboration

Critical thinking

Education

Master/Bachelor in biotech

PhD in Biochemistry/ Biology

Tools

Orbitrap Astral

DIA-NN / Spectronaut

Tecan/Biomek/Hamilton/OT-2

R / Python

S-trap / SP3

UHPLC systems

Job description

About us

We are looking for several highly motivated (Sr) Research Associates/ (Senior) Scientists responsible to support one of Ridgeline Discovery's portfolio company about to come out of stealth mode.

The successful candidate will have experience in High throughput screening and/or Mass Spectrometry-Based Drug Discovery ideally applied to targeted protein degradation (job title will be based on previous experience). She/he will be a highly motivated and enthusiastic team player with proven organizational skills, and a strong scientific background to impact early and late-stage development projects.

Responsibilities

• Collaborate with cell biologists to prepare samples for MS-based screening, operate state-of-the-art high resolution mass spectrometers, analyze and interpret multi-layered data, and present findings to stakeholders and external collaborators.
• Develop and implement sample preparation and automation protocols, optimize mass spectrometer performance, and adapt novel technologies.
• Oversee data generation and analysis of large-scale proteomics datasets.
• Work closely with an interdisciplinary team to identify potential novel drug targets.
• Stay engaged with scientific literature to remain up-to-date with the latest developments and novel approaches.
• Be proactive and open-minded in contributing to the achievement of the company's goals in a dynamic and fast-paced start-up environment.
• Characterize novel drug targets and their mechanisms of action.
• Contribute to laboratory general organization and maintenance, manage laboratory stocks and ordering.
• Ensure compliance with good laboratory practices including safety regulations, data management, data recording in electronic notebooks and archiving.

Qualifications

• Research associate level: you hold a Master, Bachelor degree or laboratory apprenticeship (or equivalent) in Biotechnology, Biochemistry, Molecular Biology, with at least 2 years of experience in academia, contract research, or the biotechnology/pharmaceutical industry, particularly in the field of proteomics.
• Scientist level: you hold a PhD in Biochemistry, Biology, Chemical Biology or other relevant disciplines and preferentially 2+ years' relevant MS experience in drug discovery in the pharmaceutical, biotech or MS contract research setting.
• You are skilled in designing, planning, and executing laboratory experiments and are passionate about analyzing data and sharing your findings.
• Experience with the latest generation UHPLC systems and mass spectrometers (such as Orbitrap Astral or timsTOF) for in-depth proteome characterization and/or targeted analysis is a plus.
• Experience in high-throughput peptide/protein sample preparation (S-trap/SP3/PAC), automation (Tecan/Biomek/Hamilton/Agilent Bravo/OT-2) and DIA (data-independent acquisition) data analysis is desired.
• Knowledge of Spectronaut or DIA-NN and bioinformatics tools, such as R or Python, is a plus.
• You are an organized team player, adept at critical thinking and problem solving, with excellent communication skills in English.
• Must be highly independent, able to work well in a highly collaborative team-oriented environment. Capable of thriving and multi-tasking in a fast-paced start-up environment.
• Self-motivated, willingness to learn, strong work ethic, attention to detail, organizational skills, and excellent communication skills are required for this position.
• Fluency in English required

What we currently offer

• Prime Location: Our state-of-the-art laboratories and modern offices are located at the Technologiepark Basel, one of the city’s leading hubs for innovative and ambitious life-science start-ups.
• Commuter Benefits: We support your individual commuting needs with flexible options, including parking facilities or a commuter contribution.
• Flexible Working: We believe in flexibility and support modern ways of working wherever the role and business needs allow.
• Christmas Closure: Enjoy a well-deserved break at the end of the year. In addition to 24 days of annual leave, our offices and laboratories are closed between Christmas and New Year.
• Birthday Day Off: Your birthday is your day. Celebrate it your way with an extra paid day off to enjoy the things that matter to you.
• Lunch & Food: Great ideas often start around the lunch table. Enjoy delicious meals with your colleagues, supported through our Lunch Check benefit.
• Coffee & Connection: Take a break, grab a complimentary coffee, and connect with colleagues throughout the day.
• Learning & Development: We invest in our people and support individual growth, learning and professional development.
• Innovation & Creativity: Be part of an innovative, entrepreneurial and creative environment where new ideas are encouraged and collaboration is at the heart of what we do.
• Our People: Join an international and diverse team of talented, curious and passionate people who are united by the ambition to make a difference in science and healthcare.

Please note that the benefits and working conditions described above are subject to change and may be amended by the Company from time to time, depending on business needs, applicable policies and management decisions.