Principal DMPK Scientist, Preclinical Biology & Pharmacology

GXPeople Global Ltd.; Bern; On-site; CHF 170,000 - 260,000; Full time

Benefits offered by this job

Relocation support

Job summary

GXPeople Global Ltd. seeks a Principal Scientist, Preclinical Biology & Pharmacology (DMPK) to design and execute DMPK strategies for novel compounds in a global environment. The role requires hands-on preclinical DMPK experience and the ability to lead execution through internal teams or CROs.

You will integrate in vitro, ex vivo and in vivo data to guide development decisions, while guiding multidisciplinary DMPK/ADME programmes and scientific strategy.

Qualifications

• PhD in Pharmacology or Biological Sciences required.
• Demonstrated leadership and strategic capability in DMPK/ADME projects.
• Strong communication and collaboration across disciplines.

Responsibilities

• Develop and lead DMPK strategies for novel compounds.
• Integrate in vitro, ex vivo and in vivo data to guide programme progression.
• Lead multidisciplinary project teams and provide scientific direction.
• Translate complex science into actionable recommendations for leadership.
• Collaborate with PM, Clinical, Computational Biology and CRO partners.

Skills

Engagement

Influencing

Communication

Strategic thinking

Analytical skills

Education

PhD in Pharmacology or Biological Sciences

Job description

Principal Scientist, Preclinical Biology & Pharmacology - DMPK

Location: Switzerland | Relocation support available

We are supporting a global R&D innovative FMCG organisation in the appointment of a Principal Scientist, Preclinical Biology & Pharmacology to perform experimental pre-clinical DMPK.

You should have previous hands-on laboratory pre-clinical DMPK experience, you can independently design DMPK studies, lead their execution internally or through CROs, interpret the results and use them to make compound-development decisions.

This is a senior individual-contributor position for an experienced scientist who has progressed from hands-on research into leading multidisciplinary DMPK/ADME programmes and guiding the scientific strategy required to progress novel compounds.

The role

You will develop the DMPK/ADME strategy and lead its implementation and execution across novel-compound programmes.

The research may involve in vitro, ex vivo and in vivo approaches, with the Principal Scientist responsible for bringing together evidence from different scientific disciplines to guide programme decisions.

You do not need to personally perform every type of study. You should, however, understand how the different evidence streams fit together and be able to provide scientific direction to specialists contributing to the programme.

You will:

• Develop and lead DMPK strategies for novel compounds.
• Lead the implementation and execution of DMPK programmes from a scientific and operational perspective.
• Determine the studies and evidence required to support programme progression.
• Lead multidisciplinary project teams without direct line-management responsibility.
• Use PK, DMPK, ADME information to inform development decisions.
• Critically evaluate scientific data, study designs and proposed development strategies.
• Work closely with Project Management, Clinical, Computational Biology and other scientific specialists within a matrix R&D environment.
• Provide scientific guidance while drawing on expertise from specialists across different disciplines.
• Translate complex science into clear recommendations for senior stakeholders.
• Present scientific programmes, strategies and recommendations to senior leadership and governance groups.
• Work with internal scientists and external research partners where appropriate.

What we're looking for

• PhD in Pharmacology or Biological Sciences
• Minimum of 5 years of experience post-PhD in Drug Metabolism and Pharmacokinetics with demonstrated experience of advancing research programs to key internal decision points and evidence-based innovations/product outcomes.
• Demonstrated expertise in health areas such as neuroscience, pulmonary health, cardiovascular health, oral health.
• Strong business acumen gained through industry leadership experience involving scientific and operational leadership
• Sound scientific and operational leadership, critical thinking, strategic mindset, result-focus and analytical skills/problem-solving/data driven decision-making skills.
• Creativity / innovation mindset.
• Strong engagement, influencing and communication skills.
• Fluency in both written and spoken English.
• Holding an EU/EFTA/Switzerland passport or having a valid legal right to work in Switzerland, and being able to relocate.

Particularly valuable experience

Experience applying pharmacology across more than one relevant health territory would be particularly valuable, especially across neuroscience, cardiovascular/cardiometabolic, pulmonary/respiratory or oral health.

We are interested in scientists who have worked with small molecules and/or other relevant bioactive compounds. The role is not primarily focused on monoclonal antibodies, gene therapies or other advanced therapeutic modalities.

What's in it for you?

Join a large, well-funded global organisation with a strong focus on science, innovation and future product development.

You will have the opportunity to lead scientifically complex programmes, work across multiple health territories and scientific disciplines, and influence important development decisions while remaining closely connected to the science.

The position offers a competitive salary and benefits package, along with relocation support to Switzerland.

If you’re an experienced DMPK scientist who enjoys bringing together different areas of science to guide novel compounds through development, we’d love to hear from you.

Before applying:

Please review the must-have requirements carefully and answer the screening questions accurately. These reflect specific criteria agreed with the hiring team and will be verified against your experience before progression.