Postdoc - Targeting Allergic Hypersensitivity - Wymann Lab UniBas

University of Basel; Schweiz; Vor Ort; CHF 70.000 - 90.000; Vollzeit

Zusammenfassung

The Department of Biomedicine at the University of Basel invites qualified candidates for a post-doctoral position to investigate allergic, immunologic and metabolic processes. The role involves multi-disciplinary work, including signaling pathways in inflammation and cancer, and collaboration with chemists on bioactive molecules.

Applicants should hold a PhD in relevant life-science fields, with strong immunology/FACS experience, a proven publication record, and the ability to work in Basel,

Qualifikationen

• PhD in Biochemistry, Molecular Biology, Immunology or related life-science field.
• Experience in Immunology, allergy, FACS (analysis and cell sorting) and mouse models.
• Strong publication record in peer-reviewed journals and/or patents.

Aufgaben

• Elucidate signal transduction involving GPCR and cytokine pathways in inflammatory and metabolic networks.
• Perform functional immune cell assays and biomarker detection in vitro and in vivo.
• Assess immune cell responses via FACS, high content imaging, proteomics and transcriptomics.
• Identify targetable signaling nodes within the studied pathways.
• Set up in vitro and in vivo validation workflows for novel small molecules.
• Publish findings and contribute to patents and regulatory reports.
• Mentor students and collaborate with team members for career development.

Kenntnisse

Immunology

Allergy

FACS

Mouse models

Ausbildung

PhD in Biochemistry, Molecular Biology, Immunology or related Life-Science field

Tools

FACS

Mouse models

Jobbeschreibung

Organisation/Company University of Basel Department Department of Biomedicine Research Field Biological sciences » Biology Medical sciences » Health sciences Researcher Profile Recognised Researcher (R2) Positions Postdoc Positions Application Deadline 1 Oct 2026 - 17:00 (Europe/Zurich) Country Switzerland Type of Contract Temporary Job Status Full-time Hours Per Week 42.5 Offer Starting Date 1 Sep 2026 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Reference Number CTI7_Wymann Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Starting immediately or as negotiated

The Department of Biomedicine (DBM) integrates basic and clinical researchers from University of Basel and University Hospitals committed to deepen the understanding of health and disease while driving the development of innovative therapies that address unmet medical needs.With over 70 research groups and 800 employees, the Department of Biomedicine is the largest department within the University of Basel. Be part of our future!

The Wymann lab at the DBM Mattenstrasse, University of Basel, Switzerland, invites qualified candidates to apply for a post-doctoral position in Biomedical Research investigating allergic, immunologic and metabolic processes. The candidate will join a multi-disciplinary team focusing on the elucidation and targeting of major stress and lipid kinase signaling pathways in allergic hypersensitivity, allergy, chronic inflammation and cancer. Besides performing biochemical, cellular and mouse genetic studies, the candidate interacts with Chemists developing novel bioactive small molecules targeting relevant signaling nodes in the mentioned pathologies.

The working place of the successful candidate is the Department of Biomedicine at Mattenstrasse 28, 4057 Basel.

Project:

The aim of the project is to elucidate molecular intra- and extracellular mechanisms of signaling modulating myeloid cells’ immune responses. The project is supported by Innosuisse and has a translational goal aiming to pave a path to clinical applications. This project is flanked by basic research projectsi) investigating of the role of phosphoinositide 3-kinase (PI3K) signaling in allergy, metabolic control, obesity, diabetes and cancer; see https://p3.snf.ch/project-189065 ii) developing and validation of novel chemical probes and degraders to dissect mechanisms of adverse effects in cancer and metabolism. For a summary of the latter see: https://p3.snf.ch/project-204602

Your assignments

• Elucidating signal transduction involving GPCR, cytokine-, immunoglobulin downstream signaling involved in an inflammatory and metabolic network.
• Functional immune cell / phenotypic / response output assays and biomarker detection /identificationin vitro and in vivo.
• Determining immune cell responses via FACS, high content imaging microscopy, proteomics and transcriptomics and more.
• Identification of targetable signaling nodes in the above pathways.
• Set-up of in vitro and in vivo validation workflows for novel small molecules.
• Writing of scientific publications, patents and regulatory reports.
• Personal career and leadership development, mentoring of students and collaborators.

The successful candidate holds a PhD in Biochemistry, Molecular Biology, Immunology or another relevant Life-Science degree. Expertise in immunology, allergy, FACS (analysis and cell sorting), and mouse models is required. The candidate should hold a LTK module 1 (rodent course, Switzerland) or a FELASA function A/C/D (EU) certificate, including the required associated continued formation.

The candidate has an excellent proven track record in the publication of peer-reviewed scientific articles and/or patents.

Languages

ENGLISH Level Excellent

Research Field Biological sciences » Laboratory animal sciencePharmacological sciences » Other Years of Research Experience 1 - 4

Additional Information

University of Basel is an equal opportunity employer. Salaries are according to the staff-regulations and depend on the qualifications and experience of the candidate.

The position will be initially for one year.

Eligibility criteria

Ph.D. in Biochemistry, Biology or related sciences, excellent research background. Experience in Immunology, FACS, FELASA animal experimentation preferred.

Selection process

As soon as suitable candidates are identified, the final recruitment is started.