Senior Expert Science & Technology (Oligonucleotide Chemist)

Healthcare Businesswomen’s Association; Basel; Vor Ort; CHF 30’000 - 80’000; Vollzeit

Zusammenfassung

A healthcare organization in Basel is seeking an experienced Oligonucleotide Chemist to define synthesis strategies and develop efficient processes for drug manufacturing. The ideal candidate holds a PhD in Organic Chemistry or Chemical Engineering and has a strong background in oligonucleotide processes. Key responsibilities include collaborating with internal stakeholders and optimizing lab resources. The organization is committed to building an inclusive work environment and provides accommodations for those in need.

Qualifikationen

• Completed PhD in Organic Chemistry or Chemical Engineering.
• PostDoc focusing on oligonucleotides processes.
• Experience in downstream processing including TFF and chromatographic processes.

Aufgaben

• Define fit-for-purpose synthesis strategy for drug substance manufacturing.
• Develop efficient and scalable oligonucleotide processes.
• Co-lead the process transfer to pilot plants.

Kenntnisse

Experience in developing platform synthesis concepts for oligonucleotides

Fluency in English

Experience in process development using state of art oligo synthesizers

Excellent track record of original research

Ausbildung

PhD in Organic Chemistry or Chemical Engineering

PostDoc with a focus on oligonucleotides processes

Jobbeschreibung

Job Description Summary

Location: Basel, Switzerland #onsite

Job Description

We have a fantastic opportunity for a Oligonucleotide Chemist in our CHAD department here in Basel.

Your responsibilities

• Defining fit-for-purpose synthesis strategy for drug substance manufacturing and Health Authority documentation.
• Develop efficient and scalable oligonucleotide processes on relevant projects within Novartis portfolio across different scales.
• Be part of the Oligo chemist / engineering team to develop and optimize syntheses used in process R&D.
• Investigate various approaches for oligonucleotide preparation and evaluate their potential by applying cutting‑edge automated platforms.
• Ensuring utilization of state-of-the-art technologies and science.
• Efficient use of lab resources.
• Maintaining oversight on process safety.
• Co‑leading the process transfer to pilot plants.
• Serving as consultants for troubleshooting during campaigns.
• Collaborating with internal and external stakeholders or partners.
• Collaborate with diverse experts in the areas of Nucleic Acid Chemistry, Process Chemistry, Process Engineering and Analytics.

What you’ll bring to the role

• A completed PhD in Organic Chemistry, or Chemical engineering.
• PostDoc with a focus on oligonucleotides processes.
• Experience in developing platform synthesis concepts for oligonucleotides.
• Experience in process development using state of art oligo synthesizers.
• Experience in downstream processing including TFF and chromatographic processes.
• An excellent track record of original research and extensive experience in using “state of the art” technologies.
• Fluency in English.

Commitment to Diversity and Inclusion

Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.

Accessibility and accommodation

Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to [e-mail] and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Skills Desired